A5066240547- Voice and Speech Disorders
- Neuroscience of respiration and sleep
- Dysphagia Assessment and Management
- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Heart Rate Variability and Autonomic Control
- Nerve Injury and Rehabilitation
- Reconstructive Surgery and Microvascular Techniques
- Cardiac Arrest and Resuscitation
- Neurological disorders and treatments
- Facial Nerve Paralysis Treatment and Research
- Head and Neck Surgical Oncology
- Respiratory Support and Mechanisms
- Vascular Anomalies and Treatments
- Restraint-Related Deaths
- Botulinum Toxin and Related Neurological Disorders
- Sharing Economy and Platforms
- Body Contouring and Surgery
- Salivary Gland Tumors Diagnosis and Treatment
- Sleep and Wakefulness Research
- Ear and Head Tumors
- Vascular Malformations and Hemangiomas
- Transcranial Magnetic Stimulation Studies
- Neonatal Respiratory Health Research
University of Minnesota
2009-2024
Fairview Health Services
2024
Twin Cities Orthopedics
2001-2022
University of Minnesota Medical Center
1998-2021
University of Minnesota System
1989-2012
Hennepin County Medical Center
1990-2012
Minneapolis Institute of Arts
1996-2001
Medtronic (Ireland)
2001
American Otological Society
1998
Ann Arbor Center for Independent Living
1997
Background:Reduced upper airway muscle activity during sleep is fundamental to obstructive apnea (OSA) pathogenesis. Hypoglossal nerve stimulation (HGNS) counteracts this problem, with potential reduce OSA severity.
Objective. The aim of this research was to describe the postoperative respiratory complications after tonsillectomy and/or adenoidectomy (T A) in children with obstructive sleep apnea syndrome (OSAS), define which are at risk for these complications, and determine whether continuous positive airway pressure (CPAP) is an effective strategy dealing complications. Methods. data study were gathered through a retrospective chart review all 15 years age or younger polysomnographically (PSG) proven...
<h3>Background</h3> Hypoglossal nerve stimulation has been demonstrated to relieve upper airway obstruction acutely, but its effect on obstructive sleep apnea is not known. <h3>Objective</h3> To determine the response in electrical of hypoglossal nerve. <h3>Methods</h3> Eight patients with were implanted a device that stimulated unilaterally during inspiration. Sleep and breathing patterns examined at baseline before implantation after 1, 3, 6 months last follow-up. <h3>Results</h3>...
Summary Reduced upper airway muscle activity during sleep is a key contributor to obstructive apnea pathogenesis. Hypoglossal nerve stimulation activates dilator muscles, including the genioglossus, and has potential reduce severity. The objective of this study was examine safety, feasibility efficacy novel hypoglossal system ( HGNS ® ; Apnex Medical, St Paul, MN , USA ) in treating at 12 months following implantation. Thirty‐one subjects (35% female, age 52.4 ± 9.4 years) with moderate...
Electrical stimulation of the posterior cricoarytenoid muscle, when paced with inspiration, offers a physiological approach to restore ventilation in bilateral laryngeal paralysis without any disadvantages associated conventional treatment.A prospective study six patients.The patients were successfully implanted an Itrel II stimulator (Medtronic, Inc). In postoperative sessions, stimulated vocal fold abduction, patient ventilation, and voice assessed compared preoperative values.The optimum...
Objective To characterize the changes in anteroposterior dimensions of both retropalatal and retrolingual airway spaces pharynx hyoid bone position during hypoglossal nerve stimulation under general anesthesia subjects with obstructive sleep apnea. Study Design Cross‐sectional. Setting Academic center. Subjects Methods Cross‐table fluoroscopic images obtained were studied 26 enrolled Apnex Medical Hypoglossal Nerve Stimulation (HGNS) system feasibility trials. Changes (2‐dimensional)...
Abstract Objectives/Hypothesis: To describe the presentation, stenosis characteristics, etiological differences, and outcomes of adult laryngotracheal treated with endoscopic cold incision, balloon dilation, topical mitomycin C application, steroid injection. Study Design: Retrospective chart review. Methods: Demographic clinical data were extracted for patients between March 2000 December 2010. Prolonged intubation idiopathic patient utilized comparative analysis. Results: Eighty (65...
Abstract Objectives/Hypothesis : To evaluate the acoustic and perceptual results of laryngeal reinnervation with ansa cervicalis to recurrent nerve anastomosis. Study Design Retrospective study voice samples from 12 patients unilateral paralysis, treated Samples were recorded before surgery at least 8 months after surgery. Methods The subjected several analyses sensitive paralytic dysphonia, including cepstral peak prominence, noise‐to‐harmonics ratio, measures frequency amplitude...
The laryngeal chemoreflex (LCR) was investigated in 21 piglets (ages 6 to 80 days old) with the use of physiologic and histologic techniques. central projection superior nerve (SLN) determined 14 animals by horseradish peroxidase-wheat germ agglutinin. Ipsilateral labeling solitary tract nucleus seen. caudal extent varied age. Sensory ambiguus present bilaterally three younger unilaterally older piglets. Bilateral dorsomedialis seen all ages. Apneic cardiovascular response water stimulation...
