A5100617892- Anesthesia and Neurotoxicity Research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Anesthesia and Sedative Agents
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Intensive Care Unit Cognitive Disorders
- Neonatal and fetal brain pathology
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Automotive and Human Injury Biomechanics
- Health disparities and outcomes
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Iron Metabolism and Disorders
- Circular RNAs in diseases
- Anesthesia and Pain Management
- Neurogenesis and neuroplasticity mechanisms
- Heavy Metal Exposure and Toxicity
- Inflammatory mediators and NSAID effects
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- Cardiovascular Function and Risk Factors
- Folate and B Vitamins Research
Texas Tech University
2025
Zhengzhou Children's Hospital
2018-2025
Zhengzhou University
2015-2025
Union Hospital
2021-2025
Huazhong University of Science and Technology
2021-2025
Union Hospital
2024-2025
Qinghai Provincial Peoples Hospital
2019-2024
Jiangnan University
2022-2024
Weatherford College
2024
North China University of Science and Technology
2023-2024
Abstract Blood biomarkers provide critical information about the health of older populations, especially in large developing countries where self-reports are often inaccurate due to lack access care. However, it is very difficult collect blood samples representative population surveys such countries. The China Health and Retirement Longitudinal Study (CHARLS), a nationally study middle-aged Chinese, represents one first efforts include survey China. In 2015 wave CHARLS, 13,013 respondents...
Abstract Background Perioperative neurocognitive disorders (PND) with a high incidence frequently occur in elderly surgical patients closely associated prolonged anesthesia-induced neurotoxicity. The neuromorphopathological underpinnings of neurotoxicity have remained elusive. Methods Prolonged anesthesia sevoflurane was used to establish the sevoflurane-induced (SIN) animal model. Morris water maze, elevated plus and open field test were employed track SIN rats’ cognitive behavior...
Evidence highlights the importance of muscular strength as a protective factor for health and function across aging populations. The purpose this study was to examine extent which low normalized grip (NGS) serves biomarker both cardiometabolic disease physical disability in U.S. Chinese adults. Middle aged older adults from National Health Nutrition Examination Survey 2011–2012 2013–2014 combined surveys (n = 4,544), 2011 wave China Retirement Longitudinal Study 6,030) were included....
To compare and validate neurocognitive tests in the Harmonized Cognitive Assessment Protocol (HCAP) for China Health Retirement Longitudinal Study (CHARLS), to identify appropriate be administered future waves of CHARLS.We recruited 825 individuals from CHARLS sample 766 subjects hospitals six provinces cities China. All participants were HCAP-neurocognitive tests, their informants interviewed regarding respondents' functional status. Trained clinicians Clinical Dementia Rating scale (CDR)...
For the strapdown inertial navigation system (SINS) on vertically launched and warship-borne missiles, transfer alignment is an effective approach to estimate its attitudes at time of launching which also called initial SINS. The quaternions are adopted describe attitudes, a model with this description established. However, due strong nonlinearity model, non-Gaussian distributions gyros drifts, demands for speed precision, it poses great challenge estimation In order solve problem, new...
Abstract Background Radiation‐induced brain injury is a neurological condition resulting from radiotherapy for malignant tumors, with its underlying pathogenesis still not fully understood. Current hypotheses suggest that immune cells, particularly the excessive activation of microglia in central nervous system and migration peripheral cells into brain, play critical role initiating progressing injury. This review aimed to summarize latest advances cellular molecular mechanisms therapeutic...
The safety of small drones in collision with humans has become a key focus engineering and research fields. This study presents vertical drop test platform for tests involving three representative (Air, Mavic 2, M200) impacting the head Hybrid III dummy from different heights orientations. deformation damage during various scenarios, as well dynamic responses neck, are analyzed. injury criterion (HIC), together 3 ms cumulative acceleration (head acc ms), used to evaluate injury, while shear...
Abstract Radiotherapy is an effective tool in the treatment of malignant brain tumors. However, damage to stem and progenitor cells constitutes a major problem associated with long-term side effects. Autophagy has been shown be involved cell death, purpose this study was evaluate effect autophagy inhibition on neural death juvenile brain. Ten-day-old selective Atg7 knockout (KO) mice wild-type (WT) littermates were subjected single 6Gy dose whole-brain irradiation. Cell proliferation as well...
Abstract Apoptosis inducing factor (AIF) has been shown to be a major contributor neuron loss in the immature brain after hypoxia-ischemia (HI). Indeed, mice bearing hypomorphic mutation causing reduced AIF expression are protected against neonatal HI. To further investigate possible molecular mechanisms of this neuroprotection, we generated an knock-in mouse by introduction latent transgene coding for flagged protein into Rosa26 locus, followed its conditional activation ubiquitously...
Abstract Background Diabetes-related limb ischemia is a challenge for lower extremity amputation. Aurora Kinase A (AURKA) an essential serine/threonine kinase mitosis, while its role in remains unclear. Method Human microvascular endothelial cells (HMEC-1) were cultured high glucose (HG, 25 mmol/L d -glucose) and no additional growth factors (ND) medium to mimic diabetes low deprivation as vitro model. Diabetic C57BL/6 mice induced by streptozotocin (STZ) administration. After seven days,...