A5018130061- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Hernia repair and management
- Gastric Cancer Management and Outcomes
- Urinary Tract Infections Management
- Neuroendocrine Tumor Research Advances
- Cardiac Arrest and Resuscitation
- Colorectal Cancer Screening and Detection
- Dialysis and Renal Disease Management
- Metastasis and carcinoma case studies
- Hemodynamic Monitoring and Therapy
- Anorectal Disease Treatments and Outcomes
- Dementia and Cognitive Impairment Research
- Antimicrobial Resistance in Staphylococcus
- Esophageal Cancer Research and Treatment
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal and GI Pathology
- Pelvic and Acetabular Injuries
- Pancreatic and Hepatic Oncology Research
- Microscopic Colitis
- Lung Cancer Research Studies
- Chemical Thermodynamics and Molecular Structure
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
Cleveland Clinic
2016-2025
Cleveland Clinic Lerner College of Medicine
2007-2023
EBSCO Industries (United States)
2023
Northumbria Healthcare NHS Foundation Trust
2020
University Hospitals of North Midlands NHS Trust
2019
University of Minnesota
2019
Louis Stokes Cleveland VA Medical Center
2016
Quantitative BioSciences
2009-2011
Pennsylvania State University
1977-2006
Cancer Research And Biostatistics
2006
The acknowledgement of risks for traumatic brain injury in American football players has prompted studies sideline concussion diagnosis and testing neurological deficits. While concussions are recognized etiological factors a spectrum sequelae, the consequences sub-concussive events unclear. We tested hypothesis that blood-brain barrier disruption (BBBD) accompanying surge astrocytic protein S100B blood may cause an immune response associated with production auto-antibodies. also wished to...
Abstract Based on the accumulating evidence of osteogenic cells present in systemic circulation, we hypothesized that circulating connective tissue progenitors (CTPs) home to fracture site and contribute skeletal repair. Parabiotic animals were formed by surgically conjoining transgenic mice constitutively expressing green fluorescent protein (GFP) no erythroid syngeneic wild‐type mice. After 3 weeks parabionts, equilibrium blood chimerism between partners was established. A transverse...
Abstract Background Concurrent chemoradiation therapy has been demonstrated to be effective as an organ‐sparing treatment for select advanced head and neck squamous cell carcinoma (HNSCC). However, this modality is not without side effects. One effect the formation of upper esophageal strictures. As concurrent used more frequently, it important identify risk factors associated with stricture formation. Methods A retrospective chart review all patients who had undergone definitive between...
The objective of this study was to determine whether meditation affects pain and quality life in people with multiple sclerosis (MS) peripheral neuropathy (PN). A total 22 patients (10 MS, 12 PN) participated a weekly class over 2-month period. 18 controls (7 11 received standard care. Primary outcome assessments were based on the 36-item Short Form Health Status Survey (SF-36) visual analogue scale (VAS) for at baseline 2 months. Secondary measures included Neuropathy Impairment Score (NIS)...
Vasopressin is often utilized for hemodynamic support in patients with septic shock. However, the most appropriate patient to initiate therapy unknown. This study was conducted determine factors associated response fixed-dose vasopressin shock.Single-center, retrospective cohort of receiving shock at least 6 h concomitant catecholamines medical, surgical, or neurosciences intensive care unit (ICU) a tertiary center. Patients were classified as responders non-responders vasopressin. Response...
ObjectivesThe need for indwelling vascular access outpatient parenteral antimicrobial therapy (OPAT) places patients at risk of complications. The purpose this study was to describe complications during OPAT home, and identify factors associated with their occurrence.
INTRODUCTION: To estimate the annual incidence of hepatocellular carcinoma (HCC) in patients with nonalcoholic steatohepatitis (NASH) advanced liver fibrosis, to determine risk factors for development HCC, and evaluate chemoprotective effect statin use stratified by fibrosis stage. METHODS: We conducted a retrospective study at 2 US tertiary academic centers, including NASH-related (bridging [F3] cirrhosis [F4]) followed between July 2002 June 2016. Patients were from date diagnosis time...
