A5067769230- Cervical Cancer and HPV Research
- Head and Neck Cancer Studies
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Genital Health and Disease
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Advanced Breast Cancer Therapies
- Lung Cancer Research Studies
- RNA modifications and cancer
- Reproductive tract infections research
- Childhood Cancer Survivors' Quality of Life
- Hepatitis C virus research
- Colorectal and Anal Carcinomas
- Neuroendocrine Tumor Research Advances
- Head and Neck Surgical Oncology
- Global Cancer Incidence and Screening
- Cleft Lip and Palate Research
- Oral Health Pathology and Treatment
- HIV/AIDS oral health manifestations
- Neutropenia and Cancer Infections
- NF-κB Signaling Pathways
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Adolescent Sexual and Reproductive Health
Albert Einstein College of Medicine
2016-2025
Roswell Park Comprehensive Cancer Center
2017-2025
Memorial University of Newfoundland
2024
Montefiore Medical Center
2013-2024
McGill University
2001-2021
Icahn School of Medicine at Mount Sinai
2021
Northwell Health
2016
University of Vermont
2016
Fred Hutch Cancer Center
2016
University of Iowa
2016
ContextHuman papillomavirus (HPV) infection is believed to be the central cause of cervical cancer, although most epidemiological evidence has come from retrospective, case-control studies, which do not provide information on dynamics cumulative or persistent exposure HPV infection.ObjectiveTo assess risks neoplasia related prior infections.Design and SettingLongitudinal study natural history in women residing city São Paulo, Brazil, was conducted between November 1993 March 1997 involved...
Little is known in human immunodeficiency virus (HIV)-positive women about how the combination of plasma HIV RNA level and CD4+ T-cell count associated with natural history papillomavirus (HPV) infection or HPV reactivation--whether it occurs what frequency HIV-positive women.HIV-positive (n = 1848) -negative 514) were assessed at semiannual visits (total person-years 5661) for cervicovaginal polymerase chain reaction assays squamous intraepithelial lesions (SILs) by Pap smear. We studied...
Little is known about the duration of precancerous cervical lesions in relation to human papillomavirus (HPV) infection. We estimated rates progression and regression sojourn times squamous intraepithelial (SILs) according HPV status.We used data from a longitudinal study infection neoplasia São Paulo, Brazil. Cervical specimens were taken 2404 women for Pap cytology polymerase chain reaction-based testing every 4-6 months over period 8 years. actuarial non-actuarial analyses measure time...
Background Half of the patients with head and neck squamous cell carcinoma (HNSCC) can be expected to fail therapy, indicating that more aggressive treatment is warranted for this group. We have developed a novel risk model become basis developing new paradigms. Here we report on performance our in multicenter cohort. Design Eligible from 3 institutions (Montefiore Medical Center, University Manitoba, New York Center) were identified pathology slides their resection specimens reviewed by...
Human papillomaviruses (HPVs) primarily sort into 3 genera: Alphapapillomavirus (α-HPV), predominantly isolated from mucosa, and Betapapillomavirus (β-HPV) Gammapapillomavirus (γ-HPV), skin. HPV types might infect body sites that are different those which they were originally isolated.We investigated the spectrum of type distribution in oral rinse samples 2 populations: 52 human immunodeficiency virus (HIV)-positive men women 317 who provided a sample for genomic DNA prostate cancer study....
Small, noncoding microRNAs (miRNAs) have been shown to be abnormally expressed in every tumor type examined. We used comparisons of global miRNA expression profiles head and neck squamous cell carcinoma (HNSCC) samples adjacent normal tissue rank those miRNAs that were most significantly altered our patient population. Rank Consistency Score analysis revealed miR-375 the lowered levels tumors relative matched nonmalignant from same among 736 evaluated. This result has previously observed by...
Some studies suggest that periodontal diseases increase the risk of oral cancer, but contradictory results also exist. Inadequate control confounders, including life course exposures, may have influenced prior findings. We estimate extent to which high levels diseases, measured by gingival inflammation and recession, are associated with cancer using a comprehensive subset potential confounders applying stringent adjustment approach. In hospital‐based case‐control study, incident cases ( N =...
While its prognostic significance remains unclear, p16 INK4a protein expression is increasingly being used as a surrogate marker for oncogenic human papillomavirus (HPV) infection in head and neck squamous cell carcinomas (HNSCC). To evaluate the utility of HNSCC, we prospectively collected 163 primary tumor specimens from histologically confirmed HNSCC patients who were followed up to 9.4 years. Formalin fixed tested by immunohistochemistry (IHC). HPV type‐16 DNA RNA was detected...
