[99mTc]Tilmanocept, a novel CD206 receptor-targeted radiopharmaceutical, was evaluated in an open-label, phase III trial to determine the false negative rate (FNR) of sentinel lymph node biopsy (SLNB) relative pathologic nodal status patients with intraoral or cutaneous head and neck squamous cell carcinoma (HNSCC) undergoing tumor resection, SLNB, planned elective dissection (END). Negative predictive value (NPV), overall accuracy impact radiopharmaceutical injection timing surgery were...

While the role of gut microbiome in inflammation and colorectal cancers has received much recent attention, there are few data to support an association between oral head neck squamous cell carcinomas. Prior investigations have been limited comparisons microbiota obtained from surface swabs cavity. This study aims identify microbiomic differences paired tumor non-tumor tissue samples a large group 121 patients with carcinomas correlate these clinical-pathologic features. Total DNA was...

OBJECTIVE Describe frontal sinus pneumatization in patients with no history of disease. STUDY DESIGN AND METHODS All 1‐mm axial CT scans performed from 2001 through 2003 were eligible for review on a CBYON Suite workstation (CBYON, Mountain View, CA). Exclusion criteria included sinusitis, sinonasal polyposis, age < 18 years, malignancy, fibroosseous lesions, maxillofacial trauma, congenital anomaly, and surgery. RESULTS A total 50 met the inclusion criteria. The prevalence each structure...

Abstract Background Concurrent chemoradiation therapy has been demonstrated to be effective as an organ‐sparing treatment for select advanced head and neck squamous cell carcinoma (HNSCC). However, this modality is not without side effects. One effect the formation of upper esophageal strictures. As concurrent used more frequently, it important identify risk factors associated with stricture formation. Methods A retrospective chart review all patients who had undergone definitive between...

No AccessJournal of UrologyAdult Urology1 Jan 2013Reproductive Potential Men with Obstructive Azoospermia Undergoing Percutaneous Sperm Retrieval and Intracytoplasmic Injection According to the Cause Obstruction Sandro C. Esteves, Walter Lee, David J. Benjamin, Bill Seol, Sidney Verza, Ashok Agarwal EstevesSandro Esteves Androfert, Center for Male Reproduction, Campinas, Brazil , LeeWalter Lee Reproductive Medicine, Cleveland Clinic Foundation, Cleveland, Ohio BenjaminDavid Benjamin SeolBill...

Objectives: One treatment option for unilateral vocal fold paralysis (UVFP) is ansa cervicalis-to-recurrent laryngeal nerve (ansa-RLN) anastomosis to provide reinnervation the affected fold. The advantages of this approach are that it 1) provides tone, bulk, and tension, 2) technically simple, 3) does not preclude other medialization procedures. We present all patients who have undergone ansa-RLN UVFP at our institution. Methods: An Institutional Review Board-approved retrospective chart...

We sought to describe the results of ansa cervicalis recurrent laryngeal nerve (ansa-RLN) reinnervation for unilateral vocal fold paralysis.A chart review was performed on patients undergoing ansa-RLN cord paralysis at a tertiary care center. Patient perceptions preoperative and postoperative voice quality surveyed. Acoustic visual parameters were assessed from videostroboscopy.From total 25 study patients, 15 underwent both postoperativ video stroboscopies. In stroboscopies within 6 months,...

Patients with head and neck cancer (HNC) are known to be at increased risk of suicide compared the general population, but there has been insufficient research on whether this differs based patients' rural, urban, or metropolitan residence status.

Laryngotracheal trauma may result in lifelong complications or even death if diagnosis treatment is delayed. Emergency room physicians, surgeons, anesthesiologists, and especially otolaryngologists should maintain a high level of awareness suspicion for laryngotracheal whenever patient presents with multiple general cervical particular. Although there some controversy regarding care, experienced hands will usually favorable outcome. In this article, we review update the management acute...

Minimal requirements for generating effective immunity include the delivery of antigenic (signal 1) and costimulatory 2) signals to T lymphocytes. Recently, a class third signals, often delivered by antigen-presenting dendritic cells, has been shown greatly enhance immune responses, especially against tumors. Among signal 3 factors, interleukin (IL)-12 is particularly can be conditionally induced agonists Toll-like transmembrane receptors (TLR). In this study, we assessed therapeutic effect...

High rates of local recurrence in tobacco-related head and neck squamous cell carcinoma (HNSCC) are commonly attributed to unresected fields precancerous tissue. Because they not easily detectable at the time surgery without additional biopsies, there is a need for noninvasive methods predict extent dynamics these fields. Here, we developed spatial stochastic model HNSCC tissue level calibrated using Bayesian framework population-level incidence data from Surveillance, Epidemiology, End...

