A5002679236- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Oral and Maxillofacial Pathology
- Tracheal and airway disorders
- Cancer Diagnosis and Treatment
- Tumors and Oncological Cases
- Obstructive Sleep Apnea Research
- Head and Neck Anomalies
- Neuroscience of respiration and sleep
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Reconstructive Surgery and Microvascular Techniques
- Cervical Cancer and HPV Research
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Airway Management and Intubation Techniques
- Vascular Malformations and Hemangiomas
- Bone Tumor Diagnosis and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Facial Nerve Paralysis Treatment and Research
- Pituitary Gland Disorders and Treatments
- Lung Cancer Treatments and Mutations
Johns Hopkins University
2016-2025
Johns Hopkins Medicine
2015-2025
Temple University
2024
Harvard University
2024
American Academy of Otolaryngology — Head and Neck Surgery
2024
Pioneer (United States)
2023
Johns Hopkins Hospital
1998-2022
Sidney Kimmel Comprehensive Cancer Center
2014-2022
National Patient Safety Foundation
2022
Triological Society
2021
Treatment is complex for patients with head and neck (H&N) cancers specific site of disease, stage, pathologic findings guiding treatment decision-making. planning H&N involves a multidisciplinary team experts. This article describes supportive care recommendations in the NCCN Guidelines Head Neck Cancers, as well rationale supporting new section on imaging cancers. also updates to very advanced salivary gland tumors, specifically systemic therapy recommendations.
Abstract Purpose: Oral fluid (saliva) meets the demand for noninvasive, accessible, and highly efficient diagnostic medium. Recent discovery that a large panel of human RNA can be reliably detected in saliva gives rise to novel clinical approach, salivary transcriptome diagnostics. The purpose this study is evaluate value new approach by using oral squamous cell carcinoma (OSCC) as proof-of-principle disease. Experimental Design: Unstimulated was collected from patients (n = 32) with primary...
<section class="abstract"><p id="P1">The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment recommendations cancers of the lip, oral cavity, pharynx, larynx, ethmoid maxillary sinuses, salivary glands. Recommendations are also provided occult primary H&N, separate algorithms have been developed by panel very advanced H&N cancers. These Insights summarize panel's discussion most recent regarding evaluation nasopharyngeal carcinoma. </section>
Tumor DNA in saliva and plasma can provide a noninvasive biomarker for head neck squamous cell carcinoma.
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers provide treatment recommendations cancers of the lip, oral cavity, pharynx, larynx, ethmoid maxillary sinuses, salivary glands. Recommendations are also provided occult primary head neck (H&N), separate algorithms have been developed by panel very advanced H&N cancers. These Insights summarize panel's discussion most recent regarding increase human papillomavirus–associated oropharyngeal cancer...
The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, paranasal sinuses. Occult primary cancer, salivary gland melanoma (MM) are also addressed. specific site of disease, stage, pathologic findings guide treatment (eg, appropriate surgical procedure, radiation targets, dose fractionation radiation, indications systemic therapy). Panel meets at least annually to review comments from reviewers within their...
This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers focuses on glottic laryngeal cancer, which is most common type of cancer has an excellent cure rate. The lymphatic drainage glottis sparse, early stage primaries rarely spread to regional nodes. Because hoarseness symptom, at diagnosis. Updates these guidelines 2014 include revisions "Principles Radiation Therapy" each site Surgery," addition a new section Dental Evaluation Management."
These NCCN Guidelines Insights focus on recent updates to the 2015 for Head and Neck (H&N) Cancers. describe different types of particle therapy that may be used treat H&N cancers, in contrast traditional radiation (RT) with photons (x-ray). Research is ongoing regarding therapy, including protons carbon ions, goals reducing long-term side effects from RT improving therapeutic index. For update, Cancers Panel agreed delete recommendations neutron salivary gland because its limited...
BACKGROUND Human papillomavirus (HPV) is a well‐established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers women and nonwhites in studies to date, sex racial/ethnic differences prognosis have not been well explored. In this study, survival were explored by tumor HPV status among 1) patients with OPSCCs race 2) nonoropharyngeal (non‐OP) head neck cancers (HNSCCs). METHODS This retrospective, multi‐institution study included non‐OP HNSCCs oral...
