A5058719355- Atrial Fibrillation Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Schizophrenia research and treatment
- Diabetes Treatment and Management
- Economic and Financial Impacts of Cancer
- Statistical Methods in Clinical Trials
- Statistical Methods and Inference
- Systemic Lupus Erythematosus Research
- Musculoskeletal synovial abnormalities and treatments
- Colorectal Cancer Treatments and Studies
- Pharmaceutical industry and healthcare
- Cardiac Arrhythmias and Treatments
- Medication Adherence and Compliance
- Mental Health and Psychiatry
- Diabetes Management and Research
- Mental Health Treatment and Access
- Bone Tumor Diagnosis and Treatments
- Rheumatoid Arthritis Research and Therapies
- Cardiovascular Disease and Adiposity
- Pancreatic function and diabetes
- Pharmaceutical studies and practices
- Statistical Methods and Bayesian Inference
- Healthcare Operations and Scheduling Optimization
- Treatment of Major Depression
- Atherosclerosis and Cardiovascular Diseases
Syneos Health (United States)
2024-2025
The University of Texas Southwestern Medical Center
2023
Analysis Group (United States)
2018-2021
Rothman Institute
2021
Fox Chase Cancer Center
2021
Creative Commons
2021
Daiichi Sankyo (United States)
2021
Daiichi-Sankyo (South Korea)
2021
Daiichi Sankyo (Germany)
2021
SickKids Foundation
2018
To determine the effect of glucocorticoids (GCs) on acute myocardial infarction (MI) risk in patients with RA.Using administrative health data, we conducted a population-based cohort study 8384 incident RA cases (1997-2006). Primary exposure was GC use. MI events were ascertained using hospitalization and vital statistics data. We used Cox proportional-hazards models modelled use as four alternative time-dependent variables (current use, current dose, cumulative dose duration), adjusting for...
Controversy continues concerning the choice of rhythm control vs rate treatment strategies for atrial fibrillation (AF). A recent clinical trial showed no difference in 5-year mortality between 2 treatments. We aimed to determine whether have similar effectiveness when applied a general population patients with AF longer follow-up.We used population-based administrative databases from Quebec, Canada, 1999 2007 select 66 years or older hospitalized an diagnosis who did not AF-related drug...
Adherence to oral anticoagulant (OAC) agents is important for patients with nonvalvular atrial fibrillation (NVAF) prevent potentially severe adverse events.To compare real-world adherence rates and time discontinuation rivaroxaban versus other OACs (apixaban, dabigatran, warfarin) among NVAF using claims-based data.Health care claims from the IMS Health Real-World Data Adjudicated Claims database (July 2012-June 2015) were analyzed. rate was defined as percentage of proportion days covered...
Cox's proportional hazards (PH) model assumes constant‐over‐time covariate effects. Furthermore, most applications assume linear effects of continuous covariates on the logarithm hazard. Yet, many prognostic factors have time‐dependent (TD) and/or nonlinear (NL) effects, that is, violate these conventional assumptions. Detection such complex could affect prognosis and clinical decisions. However, assessing each multiple, often correlated, in flexible multivariable analyses is challenging. In...
Clozapine remains the antipsychotic of choice for people who, having met criteria a diagnosis schizophrenia or related psychotic disorder, do not respond adequately to other medications. Utilization rates appear highly variable across jurisdictions, with an overall tendency toward underuse. This paper describes patterns clozapine use in province Québec, Canada.Individuals were identified using linked government medical claims and hospitalization records 2003 2004. Linked data on their filled...
Background Medication non-adherence can result in poor health outcomes. Understanding differences adherence rates to non-vitamin K oral anticoagulants (NOACs) could guide treatment decisions and improve clinical outcomes among patients with non-valvular atrial fibrillation (NVAF). Objective To compare rivaroxaban apixaban the overall NVAF population subgroups of prior anticoagulant (OAC) users (e.g., multiple comorbidities, risk factors). Methods Using healthcare claims from Truven Health...
