A5026262000- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Asthma and respiratory diseases
- Metabolism, Diabetes, and Cancer
- Fish Ecology and Management Studies
- Neurogenetic and Muscular Disorders Research
- Hydrology and Watershed Management Studies
- Inhalation and Respiratory Drug Delivery
- Genetic Neurodegenerative Diseases
- Cancer Risks and Factors
- Pancreatic and Hepatic Oncology Research
- Family and Disability Support Research
- Colorectal Cancer Screening and Detection
- Acute Lymphoblastic Leukemia research
- Lipoproteins and Cardiovascular Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Medication Adherence and Compliance
- Rheumatoid Arthritis Research and Therapies
- Neurological disorders and treatments
- Congenital Anomalies and Fetal Surgery
- Esophageal Cancer Research and Treatment
- Dermatology and Skin Diseases
- Potassium and Related Disorders
- Autoimmune and Inflammatory Disorders Research
- Cystic Fibrosis Research Advances
Pfizer (United States)
2020-2024
Environmental Protection Agency
2000-2022
Roche (Canada)
2020-2022
Group for Research in Decision Analysis
2018-2020
McGill University
2014-2018
Jewish General Hospital
2014-2018
Division of Cancer Epidemiology and Genetics
2013-2014
AARP
2013-2014
National Institutes of Health
2012-2013
National Cancer Institute
2011-2013
This longitudinal, retrospective cohort study of patients with COPD describes baseline characteristics, adherence, and persistence following initiation inhaled corticosteroids (ICS)/long-acting β2-agonists (LABA)/long-acting muscarinic antagonists (LAMA) from multiple inhaler triple therapy (MITT).Patients aged ≥40 years receiving MITT between January 2012 September 2015 were identified the IQVIA™ Real-world Data Adjudicated Claims-USA database. was defined as subjects ≥1 overlapping days'...
Spinal muscular atrophy (SMA) is a rare neurodegenerative disease characterized by progressive weakness, which occurs in one 6,000 to 10,000 live births. The burden of SMA on Canadian patients and caregivers not known.
Purpose The association between long-acting insulin analogs and increased breast cancer risk is uncertain, particularly with the short follow-up in previous studies. We assessed this long term women type 2 diabetes. Methods A population-based cohort of 40 years or older, all whom were treated (glargine, detemir) neutral protamine Hagedorn (NPH) 2002 2012, was formed using United Kingdom's Clinical Practice Research Datalink. Women followed until February 2015 diagnosis. Cox proportional...
Despite many studies on diet and bladder cancer, there are areas that remain unexplored including meat mutagens, specific vegetable groups, vitamins from diet. We conducted a population-based case–control study of cancer in Maine, New Hampshire, Vermont. A total 1171 cases were ascertained through hospital pathology records registries 2001 to 2004. Overall, 1418 controls identified the Department Motor Vehicles (<65 years) Center for Medicaid Medicare Services (65–79 frequency-matched by...
This real-world observational study compared medication adherence and persistence among patients with asthma receiving the once-daily inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) fluticasone furoate/vilanterol (FF/VI) versus twice-daily ICS/LABAs budesonide/formoterol (B/F) propionate/salmeterol (FP/SAL).This retrospective cohort conducted using IQVIATM Health Plan Claims Data included ≥18 years of age initiating ICS/LABA therapy FF/VI, B/F, or FP/SAL between January 1, 2014 June...
Aside from exposure to ionizing radiation and benzene, little is known about lifestyle risk factors for chronic myeloid leukemia (CML) in the general population.
OBJECTIVE To determine whether the use of glyburide is associated with an increased risk cancer compared other second-generation sulfonylureas among patients type 2 diabetes. RESEARCH DESIGN AND METHODS The U.K. Clinical Practice Research Datalink was used to conduct a cohort study 52,600 newly prescribed or between 1 January 1988 and 31 July 2013. A time-dependent Cox proportional hazards model estimate adjusted hazard ratios (HRs) 95% CIs any sulfonylureas. Secondary analyses were...
Abstract Background The objective of this study was to investigate real-world EGFR mutation testing in patients with metastatic non-small cell lung cancer (NSCLC) upon progression on first−/second-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI), and subsequent treatments received. Methods Flatiron Health electronic health records-derived database used identify adult NSCLC treated EGFR-TKI from 11/2015–09/2017, start first defined as the index date....