<h3>Background</h3> Hypoglossal nerve stimulation has been demonstrated to relieve upper airway obstruction acutely, but its effect on obstructive sleep apnea is not known. <h3>Objective</h3> To determine the response in electrical of hypoglossal nerve. <h3>Methods</h3> Eight patients with were implanted a device that stimulated unilaterally during inspiration. Sleep and breathing patterns examined at baseline before implantation after 1, 3, 6 months last follow-up. <h3>Results</h3>...
The influence of lingual muscle activity on airflow dynamics in the upper airway was examined nine patients with obstructive sleep apnea. Muscles that retract tongue (hyoglossus and styloglossus) protrude (genioglossus) were selectively stimulated electrically during fine wire electrodes placed intramuscularly transorally. We confirmed stimulation 50 Hz 40-microseconds pulse duration did not elicit changes electroencephalographic patterns or heart rate alter after burst had ceased. highest...
Abstract Few reports have described in detail the injuries that occur to oral cavity, pharynx, and larynx following caustic ingestion. 1 The role of dynamic radiographic studies delineate extent damage has been minimized. 2 In‐depth analysis such cases not, our knowledge, previously reported. In order examine functional abnormalities these sites ingestion, records Johns Hopkins Swallowing Center were reviewed. Five patients identified as having significant upper aerodigestive tract injuries....
Previous investigators have demonstrated variable responses to uvulopalatopharyngoplasty (UPP) in patients with obstructive sleep apnea. We hypothesized that this variability is due either (1) differences baseline pharyngeal collapsibility preoperatively or (2) magnitude of the decrease resulting from surgery. To determine relationship between changes and response UPP surgery, we measured upper airway critical pressure (Pcrit) before after 13 During non-REM sleep, maximal inspiratory airflow...
Acinic cell carcinoma (ACC) is a low-grade salivary gland malignancy characterized by serous acinar differentiation. Most ACCs arise in the parotid gland, but have been reported to originate nonparotid glands where acini are less abundant. Given recent discovery of mammary analog secretory (MASC)-a that histologically mimics ACC-a retrospective reevaluation warranted. The surgical pathology archives Johns Hopkins Hospital were searched for all arising outside gland. For each case, histologic...
These NCCN Guidelines Insights focus on nutrition and supportive care for patients with head neck cancers. This topic was a recent addition to the Clinical Practice in Oncology (NCCN Guidelines) Head Neck Cancers. The major updates discuss new greater detail. complete version of Cancers is available Web site (NCCN.org).
BACKGROUND The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing among older adults. It unknown whether these trends can be explained by human papillomavirus (HPV) and HPV‐related tumors remain associated with an improved prognosis patients. METHODS In a retrospective study OPSCCs diagnosed from 1995 to 2013 at 2 National Comprehensive Cancer Network–designated cancer centers, p16 immunohistochemistry in situ hybridization (ISH) for HPV‐16, high‐risk DNA, and/or E6/E7...
Human papillomavirus (HPV) causes an increasing proportion of oropharyngeal squamous cell carcinomas (OPSCCs), particularly in white men. The prevalence HPV among other demographic groups and anatomic sites HNSCC is unclear.To explore the role tumor status women nonwhites with OPSCC patients nonoropharyngeal head neck carcinoma (non-OP HNSCC).Retrospective cohort study at 2 tertiary academic centers including cases diagnosed 1995 through 2012, oversampled for minorities females. A stratified...
Human papillomavirus (HPV) tumor status and surgical salvage are associated with improved prognosis for patients recurrent oropharyngeal squamous cell carcinoma (OPSCC). Current data regarding types of surgery the impact distant metastatic disease limited.A retrospective analysis OPSCC from 2 institutions between 2000 2012 was performed. p16 immunohistochemistry and/or in situ hybridization, as clinically available, were used to determine HPV status. Clinical characteristics, distribution...