A5042603671- Dementia and Cognitive Impairment Research
- Diabetes Management and Research
- Diabetes Management and Education
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Frailty in Older Adults
- Diabetes Treatment and Management
- Peripheral Artery Disease Management
- Alzheimer's disease research and treatments
- Medication Adherence and Compliance
- Diabetic Foot Ulcer Assessment and Management
- Diagnosis and Treatment of Venous Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Venous Thromboembolism Diagnosis and Management
- Pressure Ulcer Prevention and Management
- Treatment of Major Depression
- Asthma and respiratory diseases
- Muscle Physiology and Disorders
- Wound Healing and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Global Health Care Issues
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and biosynthesis
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
MIT World Peace University
2025
Analysis Group (United States)
2015-2024
Atrium Medical Cente
2022-2024
Intel (United States)
2023
Boston University
2022
Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College
2016-2022
Lexicon Pharmaceuticals (United States)
2005-2021
Hershey (United States)
2018-2021
Eli Lilly (United States)
2017-2020
Eli Lilly (Canada)
2020
To estimate the annual, per-patient incremental burden of diabetic foot ulcers (DFUs).DFU patients and non-DFU with diabetes (controls) were selected using two de-identified databases: ages 65+ years from a 5% random sample Medicare beneficiaries (Standard Analytical Files, January 2007-December 2010) 18-64 privately insured population (OptumInsight, 2007-September 2011). Demographics, comorbidities, resource use, costs payer perspective incurred during 12 months prior to DFU episode...
Introduction This study estimated the minimal clinically important difference (MCID) for Mini Mental State Examination, Clinical Dementia Rating Scale sum of boxes, and Functional Activities Questionnaire across Alzheimer's disease (AD) spectrum. Methods Retrospective analysis National Coordinating Center Uniform Data Set (9/2005-9/2016) MCID clinical outcomes were using anchor-based (clinician's assessment meaningful decline) distribution-based (1/2 baseline standard deviation) approaches,...
To estimate the annual incremental per-patient and overall payer burden (2012USD) of venous leg ulcers (VLU) in US.Beneficiaries with without VLU were identified using two de-identified insurance claims databases: aged 65+ from a 5% random sample Medicare beneficiaries (2007-2010: n ∼ 2.3 million); 18-64 privately-insured population (2007-2011: 8.4 million). The index date was selected as claim no other diagnoses preceding 12 months for cohort medical non-VLU patients. These groups matched...
We used gene knockout mice to explore the role of Angiopoietin-like-4 (Angptl4) in lipid metabolism as well generate anti-Angptl4 mAbs with pharmacological activity. Angptl4 -/- had lower triglyceride (TG) levels resulting both from increased very low-density lipoprotein (VLDL) clearance and decreased VLDL production modestly cholesterol levels. Also, suckling adult fed a high-fat diet showed reduced viability associated lipogranulomatous lesions intestines their draining lymphatics...
Objectives: Although systemic glucocorticoids (SGCs) are efficacious, their chronic use is associated with a range of complications. Yet limited data available about the risks following in patients severe asthma, who at risk long-term SGC-related This study was carried out to investigate developing complications, and quantify healthcare resource utilization costs for asthma United States.Methods: longitudinal, open-cohort, observational study. Medicaid claims (1997–2013) ≥12 years old ≥2...
Abstract Introduction Recent developments in diagnostic technology can support earlier, more accurate diagnosis of non‐Alzheimer's disease (AD) dementias. Methods To evaluate potential economic benefits early rule‐out AD, annual medical resource use and costs for Medicare beneficiaries potentially misdiagnosed with AD prior to their vascular dementia (VD) or Parkinson's (PD) were compared that similar patients never diagnosed AD. Results Patients used substantially services every year until...
Abstract Background The current studies involve the development of a liquid chromatographic method that is highly effective (HPLC) for Lumateperone Tosylate simple, rapid, accurate, precise, and economical, all made possible by analytical quality design (AQbD). HPLC method’s experimental settings were multivariately optimised using experiments to determine critical parameters, Ishikawa diagram was used risk assessment. A two-factor, three-level factor screening investigations. Mathematical...
Congenital cytomegalovirus (cCMV) is the leading infectious cause of congenital birth defects. Although approximately 20% to 25% infants born with cCMV develop long-term health complications such as sensorineural hearing loss, developmental issues, and microcephaly, studies on disease burden are limited. In this study, we assessed epidemiology, economic burden, clinically diagnosed in United States using insurance claims data. This retrospective study utilized Merative MarketScan Commercial...
After creating >4650 knockouts (KOs) of independent mouse genes, we screened them by high-throughput phenotyping and found that cannabinoid receptor 1 (Cnr1) KO mice had the same lean phenotype published others. We asked if our KOs DAG lipase a or b (Dagla Daglb), which catalyze biosynthesis endocannabinoid (EC) 2-Arachidonoylglycerol (2-AG), Napepld, catalyzes EC anandamide, shared Cnr1 mice. Dagla mice, but not Daglb Napepld were among leanest 3651 chow-fed lines screened. In confirmatory...
