A5063896009- Asthma and respiratory diseases
- Economic and Financial Impacts of Cancer
- Hemoglobinopathies and Related Disorders
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Health Systems, Economic Evaluations, Quality of Life
- Renal cell carcinoma treatment
- Erythropoietin and Anemia Treatment
- Prostate Cancer Treatment and Research
- Inhalation and Respiratory Drug Delivery
- Lung Cancer Research Studies
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Iron Metabolism and Disorders
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medication Adherence and Compliance
- Cancer Treatment and Pharmacology
- Eosinophilic Disorders and Syndromes
- Herpesvirus Infections and Treatments
- Pharmaceutical Economics and Policy
- Epilepsy research and treatment
- Complement system in diseases
Analysis Group (United States)
2016-2025
Access to Wholistic and Productive Living Institute
2024
Ibero American University
2017-2023
Boston University
2012-2023
Amgen (United States)
2023
Group for Research in Decision Analysis
2005-2019
Harvard University
1998-2018
GTx (United States)
2018
Research Triangle Park Foundation
2017
GlaxoSmithKline (United States)
2009-2017
Objective To quantify the incidence of anemia and red blood cell (RBC) transfusion practice in critically ill patients to examine relationship RBC clinical outcomes. Design Prospective, multiple center, observational cohort study intensive care unit (ICU) United States. Enrollment period was from August 2000 April 2001. Patients were enrolled within 48 hrs ICU admission. Patient follow-up for 30 days, hospital discharge, or death, whichever occurred first. Setting A total 284 ICUs (medical,...
<b>Objectives: </b> The primary objective was to investigate whether nonadherence antiepileptic drugs (AEDs) is associated with increased mortality and the secondary examine increases risk of serious clinical events, including emergency department (ED) visits, hospitalizations, motor vehicle accident (MVA) injuries, fractures, head injuries. <b>Methods: A retrospective open-cohort design employed using Medicaid claims data from Florida, Iowa, New Jersey January 1997 through June 2006....
Digital measures of health status captured during daily life could greatly augment current in-clinic assessments for rheumatoid arthritis (RA), to enable better assessment disease progression and impact. This work presents results from weaRAble-PRO, a 14-day observational study, which aimed investigate how digital technologies (DHT), such as smartphones wearables, patient reported outcomes (PRO) determine RA severity in study 30 moderate-to-severe patients, compared matched healthy controls...
To study the impact of nonadherence to antiepileptic drugs (AEDs) on health care utilization and direct medical costs in a Medicaid population.A retrospective cohort design was employed using state claims data from Florida, Iowa, New Jersey during period January 1997 June 2006. Patients aged >or=18 years with one or more neurologist visit an epilepsy diagnosis two pharmacy for AEDs were included. Medication possession ratio (MPR) used evaluate AED adherence MPR >or= 0.80 considered adherent...
Objective To determine the relationship between packed red blood cell transfusion practice and development of ventilator-associated pneumonia (VAP). Design Secondary analysis a multicentered, prospective observational study in intensive care units United States. Setting A total 284 States were studied from August 2000 to April 2001. Patients without at unit admission who then required least 48 hrs mechanical ventilation considered risk for VAP. Measurements Main Results VAP was diagnosed...
We assessed the relationship between GnRH agonists and risk of clinical fractures in men with prostate cancer.Using a database medical claims from 16 large American companies we identified study group 3,779 cancer who received treatment agonist control 8,341 were not treated agonist. Men 1 or more for bone metastases excluded. The rates any fracture, hip fracture vertebral compared groups.The rate was 7.91/100 vs 6.55/100 person-years at did receive (relative 1.21, 95% CI 1.09 to 1.34)....
Summary: Purpose: Compulsory generic substitution of antiepileptic drugs (AEDs) may lead to adverse effects in epilepsy patients because seizure recurrence or increased toxicity. The study objectives were (a) quantify and compare the switchback rates from brand‐name AEDs versus non‐AEDs, (b) assess clinical implications switching branded Lamictal lamotrigine (LTG) whether signals exist suggesting outcome worsening. Methods: By using a public‐payer pharmacy‐claims database Ontario, Canada,...
Most women with moderate to severe vasomotor symptoms (VMS) are untreated. This retrospective matched-cohort study aims evaluate the healthcare resource utilization, work loss, and cost burden associated untreated VMS.Health insurance claims (1999-2011) were used match (1:1) VMS control using propensity score. Healthcare productivity loss (disability + medically related absenteeism), costs compared between cohorts.During 12-month follow-up, (n = 252,273; mean age, 56 y) had significantly...
