A5083855375- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Tracheal and airway disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Reconstructive Surgery and Microvascular Techniques
- Molecular Biology Techniques and Applications
- Cancer-related gene regulation
- Oral health in cancer treatment
- Immune Cell Function and Interaction
- Dysphagia Assessment and Management
- Brain Metastases and Treatment
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Voice and Speech Disorders
- Cancer Cells and Metastasis
- interferon and immune responses
University of Michigan
2015-2024
Michigan Medicine
2013-2022
Centre Léon Bérard
2021
The University of Texas MD Anderson Cancer Center
2017-2020
Arkansas Department of Agriculture
2020
John Wiley & Sons (United States)
2020
Hudson Institute
2020
University of California, San Francisco
2018-2019
Leibniz Institute for Prevention Research and Epidemiology - BIPS
2019
University of Bremen
2019
We performed a prospective, randomized study in patients with previously untreated advanced (Stage III or IV) laryngeal squamous carcinoma to compare the results of induction chemotherapy followed by definitive radiation therapy those conventional laryngectomy and postoperative radiation.
Like many epithelial tumors, head and neck squamous cell carcinoma (HNSCC) contains a heterogeneous population of cancer cells. We developed an immunodeficient mouse model to test the tumorigenic potential different populations cells derived from primary, unmanipulated human HNSCC samples. show that minority CD44(+) cells, which typically comprise <10% in tumor, but not CD44(-) gave rise new tumors vivo. Immunohistochemistry revealed have primitive cellular morphology costain with basal...
Since the first description of radical neck dissection by George Crile almost a century ago, many variations and modifications procedure have been added. These include functional dissection, modified various selective dissections. In response to need for an organized approach in describing these operations, Committee Head Neck Surgery Oncology American Academy Otolaryngology-Head (AAO-HNS) 1988 initiated effort develop standardized classification system (Table 1). During this process, input...
Purpose To prospectively identify markers of response to therapy and outcome in an organ-sparing trial for advanced oropharyngeal cancer. Patients Methods Pretreatment biopsies were examined expression epidermal growth factor receptor (EGFR), p16, Bcl-xL, p53 as well mutation. These assessed association with high-risk human papillomavirus (HPV), therapy, survival. Patient variables included smoking history, sex, age, primary site, tumor stage, nodal status. Results EGFR was inversely...
<h3>Objective</h3> To identify clinical predictors of quality life (QoL) in a head and neck cancer patient population. <h3>Design, Patients, Setting</h3> A convenience sample 570 patients with upper aerodigestive tract cancers were surveyed at tertiary care oncology clinic Veterans Affairs otolaryngology clinic. <h3>Interventions</h3> self-administered health survey was constructed to collect demographic, health, smoking, alcohol, depression symptom, QoL information. Tumor site tumor stage,...
Abstract Background In accord with the cancer stem cell (CSC) theory, only a small subset of cells are capable forming tumors. We previously reported that CD44 isolates tumorigenic from head and neck squamous (HNSCC). Recent studies indicate aldehyde dehydrogenase (ALDH) activity may represent more specific marker CSCs. Methods Six primary HNSCCs were collected. Cells high low ALDH (ALDH /ALDH ) isolated. populations implanted into NOD/SCID mice monitored for tumor development. Results...
Purpose To test induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CRT) or surgery/radiotherapy (RT) for advanced oropharyngeal cancer and to assess the effect of human papilloma virus (HPV) on response outcome. Patients Methods Sixty-six patients (51 male; 15 female) with stage III IV squamous cell carcinoma oropharynx (SCCOP) were treated one cycle cisplatin (100 mg/m 2 ) carboplatin (AUC 6) fluorouracil (1,000 /d 5 days) select candidates CRT. Those achieving a greater...
Purpose To assess clinical and functional results of chemoradiotherapy for oropharyngeal cancer (OPC), utilizing intensity-modulated radiotherapy (IMRT) to spare the important swallowing structures reduce post-therapy dysphagia. Patients Methods This was a prospective study weekly chemotherapy (carboplatin dosed at one times area under curve [AUC, AUC 1] paclitaxel 30 mg/m 2 ) concurrent with IMRT aiming noninvolved parts structures: pharyngeal constrictors, glottic supraglottic larynx,...
Abstract BACKGROUND. Increased pretreatment serum interleukin (IL)‐6 levels among patients with head and neck squamous cell carcinoma (HNSCC) have been shown to correlate poor prognosis, but sample sizes in prior studies small thus unable control for other known prognostic variables. METHODS. A longitudinal, prospective cohort study determined the correlation between IL‐6 levels, tumor recurrence all‐cause survival a large population (N = 444) of previously untreated HNSCC patients. Control...
Because immune responses within the tumor microenvironment are important predictors of biology, correlations types infiltrating lymphocytes (TILs) with clinical outcomes were determined in 278 patients head and neck squamous cell carcinoma (HNSCC).Infiltrating levels CD4 (helper T cells), CD8 (cytotoxic/suppressor FoxP3 (regulatory CD68 (myeloid-derived suppressor cells,) CD1a (Langerhans) cells measured tissue microarrays (TMAs). Cox models tested associations patient after adjusting for...
The goal of this study was to examine the effect tobacco use on disease recurrence (local/regional recurrence, distant metastasis, or second primary) among patients with human papillomavirus (HPV)-positive squamous cell carcinoma oropharynx (SCCOP) following a complete response chemoradiation therapy.Between 1999 and 2007, 124 advanced SCCOP (86% stage IV) adequate tumor tissue for HPV analysis who were enrolled in one two consecutive University Michigan treatment protocols prospectively...
This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers focuses on glottic laryngeal cancer, which is most common type of cancer has an excellent cure rate. The lymphatic drainage glottis sparse, early stage primaries rarely spread to regional nodes. Because hoarseness symptom, at diagnosis. Updates these guidelines 2014 include revisions "Principles Radiation Therapy" each site Surgery," addition a new section Dental Evaluation Management."
These NCCN Guidelines Insights focus on recent updates to the 2015 for Head and Neck (H&N) Cancers. describe different types of particle therapy that may be used treat H&N cancers, in contrast traditional radiation (RT) with photons (x-ray). Research is ongoing regarding therapy, including protons carbon ions, goals reducing long-term side effects from RT improving therapeutic index. For update, Cancers Panel agreed delete recommendations neutron salivary gland because its limited...
Abstract The incidence of human papillomavirus (HPV)–related oropharynx cancer has steadily increased over the past two decades and now represents a majority oropharyngeal cases. Integration HPV genome into host is common event during carcinogenesis that clinically relevant effects if viral early genes are transcribed. Understanding impact integration on clinical outcomes head neck squamous cell carcinoma (HNSCC) critical for implementing deescalated treatment approaches HPV+ HNSCC patients....
E-cadherin is a transmembrane glycoprotein that mediates calcium-dependent, homotypic cell-cell adhesion and plays an important role in maintaining the normal phenotype of epithelial cells. Disruption activity cells correlates with formation metastatic tumors. Decreased adhesive function may be implemented number ways including: (a) decreased expression E-cadherin; (b) mutations gene encoding or (c) genes encode catenins, proteins link cadherins to cytoskeleton are essential for cadherin...