Delay in time to treatment initiation (TTI) can alter survival and oncologic outcomes. There is a need characterize these consequences identify risk factors reasons for delay, particularly underserved urban populations.To investigate the association of delayed with outcomes overall recurrence among patients head neck squamous cell carcinoma (HNSCC), analyze that are predictive initiation, specific initiation.Retrospective cohort study at an community-based academic center. Participants were...
The authors investigated the joint effects of tobacco and alcohol consumption on risk squamous cell carcinomas upper aero-digestive tract (UADT) using data from a hospital-based case-control study conducted in southern Brazil, 1986-1989. A total 784 cases cancers mouth, pharynx, larynx 1,578 non-cancer controls matched age, sex, hospital catchment area, period admission were interviewed about their smoking drinking habits other characteristics. Using logistic regression, evidence was found...
Abstract HPV infections are believed to be a necessary cause of cervical cancer. Viral burden, as surrogate indicator for persistence, may help predict risk subsequent SIL. We used results test and cytology data repeated every 4–6 months in 2,081 women participating longitudinal study the natural history infection neoplasia São Paulo, Brazil. Using MY09/11 PCR protocol, 473 were positive DNA during first 2 visits. retested all specimens by quantitative, low‐stringency method measure viral...
Tobacco smoking has long been identified as the most important risk factor for upper aero-digestive tract cancers. To investigate effect of different tobacco types and benefit cessation, we analyzed data from a case-control study 784 cases mouth, pharynx, larynx cancers 1,578 non-cancer controls in three metropolitan hospital areas Brazil. Subjects were interviewed to their drinking habits, demographics, environmental exposures, occupational history, health characteristics, diet. Controlling...
Abstract Epidemiological and laboratory evidence indicate that, in addition to tobacco alcohol, human papillomaviruses (HPV) play an important aetiological role a subset of head neck squamous cell carcinoma (HNSCC). To evaluate the molecular pathogenesis HPV‐infected HNSCC, we compared gene expression patterns between HPV‐positive ‐negative HNSCC tumours using cDNA microarrays. Tumour tissue was collected from 42 histologically confirmed patients inner‐city area New York. Total DNA RNA were...
We have used a genome-wide approach to identify novel differentially methylated CpG dinucleotides that are seen in different anatomic sites of head and neck squamous cell carcinoma (HNSCC), as well those might be related HPV status the oropharynx.We conducted DNA methylation profiling primary tumor samples corresponding adjacent mucosa from 118 HNSCC patients undergoing treatment at Montefiore Medical Center, Bronx, NY, using Illumina HumanMethylation27 beadchip. For each matched tissue set,...
Human papillomavirus type 16 (HPV16)-E6 antibodies are detectable in peripheral blood before diagnosis the majority of HPV16-driven oropharyngeal squamous cell carcinoma (OPSCC), but timing seroconversion is unknown.
Tobacco and alcohol consumption are the main risk factors for head neck squamous cell carcinoma (HNSCC). In addition, human papillomavirus (HPV) infection plays a causal role in oropharyngeal cancer (OPC), subset of HNSCC. We assessed independent effects tobacco, HPV on OPC (HeNCe) Life study, hospital-based case-control study HNSCC with frequency-matched controls by age sex from four Montreal hospitals. Interviewers collected information socio-demographic behavioural factors. tested...
Abstract Background Body mass index (BMI), sarcopenia, and obesity‐related comorbidities have been associated with head neck squamous cell carcinoma (HNSCC) progression. Methods We conducted a retrospective analysis of 441 normal‐weight, overweight, obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment assessed for differences in survival adjusting comorbid conditions (cardiovascular disease diabetes). Evidence sarcopenia was...
Bacterial vaginosis (BV) is a highly prevalent condition that associated with adverse health outcomes. It has been proposed BV's role as pathogenic mediated via bacteria-induced inflammation. However, the complex interplay between vaginal microbes and host immune factors yet to be clearly elucidated. Here, we develop molBV, 16 S rRNA gene amplicon-based classification pipeline generates molecular score diagnoses BV same accuracy current gold standard method (i.e., Nugent score). Using 3...
PURPOSE Seropositivity for the HPV16-E6 oncoprotein is a promising marker early detection of oropharyngeal cancer (OPC), but absolute risk OPC after positive or negative test unknown. METHODS We constructed an prediction model that integrates (1) relative odds serostatus and cigarette smoking from human papillomavirus (HPV) Cancer Cohort Consortium (HPVC3), (2) US population factor data National Health Interview Survey, (3) sex-specific rates mortality. RESULTS The nine HPVC3 cohorts...