A5049621619- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Oral and Maxillofacial Pathology
- Salivary Gland Disorders and Functions
- Cytokine Signaling Pathways and Interactions
- Combustion and flame dynamics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Tracheal and airway disorders
- Chronic Lymphocytic Leukemia Research
- Cancer Diagnosis and Treatment
- Tumors and Oncological Cases
- Esophageal Cancer Research and Treatment
- Turbomachinery Performance and Optimization
- Reconstructive Surgery and Microvascular Techniques
- Colorectal and Anal Carcinomas
- Head and Neck Anomalies
- Dysphagia Assessment and Management
- IgG4-Related and Inflammatory Diseases
- Cancer Immunotherapy and Biomarkers
- Meningioma and schwannoma management
- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
University of California, San Francisco
2016-2025
University of Maryland, Baltimore
2024
University of California, San Diego
2023
Pioneer (United States)
2023
Bay Medical Center
2021
University of California, Berkeley
2021
Triological Society
2020
Louisiana State University
2019
University of California San Francisco Medical Center
2017-2018
Medtronic (Ireland)
2016
BACKGROUND Human papillomavirus (HPV) is a well‐established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers women and nonwhites in studies to date, sex racial/ethnic differences prognosis have not been well explored. In this study, survival were explored by tumor HPV status among 1) patients with OPSCCs race 2) nonoropharyngeal (non‐OP) head neck cancers (HNSCCs). METHODS This retrospective, multi‐institution study included non‐OP HNSCCs oral...
BACKGROUND The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing among older adults. It unknown whether these trends can be explained by human papillomavirus (HPV) and HPV‐related tumors remain associated with an improved prognosis patients. METHODS In a retrospective study OPSCCs diagnosed from 1995 to 2013 at 2 National Comprehensive Cancer Network–designated cancer centers, p16 immunohistochemistry in situ hybridization (ISH) for HPV‐16, high‐risk DNA, and/or E6/E7...
Human papillomavirus (HPV) causes an increasing proportion of oropharyngeal squamous cell carcinomas (OPSCCs), particularly in white men. The prevalence HPV among other demographic groups and anatomic sites HNSCC is unclear.To explore the role tumor status women nonwhites with OPSCC patients nonoropharyngeal head neck carcinoma (non-OP HNSCC).Retrospective cohort study at 2 tertiary academic centers including cases diagnosed 1995 through 2012, oversampled for minorities females. A stratified...
Abstract Objectives: To determine correlations between symptoms, nasal endoscopy findings, and computed tomography (CT) scan findings in post‐surgical chronic rhinosinusitis (CRS) patients. Study Design: Cross‐sectional. Material Methods: A total of 51 CRS patients who had undergone endoscopic sinus surgery (ESS) completed symptom questionnaires, underwent endoscopy, received an in‐office CT during one clinic visit. For metrics, we used the Sinonasal Outcomes Test‐20 (SNOT‐20) questionnaire,...
Research Article15 January 2018Open Access Transparent process Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement Elaine Emmerson orcid.org/0000-0002-5902-3368 Program in Craniofacial Biology, Department of Cell and Tissue University California, San Francisco, CA, USA Search for more papers by this author Alison J May Lionel Berthoin Noel Cruz-Pacheco Sara Nathan Aaron Mattingly Jolie L Chang Otolaryngology, William R Ryan D Tward...
Salivary proteins are essential for maintaining health in the oral cavity and proximal digestive tract, they serve as potential diagnostic markers monitoring human disease. However, their precise organ origins remain unclear. Through transcriptomic analysis of major adult fetal salivary glands integration with saliva proteome, blood plasma transcriptomes 28+ organs, we link to source, identify salivary-gland-specific genes, uncover fetal- adult-specific gene repertoires. Our results also...
ABSTRACT Objective Human Papillomavirus (HPV) is a well‐documented cause of cervical, oropharyngeal, vaginal, vulvar, anal, and penile cancers, largely preventable with the HPV vaccine. We aim to characterize most popular TikTok videos pertaining HPV‐associated cancers vaccination focus on oropharyngeal cancer. Methods Observational study public social media content. The top 200 that appeared when searching for #HPVvaccine #Gardasil individually were included analyzed basis creator...
To determine the diagnostic accuracy and ideal timing of fluoro-fluorodeoxyglucose positron-emission tomography (PET) in posttreatment surveillance head neck mucosal squamous cell carcinoma (HNSCC).Retrospective chart review.Our sample includes 103 adult patients with 118 PET scans who had undergone treatment for HNSCC. We correlated results surgical pathology clinical outcome subsequent 6 months.For detection locoregional persistent or recurrent HNSCC, a sensitivity 82%, specificity 92%,...
Investigation of human muscle regeneration requires robust methods to purify and transplant stem progenitor cells that collectively constitute the satellite cell (HuSC) pool. Existing approaches have yet make HuSCs widely accessible for researchers, as a result research has advanced slowly. Here, we describe predictable HuSC purification process is effective each skeletal tested development storage protocols transplantation models in dystrophin-deficient wild-type recipients. Enzymatic...
Objective In small (≤2 cm) oral tongue squamous cell carcinoma (OTSCC), we sought to clarify the contribution of pathologic features including perineural invasion (PNI), lymphovascular (LVI), and worst pattern invasion‐5 (WPOI‐5) clinical outcomes relative tumor depth (DOI) > or ≤ 4 mm. Methods Cases ≤2 cm OTSCC treated surgically between 2000 2017 at an academic cancer center were reviewed, with retrospective slide review DOI, LVI, PNI, WPOI‐5. Primary outcome measures included occult...
