A5066757523- Head and Neck Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Surgical Oncology
- Tracheal and airway disorders
- Reconstructive Facial Surgery Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Dysphagia Assessment and Management
- Cancer Diagnosis and Treatment
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Oral health in cancer treatment
- Molecular spectroscopy and chirality
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Airway Management and Intubation Techniques
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Nerve Injury and Rehabilitation
- Facial Nerve Paralysis Treatment and Research
- Nonmelanoma Skin Cancer Studies
- Nutrition and Health in Aging
- Peptidase Inhibition and Analysis
- Photodynamic Therapy Research Studies
- Voice and Speech Disorders
University of Alabama at Birmingham
2015-2024
Tennessee Technological University
2015-2023
University of Alabama
1998-2022
Louisiana State University Health Sciences Center New Orleans
2019
Stanford University
2016
St. Vincent's Birmingham
1999-2015
American College of Surgeons
2014
University of South Carolina
2008-2014
California Institute of Technology
2012-2014
Creative Commons
2012
Abstract Two high molecular weight derivatives of fibrinogen (Fragments X and Y) produced by plasmin digestion have been identified comparative analyses the digests in agar, agarose, acrylamide electrophoresis, immunoelectrophoresis, Sephadex G-200 gel filtration, analytical ultracentrifugation. These fragments were purified salt precipitation filtration their physicochemical immunological properties defined. Fragment has a 240,000, as compared with 300,000 for fibrinogen, is slowly but...
Abstract Objectives/Hypothesis: Our objective was to determine the safety, feasibility, and adequacy of surgical margins for transoral robotic surgery (TORS), by reviewing early results from independent institutional review board‐approved clinical trials in three separate institutions. Study Design: Pooled Data Independent Prospective Clinical Trials. Methods: One hundred ninety‐two patients were initially screened, but inadequate exposure did not permit TORS 13 (6.7%). For two additional...
This article was a progress report on Anfinsen's effort to investigate the fine and gross structures of bovine pancreatic ribonuclease, particularly N C terminal sequences nature cross-linkages in RNase. In it, Anfinsen, Redfield, Choate, Page, Carroll described structure indicated that should soon be apparent.
Positive margins dominate clinical outcomes after surgical resections in most solid cancer types, including head and neck squamous cell carcinoma. Unfortunately, surgeons remove the same manner they have for a century with complete dependence on subjective tissue changes to identify operating room. To effect change, we hypothesize that EGFR can be targeted safe specific real-time localization of cancer.A dose escalation study cetuximab conjugated IRDye800 was performed patients (n = 12)...
PURPOSE: To evaluate the diagnostic accuracy of positron emission tomography (PET) with administration 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) relative to that magnetic resonance (MR) imaging and/or computed (CT) in recurrent head and neck cancers. MATERIALS AND METHODS: Twelve adult patients (mean age, 63 years) previously treated cancers clinical suspicion recurrence underwent FDG PET MR CT. All images were blindly independently interpreted without histopathologic findings (obtained...
Abstract Objectives/Hypothesis: Swallowing dysfunction is a devastating complication of chemoradiation therapy (CRT) for head and neck squamous cell carcinoma. We have previously demonstrated that pretreatment swallowing exercises improve posttreatment swallowing‐related quality life. This study evaluates the effect on swallow function as measured by videofluoroscopy. Study Design: Retrospective case control. Methods: Eighteen patients with advanced carcinoma oropharynx, hypopharynx, larynx...
Dysphagia is commonly associated with head and neck cancer treatment. Traditional dysphagia management strategies focus on post-treatment therapy. This study evaluated the utility of pretreatment swallowing exercises in improving quality life (QOL).Prospective cohort cross-sectional QOL analysis.This includes 37 patients who underwent primary radiation or combined chemoradiation treatment for newly diagnosed hypopharyngeal, laryngeal, oropharyngeal tumors at University Alabama Birmingham. Of...
To evaluate functional outcomes following transoral robotic surgery for head and neck cancer.Case series with planned data collection.Academic hospital.Between March 2007 December 2008, 54 of 62 candidate patients underwent tumor resection. Outcomes include airway management, swallowing (MD Anderson Dysphagia Inventory), enterogastric feeding.Tumors were most commonly oropharynx (61%) or larynx (22%) T1 (35%) T2 (44%). Many received radiotherapy (22% preoperatively, 41% postoperatively)...
