A5019055956- Dementia and Cognitive Impairment Research
- Intensive Care Unit Cognitive Disorders
- Geriatric Care and Nursing Homes
- Pharmaceutical Practices and Patient Outcomes
- Anesthesia and Sedative Agents
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Anesthesia and Neurotoxicity Research
- Family and Patient Care in Intensive Care Units
- Palliative Care and End-of-Life Issues
- Chronic Disease Management Strategies
- Blood Pressure and Hypertension Studies
- Health Policy Implementation Science
- Cholinesterase and Neurodegenerative Diseases
- Healthcare Decision-Making and Restraints
- Emergency and Acute Care Studies
- Schizophrenia research and treatment
- Electronic Health Records Systems
- Medication Adherence and Compliance
- Machine Learning in Healthcare
- Family Caregiving in Mental Illness
- Health and Medical Research Impacts
- Trauma and Emergency Care Studies
- Health disparities and outcomes
- Mental Health Treatment and Access
Indiana University – Purdue University Indianapolis
2016-2025
Indiana University School of Medicine
2016-2025
Regenstrief Institute
2016-2025
Indiana University Indianapolis
2007-2025
Eskenazi Health
2016-2025
Indiana University
2014-2025
Eskenazi Health Foundation
2016-2025
Center for Innovation
2014-2025
Indiana Clinical and Translational Sciences Institute
2017-2024
University School
2008-2024
Most older adults with dementia will be cared for by primary care physicians, but the practice environment presents important challenges to providing quality care.To test effectiveness of a collaborative model improve patients Alzheimer disease.Controlled clinical trial 153 disease and their caregivers who were randomized physician receive management (n = 84) or augmented usual 69) at practices within 2 US university-affiliated health systems from January 2002 through August 2004. Eligible...
OBJECTIVES: To determine whether the use of medications with possible and definite anticholinergic activity increases risk cognitive impairment mortality in older people is cumulative. DESIGN: A 2‐year longitudinal study participants enrolled Medical Research Council Cognitive Function Ageing Study between 1991 1993. SETTING: Community‐dwelling institutionalized participants. PARTICIPANTS: Thirteen thousand four aged 65 older. MEASUREMENTS: Baseline or anticholinergics determined according...
The Patient Protection and Affordable Care Act added a new Medicare benefit, the Annual Wellness Visit (AWV), effective January 1, 2011. AWV requires an assessment to detect cognitive impairment. Centers for Medicaid Services (CMS) elected not recommend specific tool because there is no single, universally accepted screen that satisfies all needs in detection of To provide primary care physicians with guidance on during AWV, when referral or further testing needed, Alzheimer's Association...
Inouye, Sharon K. MD, MPH; Robinson, Thomas MS, FACS; Blaum, Caroline MS; Busby-Whitehead, Jan CMD, AGSF; Boustani, Malaz Chalian, Ara MD; Deiner, Stacie Fick, Donna PhD, RN, FGSA, FAAN; Hutchison, Lisa PharmD; Johanning, Jason Katlic, Mark Kempton, James; Kennedy, Maura MD. Kimchi, Eyal Ko, Cliff Leung, Jacqueline Mattison, Melissa; Mohanty, Sanjay Nana, Arvind Needham, Dale PhD; Neufeld, Karin Richter, Holly MD The American Geriatrics Society Expert Panel on Postoperative Delirium in Older...
To estimate the association between duration and level of exposure to different classes anticholinergic drugs subsequent incident dementia.Case-control study.General practices in UK contributing Clinical Practice Research Datalink.40 770 patients aged 65-99 with a diagnosis dementia April 2006 July 2015, 283 933 controls without dementia.Daily defined doses coded using Anticholinergic Cognitive Burden (ACB) scale, total grouped by subclass, prescribed 4-20 years before dementia.Odds ratios...
Delirium severity is independently associated with longer hospital stays, nursing home placement, and death in patients outside the ICU. ICU not routinely measured because available instruments are difficult to complete critically ill patients. We designed our study assess reliability validity of a new delirium tool, Confusion Assessment Method for ICU-7 scale.Observational cohort study.Medical, surgical, progressive ICUs three academic hospitals.Five hundred eighteen adult (≥ 18 yr)...
Considering the increasing proportion of residents in long-term care who have dementia, and important influence that direct providers on resident quality life, this study explores dementia-related attitudes residential care/assisted living (RC/AL) nursing home staff, as well their work stress satisfaction.Data were derived from interviews with 154 31 RC/AL facilities 10 homes participated Collaborative Studies Long-Term Care.Stress was more often reported by had been working for 1 to 2 years...
OBJECTIVES: To compare the medical comorbidity of older patients with and without dementia in primary care. DESIGN: Cross‐sectional study. SETTING: Wishard Health Services, which includes a university‐affiliated, urban public hospital seven community‐based care practice centers Indianapolis. PARTICIPANTS: Three thousand thirteen aged 65 attending Indianapolis, Indiana. MEASUREMENTS: An expert panel diagnosed using International Classification Diseases, 10th Revision , criteria. Comorbidity...
Purpose: There are few empirical studies relating components of long-term care to quality life for residents with dementia. This study relates elements dementia in residential care/assisted living (RC/AL) facilities and nursing homes resident considers the guidance this information provides practice policy. Design Methods: We used a variety report observational measures structure process 11 standardized evaluate 421 35 RC/AL 10 four states. Data were collected cross sectionally on-site, we...
Older Americans are facing an epidemic of chronic diseases and thus exposed to anticholinergics (ACs) that might negatively affect their risk developing mild cognitive impairment (MCI) or dementia.
<b>Background:</b> Anticholinergic properties of certain medications often go unrecognized, and are frequently used by the elderly population. Few studies have yet defined long-term impact these on incidence cognitive impairment. <b>Methods:</b> We report a 6-year longitudinal, observational study, evaluating 1,652 community-dwelling African American subjects over age 70 years who were enrolled in Indianapolis-Ibadan Dementia Project between 2001 2007 had normal function at baseline. The...
Background Agitation in Alzheimer's disease (AD) is common and associated with poor patient life-quality carer distress. The best evidence-based pharmacological treatments are antipsychotics which have limited benefits increased morbidity mortality. There no memantine trials clinically significant agitation but post-hoc analyses other populations found reduced agitation. We tested the primary hypothesis, superior to placebo for agitation, patients moderate-to-severe AD. Methods Findings...
Background: Recent randomized controlled trials have demonstrated the effectiveness of collaborative dementia care model targeting both patients suffering from and their informal caregivers. Objective: To implement a sustainable program in public health system Indianapolis. Methods: We used framework Complex Adaptive System tool Reflective Process to translate results trial into Healthy Aging Brain Center (HABC). Results: Within its first year operation, HABC delivered 528 visits serve 208...