Objectives/Hypothesis Machine learning (ML) is a type of artificial intelligence wherein computer learns patterns and associations between variables to correctly predict outcomes. The objectives this study were 1) use ML platform identify factors important in predicting surgical complications patients undergoing head neck free tissue transfer, 2) compare outputs traditionally employed logistic regression models. Study Design Retrospective cohort study. Methods Using dataset 364 consecutive...
Objectives/Hypothesis Compare treatment‐related quality of life (QOL) impact for early‐stage human papillomavirus–associated oropharynx squamous cell carcinoma (HPV+ OPSCC) patients. Study Design Retrospective cohort at a tertiary center. Methods Stage I (T0‐2/N0‐1) HPV+ OPSCC patients (n = 76) with pretreatment Karnofsky scores ≥80 reported QOL after surgery alone 17, 22%), adjuvant radiation ± chemotherapy (S‐a[C]XRT) 23, 30%), or definitive (d[C]XRT) 36, 47%) the University Washington...
Abstract Objective This study aims to evaluate the prognostic impact of surgical margin status in HPV‐related oropharyngeal squamous cell carcinoma (OPSCCa) and examine potential for revising standards HPV+ OPSCCa. Study Design A retrospective cohort study. Setting was conducted across 4 tertiary oncology centers. Methods Charts patients treated from 2010 2022 OPSCCa were reviewed. Eligible underwent surgery without adjuvant treatment nonrecurrent, nonmetastatic Demographic, oncologic,...
Objectives/Hypothesis To prospectively assess symptoms of obstructive sialadenitis before and after sialendoscopy‐assisted salivary duct surgery (SASDS) using the chronic (COSS) questionnaire to determine predict impact interventions. Study Design Prospective cohort study. Methods Adult patients with who underwent SASDS were asked complete COSS Short‐Form‐8 (SF‐8) quality‐of‐life (QOL) survey prior 3 months postoperatively. Chronic surveys scored on a scale from 0 100. Results Forty...
Abstract Background Postoperative radioactive iodine (RAI) administration is widely utilized in patients with differentiated thyroid cancer. While beneficial select patients, it critical to recognize the potential negative sequelae of this treatment. The prevention, diagnosis, and management salivary lacrimal complications RAI exposure are addressed consensus statement. Methods A multidisciplinary panel experts was convened under auspices American Head Neck Society Endocrine Surgery Salivary...
The impact of close surgical margins on oncologic outcomes in HPV-related oropharyngeal squamous cell carcinoma (HPV + OPSCC) is unclear.Retrospective case series including patients undergoing single modality transoral robotic surgery (TORS) for HPV OPSCC at three academic medical centers from 2010 to 2019. Outcomes were compared between with (<1 mm or requiring re-resection) and clear using the Kaplan-Meier method.Ninety-nine included (median follow-up 21 months, range 6-121). Final 22...
To clarify the extent, timing, and patient perspectives of great auricular nerve (GAN) morbidity recovery after sacrifice during parotidectomy first postoperative year.Prospective series.Tertiary care academic medical center. Patients Twenty-seven consecutive patients who underwent with GAN sacrifice.Preoperatively at 3, 6, 9, 12 months postoperatively, we performed light touch sensation tests on each to develop an ink map representing anesthesia paresthesia in sensory territory; also...
Introduce the Chronic Obstructive Sialadenitis Symptoms (COSS) questionnaire to quantify chronic sialadenitis symptoms and assess impact of sialendoscopic-assisted salivary duct surgery (SASDS).Retrospective outcome study.The COSS assesses severity from 0 100. Patients who underwent SASDS April 2006 December 2013 completed ShortForm8 Health Survey (SF-8) based on current symptoms, reported whether they had complete, partial, or no symptomatic response SASDS.Sixty-six 156 (43%) contacted...
To prospectively assess symptoms before and after sialendoscopy-assisted salivary duct surgery (SASDS) in patients with symptomatic sialadenitis without sialolithiasis.Prospective cohort study.Patients chronic obstructive sialolithiasis (COSWS) completed the Chronic Obstructive Sialadenitis Symptoms (COSS) questionnaire prior to SASDS 3 months postoperatively.Of 80 consecutive a 20-month period, 20 surveyed underwent for COSWS 37 glands. Major symptom improvement (> 10 COSS score reduction)...
Human papillomavirus (HPV) is a principal driver for most oropharyngeal squamous cell carcinomas (OPSCCs), where it strongly associated with improved survival. HPV much less frequently detected in arising nonoropharyngeal sites (non-OPSCCs), and its pathogenic role prognostic value these tumors unclear. We evaluated the clinicopathologic features of 52 non-OPSCCs considered HPV-positive based upon p16 immunohistochemistry direct detection using RNA situ hybridization (ISH), DNA ISH, or...
The Salivary Gland Committee of the American Academy Otolaryngology-Head and Neck Surgery seeks to standardize terminology technique for ultrasonograpy used in evaluation treatment salivary gland disorders.
To clarify the extent and patient perspectives of great auricular nerve (GAN) morbidity recovery after sacrifice during parotidectomy 4 to 5 years surgery.Prospective series.Twenty-two patients who underwent with GAN were previously studied for sensory outcome first postoperative year. We performed light touch sensation tests on each develop an ink map representing anesthesia paresthesia in territory; also completed outcomes questionnaire.Nineteen (86%) 22 follow-up. One questionnaire over...