A5071247615- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Dental Implant Techniques and Outcomes
- Head and Neck Surgical Oncology
- Periodontal Regeneration and Treatments
- Salivary Gland Disorders and Functions
- Sarcoma Diagnosis and Treatment
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Soft tissue tumor case studies
- Oral and gingival health research
- Dental Radiography and Imaging
- Ear and Head Tumors
- Metastasis and carcinoma case studies
- Wound Healing and Treatments
- dental development and anomalies
- Mesenchymal stem cell research
- Oral health in cancer treatment
- Cancer and Skin Lesions
Tel Aviv University
2015-2024
Sheba Medical Center
2014-2024
Tel Aviv Sourasky Medical Center
2023
University of Oulu
2014-2017
Rabin Medical Center
2009-2017
Oulu University Hospital
2014
University of Sheffield
2013
Taipei Institute of Pathology
2009-2010
ExoQuick-TC TM (EQ), a chemical-based agent designed to precipitate exosomes, was calibrated for use on saliva collected from healthy individuals. The morphological and molecular features of the precipitations were compared with those obtained using classical, physical-based method ultracentrifugation (UC). Electron microscopy immunoelectron anti-CD63 showed vesicular nanoparticles surrounded by bi-layered membrane, compatible exosomes in EQ, similar that observed UC. Atomic force...
We examined cancer-associated fibroblasts (CAFs) and a panel of immunohistochemical markers epithelial-mesenchymal transition (EMT) in 19 pair-matched oral tongue squamous cell carcinoma (SCC) metastatic tumors to regional lymph nodes (RLNs). alpha-Smooth muscle actin (alpha-SMA) was studied identify CAFs. EMT with syndecan-1, Cadherin-11, fibroblast-specific protein (FSP)-1, secreted acidic rich cysteine (SPARC) Twist. Triple immunostaining RLNs used highlight the cells (E-cadherin Ki-67)...
Background: Granular cell tumor (GCT) is a benign lesion that occurs at different body sites with preponderance to the oral cavity. It generally believed be of schwann cell/neural origin. We used large panel both traditional and recently developed antibodies in an attempt trace origin GCTs on basis their immunoprofile. Methods: The patients’ demographic data cytological architectural features lesions were analyzed series ( n = 68). Forty‐two also submitted immunohistochemical stains against...
The gingiva reacts to chronic irritation or trauma with localized reactive hyperplastic lesions (LRHL) that can be classified into four groups: focal fibrous hyperplasia (FFH), pyogenic granuloma (PG), peripheral ossifying fibroma (POF), and giant cell (PGCG). This study determined the frequency of LRHL in an oral pathology biopsy service compared these data reports from other countries.The material included biopsies all consecutive stored departmental database (1989-2008). Lesions were...
Margin status, a major prognostic parameter in oral cancer, was analyzed vis‐à‐vis the histopathologic parameters of risk scores and stromal myofibroblasts. Specimens tongue carcinoma ( n = 50) were submitted to score assignment consisting worst pattern invasion, lymphocytic infiltration, perineural invasion. Frequency myofibroblasts (alpha‐smooth muscle actin stain) assessed. A triple immunostaining assay with E‐cadherin, Ki‐67 alpha‐smooth used identify cells undergoing...
Abstract Background Epidermal growth factor (EGF) and its receptor (EGFR) are involved in the development of salivary gland tumors. Recently, treatment modalities for EGFR inhibition have shown an enhanced clinical response carcinomas different locations. Adenoid cystic carcinoma (ACC) origin is a malignant tumor with poor long‐term outcome. If ACC does exhibit EGFR, then immunotherapy could major impact on improving prognosis. Methods The study consisted 34 samples formalin‐fixed,...
The aggressive biological behavior of odontogenic keratocysts (OKCs), unlike that other cysts, has argued for its recent re-classification as a neoplasm, 'keratocystic tumor'. Identification mutations in the PTCH gene some OKCs were expected to produce truncated proteins, resulting loss control cell cycle, provided additional support having neoplastic nature.We investigated immunohistochemical expression sonic hedgehog (SHH) signaling pathway-related PTCH, smoothened (SMO) and GLI-1,...
Abstract We characterized tumor microenvironment ( TME ) components of mobile tongue MT cancer patients in terms overall inflammatory infiltrate, focusing on the protumorigenic/anti‐inflammatory phenotypes and cancer‐associated fibroblasts CAF s) order to determine their interrelations associations with clinical outcomes. In addition, by culturing carcinoma cells HSC ‐3) a three‐dimensional myoma organotypic model that mimics , we attempted investigate possible existence molecular crosstalk...
Ameloblastoma is a neoplasm arising in the craniofacial skeleton. Proliferating odontogenic epithelial cells comprise this benign, yet locally invasive tumor, often causing severe disfiguration. High recurrence rate entails ablative surgical resection, which current standard of care, resulting subsequent critical size osteocutaneous defects. The high incidence BRAF mutations ameloblastoma, most notably V600E mutation, enabled use inhibiting agent neoadjuvant setting. In...
Abstract Background Ameloblastoma is a rare odontogenic neoplasm frequently located in the mandible. Standard treatment involves radical bone resection and immediate reconstruction, causing functional, aesthetic, psychological impairments. The BRAF V600E mutation present approximately 80% of mandible ameloblastomas, inhibitors have demonstrated sustained responses unresectable cases. Methods We identified ameloblastoma patients planned for ablative surgery screened them mutation. Neoadjuvant...