To assess basal insulin persistence, associated factors, and economic outcomes for insulin-naïve people with type 2 diabetes mellitus (T2DM) in the US.People aged ≥18 years diagnosed T2DM initiating between April 2006 March 2012 (index date), no prior use, continuous insurance coverage 6 months before (baseline) 24 after index date (follow-up period) were selected using de-identified administrative claims data US. Based on whether there ≥30 day gaps use first year post-index, patients...
OBJECTIVE The goal of this study was to evaluate the association between timing treatment intensification and subsequent glycemic control among patients with type 2 diabetes in whom monotherapy fails. RESEARCH DESIGN AND METHODS This retrospective analysis U.K. Clinical Practice Research Datalink database focused on one or more HbA1c measurements ≥7% (≥53 mmol/mol) after ≥3 months metformin sulfonylurea (first measurement meeting these criteria taken as index date). Baseline (6 before date)...
Delta-5 desaturase (D5D) and delta-6 (D6D), encoded by fatty acid 1 (FADS1) FADS2 genes, respectively, are enzymes in the synthetic pathways for ω3, ω6, ω9 polyunsaturated acids (PUFAs). Although PUFAs appear to be involved mammalian metabolic pathways, physiologic effect of isolated D5D deficiency on these is unclear. After generating >4,650 knockouts (KOs) independent mouse genes analyzing them our high-throughput phenotypic screen, we found that Fads1 KO mice were among leanest 3,651...
Abstract Introduction This study evaluates rates of all‐cause emergency department visits, hospitalizations, potentially avoidable and falls in 3 years preceding Alzheimer's disease (AD) diagnosis. Methods Patients with AD controls no cognitive impairment were identified from the Medicare claims data. required to be aged ≥ 65 have continuous enrollment for ≥4 before index date (AD cohort: first diagnosis 2012–2014; controls: randomly selected medical claim). Outcomes each preindex year...
Objective To describe the trends in epidemiology, healthcare resource use (HCRU), and costs associated with Lewy body dementia (LBD), bodies (DLB), Parkinson's disease (PDD) United States.Methods This retrospective study used administrative claims data for Medicare fee-for-service (2010–2018) commercially-insured beneficiaries (2010–2017). The annual prevalence incidence were calculated among by dividing number of prevalent or incident LBD, DLB, PDD patients total eligible population that...
We developed a high-throughput approach to knockout (KO) and phenotype mouse orthologs of the 5,000 potential drug targets in human genome. As part phenotypic screen, dual-energy X-ray absorptiometry (DXA) technology estimates body-fat stores eight KO four wild-type (WT) littermate chow-fed mice from each line. Normalized % body fat (nBF) (mean fat/mean WT fat) values first 2322 lines with viable at 14 weeks age showed normal distribution. chose determine how well this screen identifies...
The kinase suppressor of ras 2 (KSR2) gene resides at human chromosome 12q24, a region linked to obesity and type diabetes (T2D). While knocking out phenotypically screening mouse orthologs thousands druggable genes, we found KSR2 knockout (KSR2(-/-)) mice be more obese glucose intolerant than melanocortin 4 receptor(-/-) (MC4R(-/-)) mice. T2D KSR2(-/-) resulted from hyperphagia which was unresponsive leptin did not originate downstream MC4R. kinases AMP-activated protein (AMPK) mammalian...
To examine the effect of Medicare Annual Wellness Visit (AWV) on detection cognitive impairment and follow-up care for older adults.Retrospective matched-cohort study.United States.A 5% random sample fee-for-service beneficiaries continuously enrolled 12 months before after an index ambulatory visit occurring from 2011 to 2013 with no claims evidence index.Outcomes include 12-month post-index claims-based measurements impairment, including new Alzheimer's disease related dementia (ADRD)...
It is not known if there a differential impact on Alzheimer's disease (AD) diagnosis and outcomes if/when patients are diagnosed with cognitive decline by specialists versus non-specialists. This study examined the cost trajectories of Medicare beneficiaries initially compared to similar who received their in primary care settings.Patients ≥2 claims for AD were selected from de-identified administrative data US (5 % random sample). The earliest observed served as index date. Patients...
Background:Telehealth has the potential to improve chronic disease management and outcomes, but data regarding direct benefit of telehealth in patients with heart failure (HF) have been mixed. The objective this study was determine whether Health Buddy Program (HBP) (Bosch Healthcare, Palo Alto, CA), a content-driven system coupled care management, is associated improved outcomes Medicare beneficiaries HF.Materials Methods:This retrospective cohort 623 HF offered HBP enrollment compared...
To identify actions of healthcare professionals (HCPs) that facilitate the transition to insulin therapy (IT) in type 2 diabetes (T2D) adults.Included were T2Ds seven countries (n = 594) who reported initial IT reluctance but eventually began IT. An online survey included 38 possible HCP actions: indicated which may have occurred and their helpfulness. Also delays start after recommendation any period discontinuation.Exploratory factor analysis yielded five factors: "Explained Insulin...