Abstract Spasmodic dysphonia (SD) is an incurable focal dystonia of the larynx that impairs speech and communication. Vibro-tactile stimulation (VTS) alters afferent proprioceptive input to sensorimotor cortex controls speech. This proof-of-concept study examined effect laryngeal VTS on quality cortical activity in 13 SD participants who vocalized vowel /a/ while receiving for 29 minutes. In response VTS, 9 (69%) exhibited a reduction voice breaks and/or meaningful increase smoothed cepstral...
Reduced intracortical inhibition is a neurophysiologic finding in focal dystonia that suggests broader problem of impaired cortical excitability within the brain. A robust understanding neurophysiology essential to elucidate pathophysiology disorder and develop new treatments. The silent period (cSP) reliable, non-invasive method measure primary motor cortex associated with muscle interest. In adductor spasmodic dysphonia (AdSD), cSP laryngeal (LMC) which directly corresponds affected...
Abstract Hypoglossal nerve stimulation was investigated as a method to relieve an induced upper airway obstruction. Six dogs were implanted with cuff electrode applied each hypoglossal and pulse generator. After 4 weeks, the stimulated (50% duty cycle) for up 8 weeks. At 12 weeks double tracheotomy placed, negative pressure intermittently limb, simulating inspiratory pressure. Unilateral improved peak flow from average of 0.1 L/s 1.6 ( P = 0.0001). Seventy‐seven percent maximum possible...
In normal mature limb skeletal muscle, satellite cells are quiescent and myonuclei do not divide after formation of their associated myofibers in the absence injury. The possibility myonuclear addition uninjured laryngeal adult rabbits was investigated an immunohistochemical pilot study.Bromodeoxyuridine (brdU), a marker for cell division, administered by intraperitoneal injection over 12-hour period rabbits. number brdU-positive per myofiber determined on cross sections through...
Abstract Background The aim of this pilot study is to evaluate office‐based sclerotherapy using sodium tetradecyl sulfate (STS) for epistaxis due hereditary hemorrhagic telangiectasias (HHT). Patients with HHT suffer from unpredictable, recurrent, severe nasal bleeding necessitating emergency care, packing, blood transfusions, and invasive procedures. Methods In retrospective 7 patients a history treatment recurrent were treated in an setting intralesional injection STS. Treatment results...
Objectives/Hypothesis Voice rest is frequently recommended following surgical disruption of vocal fold epithelium, but patients report variable adherence to voice recommendations. The objective this study was assess the clinical utility an ambulatory dosimeter for measuring Study Design Outcomes research. Methods Part 1: To determine in nonclinical use, relationship between self‐reported use and measurements examined normal subjects (n = 11) who prospectively logged while wearing dosimeter....
Background Laryngeal dystonia is a task-specific focal of laryngeal muscles that impairs speech and voice production. At present, there no cure for LD. The most common therapeutic option patients with LD involves Botulinum neurotoxin injections. Objective Provide empirical evidence non-invasive vibro-tactile stimulation (VTS) the skin over box can provide symptom relief to those affected by Methods Single-group 11-week randomized controlled trial crossover between two dosages (20 min VTS...
Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare idiopathic proliferative disorder of histiocytes characteristic morphologic features. We describe case SHML occurring in 14-yr-old black male, whom the diagnosis was made by fine-needle aspiration cervical lymph node. Cytologic features included increased numbers large associated polymorphous, cellular background composed benign lymphocytes, plasma cells, and polymorphonuclear leukocytes. Lymphophagocytosis prominent feature....
Background The aim of this study was to identify and evaluate adverse clinical outcomes following office‐based sclerotherapy using sodium tetradecyl sulfate (STS) for epistaxis due hereditary hemorrhagic telangiectasias (HHT or Osler‐Weber‐Rendu). Methods A retrospective chart review 36 adult patients treated with STS severe and/or recurrent HHT performed. Results total 153 separate treatment sessions were analyzed. Each patient underwent an average 4.3 7 intralesional injections per...
To compare the efficacy of endoscopic medial and lateral orbital wall surgery to 3-wall decompression in patients with thyroid eye disease.A retrospective study disease severe proptosis, exposure keratitis, or compressive optic neuropathy was conducted.Mean reduction proptosis 4.37 mm 2-wall approach 4.59 group. Seventy-five percent group demonstrated improved visual acuity; 50% after decompression. Vertical palpebral fissure height decreased by an average 2.50 2.03 New onset diplopia 11.8%...
Objective: This work aimed to evaluate the cortical silent period (cSP) of laryngeal motor cortex (LMC) using bilateral thyroarytenoid (TA) muscles with transcranial magnetic stimulation (TMS). Methods: In 11 healthy participants, fine-wire electromyography (EMG) was used record TA muscle responses single pulse TMS delivered LMC in both hemispheres. Peripheral over mastoid, where vagus nerve exits skull, were collected verify central origin by comparing latencies. Results: The cSP duration...
OBJECTIVE To examine the effect of recurrent laryngeal nerve section on myonuclear addition and myofiber remodeling in adult rabbit muscles. STUDY DESIGN AND SETTING Unilateral was performed rabbits. Rabbits were labeled with bromodeoxyuridine, euthanized, muscles examined for bromodeoxyuridine (brdU) neonatal myosin heavy chain (MyHC) expression. RESULTS One week after section, brdU‐positive myonuclei significantly increased denervated contralateral sides. Neonatal MyHC expression...