This study evaluated the effects of initial versus delayed treatment with a drug combination on blood pressure (BP) control and risk cardiovascular (CV) events in hypertensive patients. Clinical trials suggest that time to BP is an important determinant long-term outcomes, but real-world evidence scarce. Using electronic medical charts (2005–2009), we retrospectively analyzed 1762 adult patients elevation initiating therapy matched 1:1 similar monotherapy later switched therapy. Incidence...
This study explored the blood transfusion patterns, SCD complications, utilization of iron chelation therapies (ICT), healthcare resource use, and costs in pediatric, transitioning (18 years old) adult patients with SCD.Data from Florida (1998-2009), New Jersey (1996-2009), Missouri (1997-2010), Kansas (2001-2009), Iowa (1998-2010) state Medicaid were used. Patients ≥2 diagnoses ≥1 event included. Rates events, proportion eligible receiving ICT calculated. eligibility was defined as ≥10...
Systemic corticosteroids are a leading cause of drug-related complications, yet little has been done to quantify the dose-response relationship between systemic corticosteroid exposure and complications in patients with severe asthma.To (a) evaluate risk developing corticosteroid-related by asthma (b) associated health care resource utilization costs.This is retrospective study using administrative claims data from large commercial database 2003 2014. Multivariate generalized estimating...
<h3>Objective:</h3> To quantify the clinical and economic burden of uncontrolled epilepsy in patients requiring emergency department (ED) visit or hospitalization. <h3>Methods:</h3> Health insurance claims from a 5-state Medicaid database (1997Q1–2009Q2) 55 self-insured US companies ("employer," 1999Q1 2008Q4) were analyzed. Adult with receiving antiepileptic drugs (AED) selected. Using retrospective matched-cohort design, categorized into cohorts "uncontrolled" (≥2 changes AED therapy, then...
Abstract Background. Octreotide LAR is used in patients for control of carcinoid syndrome (CS) and other symptoms hormone hypersecretion. The aim this study was to examine reasons octreotide dose escalation observe CS symptom improvement with neuroendocrine tumors (NETs) who underwent at three cancer referral centers. Methods. Medical records diagnosis or pancreatic NET had received one more above 30 mg every 4 weeks from 2000 2012 were reviewed. Reasons symptomatic outcomes abstracted each...
BACKGROUND Effective treatment options for patients with chronic myeloid leukemia (CML) or Philadelphia‐positive (Ph+) acute lymphoblastic (ALL) who have the threonine to isoleucine mutation at codon 315 (T315I) are few. The objective of this study was compare overall survival (OS) between CML and those Ph+ ALL received ponatinib versus allogeneic stem cell transplantation (allo‐SCT). METHODS A post hoc, retrospective, indirect comparison OS among single‐agent in Ponatinib Evaluation (PACE)...
This longitudinal, retrospective cohort study of patients with COPD describes baseline characteristics, adherence, and persistence following initiation inhaled corticosteroids (ICS)/long-acting β2-agonists (LABA)/long-acting muscarinic antagonists (LAMA) from multiple inhaler triple therapy (MITT).Patients aged ≥40 years receiving MITT between January 2012 September 2015 were identified the IQVIA™ Real-world Data Adjudicated Claims-USA database. was defined as subjects ≥1 overlapping days'...
Therapeutic options for metastatic castration-resistant prostate cancer (mCRPC) patients are continuously advancing. We described mCRPC treatment patterns in the US from 2013 to 2019. Patients with a confirmed diagnosis and adenocarcinoma histology were included Flatiron Health Electronic Record-derived de-identified database. Treatment [including per lines of therapies (LOTs), LOT sequences, time on treatment] overall survival (OS) have been settings. Of 5213 (mean age: 72.6 years), 4374...
USING DATA FROM the Second National Acute Spinal Cord Injury Study (NASCIS II), authors sought to characterize role of surgery in management traumatic spinal cord injury and examine interaction between pharmacological treatment surgery. Patients who did not undergo had more severe injuries initially than those However, no differences neurological improvement at 1-year follow-up were found underwent not. The results suggest that either early (≤ 25 hours after injury) or late (> 200 hours) may...
In Brief Objective: The aim of this study was to quantify the magnitude risk reduction for venous thromboembolism events associated with an estradiol transdermal system relative oral estrogen-only hormone therapy agents. Methods: A claims analysis conducted using Thomson Reuters MarketScan database from January 2002 October 2009. Participants 35 years or older who were newly two more dispensings analyzed. Venous defined as one diagnosis codes deep vein thrombosis pulmonary embolism. Cohorts...
Recent data indicate that transfusion of packed red blood cells (pRBCs) may increase the risk for development acute respiratory distress syndrome (ARDS) in critically ill patients. Uncertainty remains regarding strength this relationship.To quantify association between transfusions and intensive care unit (ICU)-onset ARDS, we performed a cohort study within Crit, multicenter, prospective, observational practice ICU which enrolled 4,892 patients 284 ICUs United States. Diagnostic criteria...