The preservation of speech and swallowing function is the primary goal when reconstructing soft tissue defects in oral cavity or oropharynx. type reconstructive procedure used should be based on outcome data examining function; yet, there a paucity such information.To present results multi-institutional prospective study before after reconstruction oropharynx, to compare 3 methods with respect function: closure, distal myocutaneous flap, microvascular free flap.Prospective case-comparison...
IMPORTANCE Surgical salvage may be the only viable treatment option for recurrent tumors of oropharynx.To our knowledge, there have been no published reports directly comparing oncologic and functional outcomes patients with oropharyngeal squamous cell carcinoma (SCC) treated transoral robotic-assisted surgery (TORS) those traditional open surgical approaches.OBJECTIVE To compare SCC TORS approaches.
Abstract The nature of the energy source for a representative nonfermenting Mycoplasma, Mycoplasma hominis type II, strain 07, has been studied. results indicate that this microorganism can obtain from metabolism arginine by dihydrolase pathway. conversion to ornithine, with concomitant formation an equimolar amount adenosine triphosphate, is quantitatively sufficient account estimated required synthesis macromolecules in growing cells. Thus may be major energy, but they cannot rule out...
<h3>Objectives</h3> To assess the feasibility and safety of performing robot-assisted resections head neck tumors, to predict which variables lead successful resection better functional outcome. <h3>Design</h3> Prospective nonrandomized clinical trial. <h3>Setting</h3> Academic tertiary referral center. <h3>Patients</h3> Thirty-six patients with oral cavity, oropharyngeal, hypopharyngeal, or laryngeal tumors. <h3>Intervention</h3> Robot-assisted indicated <h3>Main Outcome Measures</h3>...
<h3>Objective</h3>To evaluate changes in patient-perceived swallowing function over time following transoral robotic surgery (TORS) for primary T1 and T2 oropharyngeal squamous cell carcinomas.<h3>Design</h3>Prospective case series.<h3>Setting</h3>Academic tertiary referral center.<h3>Patients</h3>Forty-two patients with or carcinomas.<h3>Intervention</h3>TORS-assisted resection of indicated tumors.<h3>Main Outcome Measures</h3>Changes (using the M. D. Anderson Dysphagia Inventory)...
Objectives/Hypothesis Define surgical outcomes of specific donor sites for free tissue transfer in head and neck reconstruction. Study Design Retrospective cohort review at an academic tertiary care center. Methods A was made procedures performed a university‐based facility from October 2004 to April 2011. total 1,051 patients underwent six types flaps: fasciocutaneous radial forearm (53%), osteocutaneous (16%), rectus abdominis (11%), fibula (10%), anterior lateral thigh (7%), latissimus...
Abstract Purpose: Comprehensive cervical lymphadenectomy can be associated with significant morbidity and poor quality of life. This study evaluated the sensitivity specificity cetuximab-IRDye800CW to identify metastatic disease in patients head neck cancer. Experimental Design: Consenting scheduled for curative resection were enrolled a clinical trial evaluate safety cetuximab-IRDye800CW. Patients (n = 12) received escalating doses drug. Where indicated, accompanied primary tumor resection,...
[99mTc]Tilmanocept, a novel CD206 receptor-targeted radiopharmaceutical, was evaluated in an open-label, phase III trial to determine the false negative rate (FNR) of sentinel lymph node biopsy (SLNB) relative pathologic nodal status patients with intraoral or cutaneous head and neck squamous cell carcinoma (HNSCC) undergoing tumor resection, SLNB, planned elective dissection (END). Negative predictive value (NPV), overall accuracy impact radiopharmaceutical injection timing surgery were...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Specific Ion Effects on the Conformation and Thermal Stability of Ribonuclease*Ann Ginsburg William R. CarrollCite this: Biochemistry 1965, 4, 10, 2159–2174Publication Date (Print):October 1, 1965Publication History Published online1 May 2002Published inissue 1 October 1965https://pubs.acs.org/doi/10.1021/bi00886a033https://doi.org/10.1021/bi00886a033research-articleACS PublicationsRequest reuse permissionsArticle...