Dendritic cells (DCs) loaded with antigens can effectively stimulate host immune responses to syngeneic tumors, but there is considerable controversy as which forms of antigen-loading are most immunogenic. Here, the authors compared immunotherapeutic reactivities DCs a variety antigen preparations. Because DC maturation stages affect their capacities processing and presentation, two populations were used for current analysis: in vivo Flt-3 ligand-induced mature vitro bone marrow-derived DCs,...

<h3>Objective</h3> To determine the incidence and character of clinically significant laryngotracheal anomalies in pediatric patients undergoing surgical repair congenital cardiac defects at a tertiary care center. <h3>Design</h3> Single-center retrospective review. <h3>Patients</h3> The charts who required treatment for heart disease over 4-year period were reviewed. Forty-eight 1957 seen inpatient consultation by otolaryngology service. parameters studied included diagnosis, reason...

To evaluate the prevalence of specific frontal recess cells in Korean and Caucasian populations; to compare relationship between anterior skull base length pneumatization these two populations.Frontal anatomy was studied with high resolution sinus CT scans obtained 60 adults 41 adults. None subjects had a history disease or trauma. The cranial (ACBL, distance nasion center pituitary fossa) ethmoid (AEL, upper attachment basal lamella) also measured on each side.Supraorbital were more common...

Abstract Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with more than half a million people being diagnosed the disease annually. Within last 2 decades, human papillomavirus (HPV) has been found to be associated this malignancy. More recently, HPV‐infected HNSCC exhibit higher levels of global DNA methylation. In recent study, we identified five tumor suppressive genes ( IRX1 , EBF3 SLC5A8 SEPT9 FUSSEL18 ) as frequently methylated in biopsies using methylation...

Objective. To describe the usefulness of intraoperative frozen section in diagnosis and treatment thyroid nodules where fine needle aspirate biopsies have evidence follicular neoplasm. Study Design. Retrospective case series. Methods. All patients a biopsy, an section, final pathology performed on nodule after initiation Bethesda System for Reporting Thyroid Cytopathology 2009 at single tertiary referral center. Sensitivity, specificity, positive predictive value, negative value are...

Objectives/Hypothesis To compare long‐term symptomatic outcomes between external transcervical (ET) and endoscopic stapling diverticulotomy (ESD) surgeries for Zenker's diverticulum. Study Design Retrospective review. Methods Patients undergoing surgery diverticulum 1998 2010 with at least 1 year follow‐up were telephoned questioned dysphagia, choking, regurgitation, halitosis based on a validated Gastrointestinal Quality‐of‐Life Index. Symptom degree preoperatively phone call was assessed....

<h3>Objective</h3> To describe a quantitative analysis of the lateral lamella cribriform plate (LLCP) height in computed tomographic (CT) images. The LLCP is thinnest anatomic structure skull base. <h3>Design</h3> Software-enabled CT scan measurements. <h3>Setting</h3> Academic center. <h3>Results</h3> scans from 50 patients were analyzed. median 100 sides was 2.4 mm. 0 to 3.9 mm 83 sides, 4.0 7.0 15 and greater than 2 sides. When analyzing differences among on right side 28 left 22. between...

To assess whether patient age or sex was predictive of a bilaterally absent cervical ocular vestibular evoked myogenic potential (cVEMP oVEMP).Retrospective case review.Tertiary center.Patients presenting with normal tests (i.e. caloric and rotational chair) who underwent cVEMP and/or oVEMP testing. Patients conductive hearing loss were excluded as those unilaterally abnormal VEMP results because they presented evidence possible unilateral impairment. A total 895 patients met criteria for...

<h3>Objectives</h3>To evaluate the criteria used by otolaryngology programs in ranking residency candidates and to compare candidate among applicant expectations.<h3>Design</h3>Cross-sectional, anonymous survey administered during 2009 2010 match cycles.<h3>Setting</h3>Otolaryngology programs.<h3>Participants</h3>Otolaryngology program applicants (PAs) directors (PDs).<h3>Main Outcome Measures</h3>The PDs were asked rank importance of 10 choosing a on 20-point scale (with 1 indicating utmost...

A promising cancer vaccine involves the fusion of tumor cells with dendritic (DCs). As such, a broad spectrum both known and unidentified antigens is presented to immune system in context potent immunostimulatory capacity DCs. Murine studies have demonstrated efficacy immunotherapy. However clinical impact DC/tumor vaccines has been limited, suggesting that immunosuppresive milieu found patients malignancies may blunt vaccination. Thus, novel strategies enhance are needed. Regulatory T...

IntroductionSurgical Training and Education in Promoting Professionalism (STEPP) was developed 2011 to train tomorrow's leaders during residency. It is based on virtue ethics takes an approach similar West Point military academy. The purpose of this research was: (i) compare the profiles our residents with that cohort using a standardized assessment tool; (ii) assess value education residents.MethodsAs part STEPP, otolaryngology participated virtue-based validated tool called Virtue Action...