Since May 2015, adult patients with schizophrenia adequately treated once monthly paliperidone palmitate (PP1M) may be transitioned to once-every-three-months (PP3M). This study aims describe baseline characteristics and treatment patterns of initiated on PP3M in a real-world setting.Pharmacy medical claims from 2014 September 2016 for (index date) the Symphony Health Solutions database were analyzed. The cohort consisting all one restricted those transitioning PP1M as per prescribing...
<h3>Objectives</h3> We investigated the association between workplace lead exposure and lung cancer risk, separately for organic inorganic lead, from either engine emissions or other sources. <h3>Methods</h3> Two population-based case-control studies were carried out in Montreal (1979–1986 1996–2002) to investigate occupational factors relation among 1593 men with histologically confirmed incident cancer, 1426 controls general population. Interviews elicited information on sociodemographic...
Trifluridine/tipiracil (FTD/TPI) and regorafenib (REG) prolong survival in refractory metastatic colorectal cancer (mCRC) have similar indications with different side-effect profiles. The present study compared real-world treatment patterns FTD/TPI REG for mCRC a large, representative US claims database.Retrospective data from the Symphony Health Solutions' Integrated Dataverse database were analyzed adult patients receiving or October 2014 to July 2016. index date was first prescription...
Abstract Many exposures investigated in epidemiological case–control studies may vary over time. The effects of these are usually estimated using logistic regression, which does not directly account for changes covariate values time within individuals. By contrast, the Cox model with time‐dependent covariates accounts However, over‐sampling cases studies, relative to controls, requires manipulating risk sets partial likelihood. A previous study showed that simple inclusion or exclusion...
Objective. Persistent systemic lupus erythematosus (SLE) disease activity is associated with increased morbidity and mortality. In a multicenter cohort of patients prevalent SLE, we described persistence, patterns, predictors change in over time. Methods. Based on SLE Disease Activity Index (SLEDAI)-2K scores at entry, were classified into 4 groups: low (score < 4; LOW), moderate (4 to 6; MOD), moderately high (6 ≤ 10; MHIGH), very (> VHIGH). Multivariable linear longitudinal mixed...
Objectives This study had two aims: to measure the prevalence of long-term prescribing high doses antipsychotics and antipsychotic polypharmacy in a large Canadian province estimate relative contributions patient-, physician-, hospital-level factors. Methods Government hospital discharge, physician, pharmaceutical claims data were linked identify individuals with schizophrenia who 2004 available them for at least 11 months. Individuals on dose throughout that period, as well multiple...
To assess weight loss and cardiorenal outcomes by baseline body mass index (BMI) in VERTIS CV.
Prognostic studies often estimate survival curves for patients with different covariate vectors, but the validity of their results depends largely on accuracy estimated effects. To avoid conventional proportional hazards and linearity assumptions, flexible extensions Cox's model incorporate non-linear (NL) and/or time-dependent (TD) However, impact estimation is unclear. Our primary goal to develop validate a method estimating individual patients' curves, conditional multiple predictors...
Standard optimization algorithms for maximizing likelihood may not be applicable to the estimation of those flexible multivariable models that are nonlinear in their parameters. For applications where model's structure permits separating mutually exclusive subsets parameters into distinct steps, we propose alternating conditional (ACE) algorithm. We validate algorithm, simulations, two extensions Cox's proportional hazards model standard maximum partial does apply, with simultaneous modeling...
Objective: To evaluate the impact of a 0.2% reduction in glycated hemoglobin (HbA1c) on treatment intensification, poor HbA1c control and goal attainment patients with type 2 diabetes mellitus (T2DM) initiated sodium glucose co-transporter (SGLT2) inhibitor (SGLT2i).Methods: IQVIATM Health Plan Claims Data - US Ambulatory EMR databases (29 October 2012-31 March 2016) were used to identify adults T2DM an SGLT2i (index date) who had measurements pre- post-index, ≥6 months eligibility pre-index...
Objective: To assess the economic burden of tenosynovial giant cell tumor (TGCT) among US employed workforce. Methods: Patients with TGCT medical claims ( N = 1395) and matched controls (1:10) without 13,950) were identified from OptumHealth Care Solutions, Inc. database (January 1, 1999 to March 31, 2017). Adjusted regression models used compare healthcare resource utilization, time lost work, associated costs between cohorts. Results: In patients TGCT, rates inpatient admissions, emergency...