A5084512170- Congenital Heart Disease Studies
- Lung Cancer Treatments and Mutations
- Melanoma and MAPK Pathways
- Cardiac Structural Anomalies and Repair
- Cancer Immunotherapy and Biomarkers
- Cutaneous Melanoma Detection and Management
- HER2/EGFR in Cancer Research
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Issues in Pregnancy
- Tuberous Sclerosis Complex Research
- Prostate Cancer Treatment and Research
- Advanced Breast Cancer Therapies
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Multiple and Secondary Primary Cancers
- Coronary Artery Anomalies
- Cardiovascular and Diving-Related Complications
- Healthcare Policy and Management
- Economic and Financial Impacts of Cancer
- Emergency and Acute Care Studies
- Musculoskeletal synovial abnormalities and treatments
Statistics Canada
2023-2025
Analysis Group (United States)
2013-2022
Group for Research in Decision Analysis
2013-2021
Daiichi Sankyo (Germany)
2021
Daiichi-Sankyo (South Korea)
2021
Daiichi Sankyo (United States)
2021
Rothman Institute
2021
Fox Chase Cancer Center
2021
Creative Commons
2021
Roche (Switzerland)
2020
Background— Empirical data on the changing epidemiology of congenital heart disease (CHD) are scant. We determined prevalence, age distribution, and proportion adults children with severe other forms CHD in general population from 1985 to 2000. Methods Results— Where healthcare access is universal, we used administrative databases that systematically recorded all diagnoses claims. Diagnostic codes conformed International Classification Disease , ninth revision. Severe was defined as...
Background— Our objective was to obtain contemporary lifetime estimates of congenital heart disease (CHD) prevalence using population-based data sources up year 2010. Methods and Results— The Quebec CHD database contains 28 years longitudinal on all individuals with from 1983 Severe defined as tetralogy Fallot, truncus arteriosus, transposition complexes, endocardial cushion defects, univentricular hearts. We used latent class bayesian models combining case definitions physician claims,...
Background— Atrial arrhythmias increase disease burden in the general adult population. Adults with congenital heart lesions constitute a rapidly growing group of patients cardiovascular disease. We hypothesized that atrial age and impair health outcomes this Methods Results— conducted population-based analysis prevalence, lifetime risk, mortality, morbidity associated adults from l983 to 2005. In 38 428 2005, 5812 had arrhythmias. Overall, 20-year risk developing arrhythmia was 7%...
Background— Clinical guidelines recommend specialized care for adult congenital heart disease (ACHD) patients. In reality, few patients receive such dedicated care. We sought to examine the impact of on ACHD patient mortality. Methods and Results— examined referral rates centers mortality between 1990 2005 in population-based Quebec Congenital Heart Disease database (n=71 467). This period covers several years before after publication endorsing A time-series design, based Joinpoint Poisson...
Background— Many patients with congenital heart disease (CHD) require lifelong care. However, the duration of cardiology follow-up in children and adults CHD is unknown. We sought to determine proportion young receiving outpatient care identify predictors lack follow-up. Methods Results— The study population consisted individuals born 1983 alive at age 22 years who were diagnosed Quebec, Canada, before 6 (n=643). Patients visits identified use provincial physician’s claims database. Three...
<b>Background:</b> People aged 65 years or more represent a growing group of emergency department users. We investigated whether characteristics primary care (accessibility and continuity) are associated with use by elderly people in both urban rural areas. <b>Methods:</b> conducted cross-sectional study using information for random sample 95 173 drawn from provincial administrative databases Quebec 2000 2001. obtained data on the patients9 age, sex, comorbidity, rate (number days which...
<b>Objective</b> To investigate whether the 1998 government policy for mandatory fortification of flour and pasta products with folate was followed by a reduction in prevalence severe congenital heart defects. <b>Design</b> Time trend analysis. <b>Setting</b> Province Quebec, Canada. <b>Participants</b> Infants born 1990-2005 identified defects (tetralogy Fallot, endocardial cushion defects, univentricular hearts, truncus arteriosus, or transposition complexes) Quebec administrative...
The American Heart Association guidelines for prevention of infective endocarditis (IE) in 2007 reduced the groups congenital heart disease (CHD) patients whom antibiotic prophylaxis was indicated. evidence base CHD is limited. We sought to determine risk IE children with CHD.We performed a population-based analysis cumulative incidence and predictors (0-18 years) by use Quebec Database from 1988 2010. In 47 518 followed 458 109 patient-years, 185 cases were observed. Cumulative estimated...
Controversy continues concerning the choice of rhythm control vs rate treatment strategies for atrial fibrillation (AF). A recent clinical trial showed no difference in 5-year mortality between 2 treatments. We aimed to determine whether have similar effectiveness when applied a general population patients with AF longer follow-up.We used population-based administrative databases from Quebec, Canada, 1999 2007 select 66 years or older hospitalized an diagnosis who did not AF-related drug...
Therapeutic options for metastatic castration-resistant prostate cancer (mCRPC) patients are continuously advancing. We described mCRPC treatment patterns in the US from 2013 to 2019. Patients with a confirmed diagnosis and adenocarcinoma histology were included Flatiron Health Electronic Record-derived de-identified database. Treatment [including per lines of therapies (LOTs), LOT sequences, time on treatment] overall survival (OS) have been settings. Of 5213 (mean age: 72.6 years), 4374...
Aortic coarctation (CoA) is reported to predispose coronary artery disease (CAD). However, our clinical observations do not support this premise. Our objectives were describe the prevalence of CAD among adults with CoA and determine whether an independent predictor or premature CAD.The study population was derived from Quebec Congenital Heart Disease Database. We compared patients those a ventricular septal defect, who are known be at increased risk CAD. The in defect determined. then used...
Daclatasvir (DCV) is a potent, pangenotypic nonstructural protein 5A inhibitor with demonstrated antiviral efficacy when combined sofosbuvir (SOF) or simeprevir (SMV) without ribavirin (RBV) in patients chronic hepatitis C virus (HCV) infection. Herein, we report and safety data for DCV-based all-oral therapy liver transplantation (LT) recipients severe recurrent HCV. DCV at 60 mg/day was administered up to 24 weeks as part of compassionate use protocol. The study included 97 LT mean age...
Objective:Chronic myeloid leukemia (CML) treatment relies on tyrosine kinase inhibitors (TKIs), but their use can be associated with low-grade adverse events (AEs). This analysis aimed to identify the AEs which significantly impact Health Related Quality of Life (HRQoL) CML patients in chronic phase (CP) and compare incidence such among nilotinib- imatinib-treated patients.Research design methods:Data from 48 month ENESTnd trial were used (N = 593 patients). HRQoL was assessed using generic...
The burden of low-dose ionizing radiation (LDIR) exposure from medical procedures among individuals with congenital heart disease (CHD) is unknown. In this longitudinal population-based study, we sought to determine LDIR-related cardiac imaging and therapeutic in children adults CHD.In an analysis the Quebec CHD database, following was recorded: catheter-based diagnostic procedures, structural interventions, coronary computed tomography scans chest, nuclear pacemaker/implantable...