A5103265892- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Autophagy in Disease and Therapy
- Anesthesia and Pain Management
- RNA Interference and Gene Delivery
- Pain Mechanisms and Treatments
- Pediatric Pain Management Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacological Effects of Natural Compounds
- Respiratory Support and Mechanisms
- Nanoplatforms for cancer theranostics
- Adenosine and Purinergic Signaling
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Epilepsy research and treatment
- Mechanical Circulatory Support Devices
- Cancer, Stress, Anesthesia, and Immune Response
- Myasthenia Gravis and Thymoma
- Eicosanoids and Hypertension Pharmacology
- interferon and immune responses
- Innovation Policy and R&D
- Pluripotent Stem Cells Research
- Ion channel regulation and function
- CRISPR and Genetic Engineering
Union Hospital
2019-2025
Huazhong University of Science and Technology
2019-2025
Nanjing University of Posts and Telecommunications
2023-2024
Zhujiang Hospital
2024
Southern Medical University
2024
Union Hospital
2020-2024
The Synergetic Innovation Center for Advanced Materials
2024
Shanghai Institutes for Biological Sciences
2014-2022
Chinese Academy of Sciences
2014-2022
Zhejiang Sci-Tech University
2022
Fault diagnosis of bearings using classification techniques plays an important role in industrial applications, and, hence, has received increasing attention. Recently, significant efforts have been made to develop various methods for bearing fault and the application Case Western Reserve University (CWRU) data validation become a standard reference test algorithms. However, systematic research evaluating performance CWRU is still lacking. This paper aims provide comprehensive benchmark...
Autophagy is an evolutionarily conserved biological process involved in array of physiological and pathological events. Without proper control, autophagy contributes to various disorders, including cancer autoimmune inflammatory diseases. It therefore vital importance that under careful balance. Thus, additional regulators undoubtedly deepen our understanding the working network, provide potential therapeutic targets for disorders. In this study, we found RNF216 (ring finger protein 216), E3...
Inducing immunogenic cell death (ICD) during photothermal therapy (PTT) has the potential to effectively trigger immunotherapy (PTI). However, ICD induced by PTT alone is often limited inefficient PTT, low immunogenicity of tumor cells, and a dysregulated redox microenvironment. Herein, we develop MoSe2 nanosheets with high-percentage metallic 1T phase rich exposed active Mo centers through defect engineering as an effective nanoagent for PTI. The in endows them strong performance, abundant...
Abstract Radiation-induced in situ tumor vaccination alone is very weak and insufficient to elicit robust antitumor immune responses. In this work, we address issue by developing chiral vidarabine monophosphate-gadolinium nanowires (aAGd-NWs) through coordination-driven self-assembly. We elucidate the mechanism of aAGd-NW assembly characterize their distinct features, which include a negative surface charge, ultrafine topography, right-handed chirality. Additionally, aAGd-NWs not only...
Radiation therapy (RT) has the capacity to induce immunogenic death in tumor cells, thereby potentially inducing situ vaccination (ISV) prime systemic antitumor immune responses. However, RT alone is often faced with various limitations during ISV induction, such as insufficient X-ray deposition and an immunosuppressive microenvironment. To overcome these limitations, we constructed nanoscale coordination particles AmGd-NPs by self-assembling high-Z metal gadolinium (Gd) small molecular CD73...
Background: Early recognition of the risk acute respiratory distress syndrome (ARDS) after cardiopulmonary bypass (CPB) may improve clinical outcomes. The main objective this study was to identify proteomic biomarkers and develop an early prediction model for CPB-ARDS. Methods: authors conducted three prospective nested cohort studies all consecutive patients undergoing cardiac surgery with CPB at Union Hospital Tongji Medical College Hospital. Plasma profiling performed in ARDS matched...
Hepatitis B virus (HBV) infection brings a huge challenge for medical health practitioners. It has been reported that invaded HBV escapes autophagic degradation through inhibiting lysosome maturation following enhanced autophagy formation, which putatively contributes to replication and infection. However, the underlying mechanism by from remains elusive. In this study, we monitored process using HepG2 cells mice without or with transient DNA plasmid transfection (pHepG2) stable (HepG2.2.15...
The disturbance of the immune homeostasis caused by infection is decisive for multiple organ dysfunction sepsis. Both th17 cell and regulatory cell(Tregs) are important components system play a crucial role in maintaining homeostasis. In this study, we explored effect Maresin1, an emerging specific pro-inflammatory mediator, on balance Th17/Treg sepsis, investigated underlying mechanism. We used male C57BL/6 mice to establish model sepsis-induced lung injury cecal ligation puncture verify...
The irradiated tumor itself represents an opportunity to establish endogenous in situ vaccines. However, such cancer vaccination (ISCV) triggered by radiation therapy (RT) alone is very weak and hardly elicits systemic anticancer immunity. In this study, we develop two-dimensional risedronate-manganese nanobelts (RMn-NBs) as adjuvant for RT address issue. RMn-NBs exhibit good T
// Hui Wang 1, * , Yanan Liu Qian Xue 1 Hailiang Gu 2 Xiaoqiang Dong Shiqian Huang Min Jin Ge Congfeng Xu Yanyun Zhang Shanghai Institute of Immunology, Institutes Medical Sciences, Jiao Tong University School Medicine (SJTUSM) and Key Laboratory Stem Cell Biology, Health for Biological Chinese Academy Sciences & SJTUSM, Shanghai, China Department General Surgery, The First Affiliated Hospital Soochow University, Suzhou, These authors have contributed equally to this work Correspondence...
Abstract Pain is a common symptom of many diseases with high incidence rate. Clinically, drug treatment, as the main method to relieve pain at present, often accompanied by different degrees adverse reactions. Therefore, it urgent gain profound understanding mechanisms in order develop advantageous analgesic targets. The PD-L1/PD-1 pathway, an important inhibitory molecule immune system, has taken part regulating neuroinflammation and response. Accumulating evidence indicates that pathway...
Nicotinic ACh receptors containing the α7 sub-unit (α7-nAChRs) suppress inflammation through a wide range of pathways in immune cells. These are thus potentially involved number inflammatory diseases. However, detailed mechanisms underlying anti-inflammatory effects α7-nAChRs remain to be described.Anti-inflammatory α7-nAChR agonists were assessed both murine macrophages (RAW 264.7) and bone marrow-derived (BMDM), stimulated with LPS, using immunoblotting, RT-PCR luciferase reporter assays....
The mortality risk related to anaesthesia in China remains poorly characterized. objective of this study was evaluate the anaesthesia-related terms its incidence, changes, causes and preventability Hubei, China, between 2017 2021 using a series annual surveys.We prospectively collected information on patient, surgical, anaesthesia, hospital characteristics for 9,391,669 procedures performed 10 cities within Hubei Province, China. Anaesthesia-related death defined as that deemed be entirely...