A5036864107- Genomics and Rare Diseases
- Retinal Imaging and Analysis
- Toxoplasma gondii Research Studies
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Colorectal Cancer Screening and Detection
- Health Systems, Economic Evaluations, Quality of Life
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Connective tissue disorders research
- COVID-19 Clinical Research Studies
- Brain Metastases and Treatment
- Herpesvirus Infections and Treatments
- Respiratory Support and Mechanisms
- Cytomegalovirus and herpesvirus research
- Intensive Care Unit Cognitive Disorders
- Multiple Sclerosis Research Studies
- Genetic factors in colorectal cancer
- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Healthcare Systems and Practices
- Cardiac Valve Diseases and Treatments
Inserm
2016-2025
Université de Bourgogne
2016-2025
CHU Dijon Bourgogne
2015-2024
Maison des Sciences de l’Homme de Dijon
2013-2024
Université Bourgogne Franche-Comté
2017-2024
Centre d’Investigation Clinique 1436
2015-2023
Centre de recherche Translationnelle en Médecine moléculaire
2015-2023
Clinical Investigation Center Plurithematic Tours
2009-2022
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2022
Université de Lorraine
2022
Uncontrolled studies suggest that chemoradiation has similar efficacy as surgery for esophageal cancer. Therefore, a randomized trial was carried out to compare, in responders only, alone with followed by patients locally advanced tumors.Eligible had operable T3N0-1M0 thoracic Patients received two cycles of fluorouracil (FU) and cisplatin (days 1 5 22 26) either conventional (46 Gy 4.5 weeks) or split-course (15 Gy, days concomitant radiotherapy. response no contraindication treatment were...
Acute kidney injury is the most frequent complication in patients with septic shock and an independent risk factor for death. Although renal-replacement therapy standard of care severe acute injury, ideal time initiation remains controversial. In a multicenter, randomized, controlled trial, we assigned early-stage who had at failure stage risk, failure, loss, end-stage disease (RIFLE) classification system but without life-threatening complications related to receive either within 12 hours...
Background. Toxoplasma infection during pregnancy exposes the fetus to risks of congenital and sequelae that depend heavily on gestational age (GA) at time infection. Accurate risk estimates by GA are necessary counsel parents improve clinical decisions. Methods. We analyzed data from pregnant women diagnosed with acute in Lyon (France) 1987 2008 assessed how toxoplasmosis signs 3 years vary depending maternal Results. Among 2048 mother-infant pairs, 93.2% mothers received prenatal treatment...
Objective. Retinochoroiditis is the most frequent consequence of congenital toxoplasmosis. Early diagnosis and treatment are believed to reduce risk visual impairment. We report on clinical evolution ocular lesions final function in a prospective cohort congenitally infected children who were identified during monthly maternal prenatal screening. Methods. The study included 327 monitored for up 14 years at Croix Rousse Hospital Lyon, France. Data date infection; time type therapy; antenatal,...
Abstract Introduction To provide up-to-date information on the prognostic factors associated with 28-day mortality in a cohort of septic shock patients intensive care units (ICUs). Methods Prospective, multicenter, observational study ICUs from 14 French general (non-academic) and university teaching hospitals. All consecutive admitted between November 2009 March 2011 were eligible for inclusion. We prospectively recorded data regarding patient characteristics, infection, severity illness,...
Because of the aging population and a rise in number stroke survivors, prevalence post-stroke cognitive impairment (PSCI) is increasing.To identify factors associated with 3-month PSCI.All consecutive patients without pre-stroke dementia, mild disorders, or severe aphasia hospitalized Neurology Department Dijon, University Hospital, France (November 2010 - February 2012) were included this prospective cohort study. Demographics, vascular risk factors, data collected. A first evaluation was...
Multiple endocrine neoplasia Type-1 (MEN1) in young patients is only described by case reports.To improve the knowledge of MEN1 natural history before 21 years old.Obtain a description first symptoms occurring old (clinical symptoms, biological or imaging abnormalities), surgical outcomes related to Neuro Endocrine Tumors (NETs) group 160 extracted from "Groupe d'étude des Tumeurs Endocrines" cohort.The were hyperparathyroidism 122 cases (75%), pituitary adenoma 55 (34%), nonsecreting...
From a large series of 1009 probands with pathogenic FBN1 mutations, data for 320 patients <18 years age at the last follow-up evaluation were analyzed (32%). At time diagnosis, median was 6.5 years. examination, population classified as follows: neonatal Marfan syndrome, 14%; severe 19%; classic 32%; probable 35%. Seventy-one percent had ascending aortic dilation, 55% ectopia lentis, and 28% major skeletal system involvement. Even when complications existed in childhood, rates surgery...
AimsIn patients with Marfan syndrome and other type-1 fibrillinopathies, genetic testing is becoming more easily available, leading to the identification of mutations early in course disease. This study evaluates cardiovascular (CV) risk associated discovery a fibrillin-1 (FBN1) mutation.