Background: The bony architecture of the hip depends upon functional adaptation to mechanical usage via dynamic interaction between acetabulum and femoral head. Acetabular retroversion is thought be a contributing factor pincer-type femoroacetabular impingement. Studies pathological joints suggest proximal anatomy compensates for acetabular retroversion. Hypothesis/Purpose: purpose this study was determine if predictable relationship exists angles, age, gender in normal joints. We...
Trauma is the leading cause of death for people ages 1-44, with blood loss comprising 60-70% mortality in absence lethal CNS or cardiac injury. Immediate intervention critical to improving chances survival. While there are several products control bleeding external and compressible wounds, including pressure dressings, tourniquets, topical materials (e.g., QuikClot, HemCon), no that can be administered field internal bleeding. There a tremendous unmet need hemostatic agent address field. We...
To compare the biological effects of riboflavin-ultraviolet A (UVA) corneal cross-linking (CXL) performed with a traditional epithelium-off method to several transepithelial methods in rabbit model. Preliminary experiments on biomechanical rigidity were also performed.Four treatment groups included: (1) standard epithelium-off, (2) tetracaine transepithelial, (3) benzal-konium chloride-ethylenediaminetetraacetic acid (BKC-EDTA) and (4) femtosecond laser-assisted riboflavin-UVA CXL. Six eyes...
No AccessJournal of UrologyNew Technology and Techniques1 Jul 2023First in Human Subjects Testing the UroMonitor: A Catheter-free Wireless Ambulatory Bladder Pressure MonitorThis article is commented on by following:Editorial Comment Brendan T. Frainey, Steve J. A. Majerus, Samir Derisavifard, Kevin C. Lewis, Anna R. Williams, Brian M. Balog, Robert S. Butler, Howard B. Goldman, Margot Damaser FraineyBrendan Frainey Glickman Urological Kidney Institute, Cleveland Clinic, Cleveland, Ohio ,...
Polyneuropathy evaluation in older patients is often challenging due to conflicting data regarding normative values for peripheral nerve testing.We characterized the results of sural conduction studies, intraepidermal fiber density (IENFD), and quantitative sudomotor axon reflex testing (QSART) a prospective study 50 healthy subjects aged ≥60 years.Of subjects, 48 (96%) had an obtainable sensory action potential (SNAP). Using quantile regression, we estimated lower limit normal (LLN)...
We investigated the contribution of bronchial blood flow to lung lymph (QL) and edema formation after inhalation injury in sheep (n = 18). The animals were equally divided into three groups chronically prepared by implantation cardiopulmonary catheters a probe on common artery. Groups 1 2 insufflated with 48 breaths cotton smoke while group 3 received only room air. Just before injury, artery was occluded. occlusion maintained for duration 24-h study period. At end investigation, samples...
A dual childbirth injury model, including vaginal distension (VD) and pudendal nerve crush (PNC), may best represent the injuries seen clinically. The objective of this study was to investigate urethral function, anatomy, neurotrophin expression after several simulated injuries. Groups 140 rats underwent PNC, VD, PNC+VD, or neither (C). Four days injury, all groups had significantly decreased leak-point pressure (LPP) compared with C rats. Ten LPP in PNC PNC+VD remained lower than Three...
We investigated the effect of duration vaginal distention on differential expression stem cell homing, tissue repair cytokines and cytokine receptors to identify factors most important for recovery from injury.A total 20, 10-week-old virgin Sprague-Dawley rats were divided into 4 groups, including 1, 6-hour distention, anesthetized sham operation. The vagina, bladder, urethra rectum harvested immediately after distention. Real-time polymerase chain reaction was used determine relative...
Colorectal cancer (CRC) is rising in young adults between ages 20 to 49 years. CRC screening endorsed for average-risk individuals beginning at 45 Targeting <45 years may be warranted if risk factors advanced neoplasia can identified.
Early-onset colorectal cancer (CRC) requires identifying adults at heightened risk of advanced neoplasia (AN) who may warrant colonoscopy initiation < age 45 years. We aim to develop and validate a model estimating the likelihood AN in performed cross-sectional analysis adults' ages 18-44 years underwent between 2011 2021 tertiary center. Subjects with constituted case group while those normal or non-advanced (NAN) formed control group. used backward elimination multivariable logistic...