To evaluate the epidemiology, healthcare resource utilization, and direct costs associated with Huntington's disease in a Canadian setting universal system.Using Albertan administrative health data, retrospective cohort was identified applying an algorithm requiring two HD diagnostic codes within years, using first record as index date (i.e. proxy for diagnosis date), from 1 April 2010 to 31 March 2019 patients ≥21 years old. Incidence/prevalence measures were evaluated 2019, while...
Abstract The importance of thermal refuges in a rapidly warming world is particularly evident for migratory species, where individuals encounter wide range conditions throughout their lives. In this study, we used spatially explicit, individual‐based simulation model to evaluate the buffering potential cold‐water anadromous salmon and trout ( Oncorhynchus spp.) migrating upstream through warm river corridor that can expose physiologically stressful temperatures. We considered migration...
Tiotropium bromide (TIO) is a long-acting muscarinic antagonist recommended as an add-on therapy option for patients with uncontrolled asthma on inhaled corticosteroids (ICS) and β2-agonists (LABA). However, real-world data TIO use in remains limited. To identify unmet needs, this study explored the of US asthma.This retrospective cohort used IQVIATM Health Plan Claims Data (October 1, 2014─December 31, 2016). Patients diagnoses initiating 1.25 or 2.5 mcg after September 16, 2015 (first...
Abstract Purpose The effect of statins on cytokine‐mediated inflammatory responses may impact the prognosis influenza. We assessed whether statin use decreases incidence adverse influenza‐related outcomes. Additionally, we used a new‐user study design to minimize healthy user bias. further examined possibility non‐causal associations by using unrelated Methods UK Clinical Practice Research Datalink identify all patients aged 30 or older diagnosed with influenza‐like illness during 1997–2010....
Diadromous fish populations face multiple challenges along their migratory routes. These include suboptimal water quality, harvest, and barriers to longitudinal lateral connectivity. Interactions among factors influencing migration success make it challenging assess management options for improving conditions riverine corridors. We describe a spatially explicit simulation model that integrates complex individual behaviors of fall-run Chinook Salmon (Oncorhynchus tshawytscha) summer-run...
Real-world data on the clinical outcomes of heart failure (HF) across spectrum ejection fraction (EF) and prognostic value B-type natriuretic peptide (BNP) have not been well examined.The real-world association between HF EF or BNP levels may differ different values.The Optum Integrated Claims-Clinical (07/2009-09/2016) was used to identify adult patients with ≥1 diagnosis during hospitalization emergency room visit. Three cohorts were formed: reduced (rEF; < 40%), mid-range (mrEF; 40%-49%),...
Our objective was to assess healthcare resource utilization (HRU) and costs among patients with major depressive disorder (MDD) without treatment-resistant depression (TRD) those MDD in US Integrated Delivery Networks (IDNs). This a retrospective matched-cohort study. The Optum© Claims Electronic Health Record de-identified database used identify adult TRD (January 2011–June 2017) across IDNs. were propensity score matched 1:1 non-TRD non-MDD on demographics. Rates of HRU compared up 2 years...
Abstract Background Pregnant women with ulcerative colitis (UC) have a higher risk of adverse pregnancy outcomes vs age-matched controls.1 Tofacitinib is an oral Janus kinase inhibitor for the treatment UC. There are no well-controlled studies on tofacitinib use in pregnant women. It was shown to be teratogenic rats and rabbits at approximately 73 6.3 times, respectively, maximum recommended human dose 10 mg twice daily. affects female fertility, parturition peri/postnatal development...
Abstract Purpose To validate three approaches for identifying incident cases of pancreatic cancer in Ontario administrative claims data. Methods We created a cohort using (Canada) health data from 2002 to 2012 and identified with approaches, the Cancer Registry (OCR) as reference standard. In any diagnosis approach, were defined by primary or secondary diagnostic codes outpatient inpatient records. only diagnoses hospital discharge abstracts. algorithm an that combined first two approaches....
Aims Spinal muscular atrophy (SMA) is a progressive neuromuscular disease associated with the degeneration of motor neurons in brainstem and spinal cord. Studies examining epidemiology economic impact SMA are limited Canada. This study aimed to estimate as well healthcare resource utilization (HRU) costs for children Alberta, Canada.Materials methods We conducted retrospective using anonymized data from administrative databases provided by Alberta Health. Data 1 April 2010 31 March 2018,...