A5076066320- Multiple Myeloma Research and Treatments
- Air Quality and Health Impacts
- Cancer Immunotherapy and Biomarkers
- Climate Change and Health Impacts
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Nonmelanoma Skin Cancer Studies
- Hedgehog Signaling Pathway Studies
- Chronic Lymphocytic Leukemia Research
- Ovarian function and disorders
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Energy and Environment Impacts
- Chronic Myeloid Leukemia Treatments
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Ovarian cancer diagnosis and treatment
- Air Quality Monitoring and Forecasting
- Tumors and Oncological Cases
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Synthesis and Biological Evaluation
- Eosinophilic Esophagitis
- Health, Environment, Cognitive Aging
- Ferroptosis and cancer prognosis
Regeneron (United States)
2018-2024
New York University
2013-2021
Indiana University School of Medicine
2021
Fudan University
2011
Metabolomics may unravel global metabolic changes in response to environmental exposures and identify important biological pathways involved the pathophysiology of childhood obesity. Phthalate has been considered an obesogen contributing overweight obesity children. The purpose this study is evaluate urine metabolites phthalate exposure among or obese children, investigate mechanisms obesogenic effect on children at puberty. Within national Puberty Timing Health Effects Chinese Children...
Diffuse large B-cell lymphoma (DLBCL) and follicular (FL) treatments have been rapidly evolving for patients treated in later lines of therapy (LoT). Country-specific cancer registry data the US Western Europe (WE) were combined with physician survey results to project incidence, prevalence, number DLBCL FL eligible by LoT between 2020 2025. The total incidents prevalent cases is expected increase 2025 WE. 56% 53% third line plus (3L+) 60% 55% initiated treatment WE, respectively. Further...
Lipodystrophies are a group of disorders characterized by absence or loss adipose tissue and abnormal fat distribution, commonly accompanied metabolic dysregulation. Although considered rare disorders, their prevalence in the general population is not well understood. We aimed to evaluate clinical genetic lipodystrophy large care cohort. interrogated electronic health record (EHR) information >1.3 million adults from Geisinger Health System for diagnostic codes. estimate disease 1 20,000...
Metabolomics is a novel tool to explore the biological mechanisms of health effects fine particulate matter (PM2.5) air pollution. Very few studies have examined urinary metabolomic changes associated with PM2.5 exposure.To assess alternation in urine metabolomics response short-term exposure.We conducted randomized, double-blind, crossover trial 9-day real or sham indoor purification among 45 healthy college students Shanghai, China. Urine samples were collected immediately at end each...
This study was designed to examine the impact of prenatal fine particulate matter (PM2.5) exposure on fetal growth and underlying placental epigenetic mechanism in a cohort Chinese women. Within prospective Shanghai Mother-Child Pairs (Shanghai MCPC), 329 women carrying singleton pregnancy with due date 2018 were recruited between 2017 2018. Maternal PM2.5 levels estimated using gestational prediction model combining satellite-driven ambient concentrations personal air sampling. Fetal...
A strong positive association has been observed between circulating anti-Müllerian hormone (AMH), a biomarker of ovarian reserve, and breast cancer risk in three prospective studies. Confirming this is important because the paucity biomarkers premenopausal women. We conducted consortium study including ten cohorts that had collected blood from nested case-control design was implemented within each cohort. total 2,835 invasive (80%) situ (20%) cases were individually matched to controls (n =...
Models that accurately predict risk of breast cancer are needed to help younger women make decisions about when begin screening. Premenopausal concentrations circulating anti-Müllerian hormone (AMH), a biomarker ovarian reserve, and testosterone have been positively associated with in prospective studies. We assessed whether adding AMH and/or the Gail model improves its prediction performance for aged 35–50. In nested case-control study including ten cohorts (1762 invasive cases/1890 matched...
Polybrominated diphenyl ethers (PBDEs) are environmental chemicals with harmful effects on pregnancy, but their adverse developmental outcomes not fully understood. The placental DNA methylation is strongly influenced by prenatal factors and has been linked to fetal growth.To evaluate the association between in utero PBDEs exposure, changes (growth regulatory genes), pathophysiology of growth (birth outcomes, retardation) a population-based pregnancy cohort study.This was nested case-control...
This retrospective cohort study assessed the annualized incidence rate (IR) of acute pancreatitis (AP) in a nationally representative US adult population, as well variation risk AP events across strata triglyceride (TG) levels.Data were obtained from IQVIA's Ambulatory Electronic Medical Records (EMR) database linked with its LRxDx Open Claims database. Inclusion criteria included ≥1 serum TG value during overlapping period EMR and claims databases, claim 12-month baseline period, ≥ 1 12...
Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies examined SNPs D-related other than the receptor (VDR) gene particularly not association retinoid X alpha (RXRA) which may be a key pathway gene. We conducted nested case-control study 734 cases 1435 individually matched controls from population-based prospective cohort study, Northern Sweden Mammary Screening Cohort. Tag functional were...
Many epidemiological studies have evaluated the health risks of ambient fine particulate matter (PM2.5). However, few investigated potential exposure misclassification caused by using PM2.5 concentrations as proxy for individual to in regions with high-level air pollution. This study aimed compare differences between personal and constituent concentrations, predict sixteen constituents. We collected 141 72-h filter samples from a panel 36 healthy non-smoking college students Shanghai, China....
Background: Trends/outcomes associated with National Comprehensive Cancer Network (NCCN)-recommended biomarker testing to guide advanced non-small-cell lung cancer (aNSCLC) treatment were assessed. Methods: Patients initiating first-line aNSCLC included using a nationwide electronic health record-derived database (1/1/2015-10/31/2021). Trends in pre-first-line (PD-L1, major genomic aberrations), factors and associations between outcomes Results: PD-L1/genomic aberration rates increased from...
Background: Epidemiological studies have observed protective effects of mid-upper arm circumference (MUAC) against all-cause mortality mostly in Western populations. However, evidence on cause-specific is limited. Methods: The sample included 19 575 adults from a population-based cohort study rural Bangladesh, who were followed up for an average 7.9 years mortality. Cox proportional hazards regression was used to evaluate the effect MUAC, as well joint body mass index (BMI) and risk death...