To assess whether early thrombocytopenia during septic shock is associated with an increased risk of death at day 28 and to identify factors a low platelet count.Prospective, multicenter, observational cohort study.Fourteen ICUs from 10 French university teaching nonacademic hospitals.Consecutive adult patients admitted between November 2009 September 2011 were eligible.None.Of the 1,495 eligible patients, 1,486 (99.4%) included. Simplified Acute Physiology Score II score greater than or...
Background: Intra-abdominal infections are frequent and life-threatening complications after colorectal surgery. An early detection could diminish their clinical impact permit safe discharge. Objective: This study aimed to find the most accurate marker for of postoperative intra-abdominal infection appropriate moment measure it. Methods: A prospective, observational was conducted in 3 centers. Consecutive patients undergoing elective surgery with anastomosis were included. C-reactive protein...
Abstract Introduction The mortality benefit of whole-body computed tomography (CT) in early trauma management remains controversial and poorly understood. objective this study was to assess the impact CT compared with selective on patients severe blunt trauma. Methods FIRST (French Intensive care Recorded Severe Trauma) is a multicenter cohort consecutive requiring admission intensive units from university hospital centers within first 72 hours. Initial data were combined construct...
ABSTRACT Exosomes are nanovesicles released by all cells that can be found in the blood. A key point for their use as potential biomarkers cancer is to differentiate tumour‐derived exosomes from other circulating nanovesicles. Heat shock protein‐70 (HSP70) has been shown abundantly expressed and associated with bad prognosis. We previously showed derived carried HSP70 membrane while those non‐cancerous did not. In this work, we opened a prospective clinical pilot study including breast lung...
Abstract Background COVID-19-related ARDS has unique features when compared with from other origins, suggesting a distinctive inflammatory pathogenesis. Data regarding the host response within lung are sparse. The objective is to compare alveolar and systemic inflammation patterns, mitochondrial alarmin release, outcomes according etiology (i.e., COVID-19 vs. non-COVID-19). Methods Bronchoalveolar lavage fluid plasma were obtained 7 control, non-COVID-19 ARDS, 14 patients. Clinical data,...
The COVID-19 pandemic has led to significant re-organisation of healthcare delivery in hospitals, with repercussions on all professionals working healthcare. We aimed assess the impact mental health care institutions and identify individual environmental factors influencing risk disorders. From 4 June 22 September 2020, a total 4370 responded an online questionnaire evaluating psychological distress, severity post-traumatic stress symptoms, factors, coping strategies. About 57% suffered from...
The COVID-19 pandemic exposed intensive care unit (ICU) healthcare workers (HCWs) to acute stress (e.g. unpredictability, fear, helplessness) and chronic prolonged crisis with recurring waves). While the psychological impact has been documented, few studies explore overlap of these stressors. One year after pandemic's first peak, we aimed assess psychotraumatic burnout among ICU HCW examine relationship between disorders, perceived workplace This study was conducted in 77 ICUs France June...
Cystic fibrosis (CF) is caused by compound heterozygosity or homozygosity of CF transmembrane conductance regulator gene (CFTR) mutations. Phenotypic variability associated with certain mutations makes genetic counselling difficult, notably for R117H, whose disease phenotype varies from asymptomatic to classical CF. The high frequency R117H observed in newborn screening has also introduced diagnostic dilemmas. aim this study was evaluate the penetrance order improve clinical practice.The...
France is located in an area with a medium to high prevalence of multiple sclerosis, where its epidemiology not well known. We estimated the national and regional sclerosis on 31 October 2004 incidence between 2003 based data from main French health insurance system: Caisse Nationale d'Assurance Maladie des Travailleurs Salariés. The Salariés insures 87% population. analysed geographic variations using Bayesian approach. On 2004, 49 417 people were registered out 52 359 912 insured Among...
Faivre L, Collod‐Beroud G, Adès Arbustini E, Child A, Callewaert BL, Loeys B, Binquet C, Gautier Mayer K, Arslan‐Kirchner M, Grasso Beroud Hamroun D, Bonithon‐Kopp Plauchu H, Robinson PN, De Backer J, Coucke P, Francke U, Bouchot O, Wolf JE, Stheneur Hanna N, Detaint Paepe Boileau Jondeau G. The new Ghent criteria for Marfan syndrome: what do they change? diagnosis of syndrome (MFS) is challenging and international have been proposed. 1996 were adopted worldwide, but diagnostic MFS released...
Severe blunt trauma is a leading cause of premature death and handicap. However, the benefit for patient pre-hospital management by emergency physicians remains controversial because it may delay admission to hospital. This study aimed compare impact medical performed SMUR (Service Mobile d'Urgences et de Réanimation) with non-medical provided fire brigades (non-SMUR) on 30-day mortality.The FIRST (French Intensive care Recorded in Trauma) multicenter cohort consecutive patients severe...