A5060960336- Botulinum Toxin and Related Neurological Disorders
- Vagus Nerve Stimulation Research
- Neurological disorders and treatments
- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- Pain Management and Treatment
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Muscle activation and electromyography studies
- Parkinson's Disease Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
- Cardiac Arrhythmias and Treatments
- Advanced Neuroimaging Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Balance, Gait, and Falls Prevention
- Stuttering Research and Treatment
- Functional Brain Connectivity Studies
- Children's Physical and Motor Development
- Cytomegalovirus and herpesvirus research
- Voice and Speech Disorders
- Academic Research in Diverse Fields
- Biochemical and Molecular Research
- Motor Control and Adaptation
- Intraoperative Neuromonitoring and Anesthetic Effects
- Hearing, Cochlea, Tinnitus, Genetics
MicroTransponder (United States)
2018-2023
University of Minnesota Medical Center
2023
University of Minnesota
2017-2021
Emory University
2012-2017
Universidade Federal de Minas Gerais
2008-2013
Cervical dystonia is a neurological disorder characterized by sustained, involuntary movements of the head and neck. Most cases cervical are idiopathic, with no obvious cause, yet some acquired, secondary to focal brain lesions. These latter valuable as they establish causal link between neuroanatomy resultant symptoms, lending insight into regions causing possible treatment targets. However, lesions can occur in multiple different locations, leaving localization unclear. Here, we use...
Background and Purpose— We assessed safety, feasibility, potential effects of vagus nerve stimulation (VNS) paired with rehabilitation for improving arm function after chronic stroke. Methods— performed a randomized, multisite, double-blinded, sham-controlled pilot study. All participants were implanted VNS device received 6-week in-clinic followed by home exercise program. Randomization was to active (n=8) or control (n=9) rehabilitation. Outcomes at days 1, 30, 90 post-completion therapy....
To assess whether a long-term home-based intervention using Paired VNS therapy is feasible and the benefits of are maintained beyond 1 year.A follow-up study.Three centers in United States Kingdom.Adults with chronic ischemic stroke (n=15) moderate to severe arm hand impairment.Participants were implanted device followed by 6 weeks in-clinic (Active) or control rehabilitation through day 90 (blinded phase). The group then crossed over receive Active VNS. Participants both groups continued...
A Doença de Parkinson (DP) é uma doença crônica e degenerativa do sistema nervoso central que afeta principalmente pessoas acima 50 anos. Estudos avaliaram a qualidade vida (QV) em parkinsonianos revelaram significativo impacto negativo da nesses indivíduos. O Disease Questionnaire39 (PDQ-39) tem sido indicado como instrumento mais apropriado para avaliação QV indivíduo com DP. OBJETIVO: Avaliar percepção indivíduos DP Ambulatório Distúrbios Movimento Instituição, através PDQ-39. MÉTODO:...
Background. Vagus nerve stimulation (VNS) paired with rehabilitation may improve upper-limb impairment and function after ischemic stroke. Objective. To report 1-year safety, feasibility, adherence, outcome data from a home exercise program VNS using long-term follow-up randomized double-blind study of therapy Active (n = 8) or Control 9). Methods. All people were implanted device underwent 6 weeks in clinic followed by exercises through day 90. Thereafter, participants investigators...
Abstract Cervical dystonia (CD) is a neurological disorder with typical symptoms of involuntary and abnormal movements postures the head. CD‐associated alterations functional brain networks have not been well characterized. Previous studies CD using resting‐state MRI (rfMRI) are limited in two aspects: (i) analyses were directly focused on network related to head movement (ii) rfMRI measurements other than connectivity (FC) investigated. The present study examined FC by capitalizing newly...
Objective Lesch–Nyhan disease (LND) is caused by congenital deficiency of the purine recycling enzyme, hypoxanthine‐guanine phosphoribosyltransferase (HGprt). Affected patients have a peculiar neurobehavioral syndrome linked with reductions dopamine in basal ganglia. The purpose current studies was to determine anatomical basis for reduced human brain specimens collected at autopsy. Methods Histopathological were conducted using autopsy tissue from 5 LND cases and 6 controls. Specific...
Background Vagus Nerve Stimulation (VNS) paired with rehabilitation improved upper extremity impairment and function in a recent pivotal, randomized, triple-blind, sham-controlled trial people chronic arm weakness after stroke. Objective We aimed to determine whether treatment effects varied across candidate subgroups, such as younger age or less injury. Methods Participants were randomized receive active VNS sham stimulation (Control). The primary outcome was the change measured by...
Objective The aim of this study was to compare electromyographic activities between and within the paretic nonparetic lower limb muscles during sit-to-stand (STS) task in subjects with hemiparesis as a result stroke. Design This is cross-sectional study. Results All monitored both limbs remained active most task; were activated before seat-off reached maximum peak activity after (P < 0.01). As compared limb, exhibited earlier activation hamstrings 0.01); longer period higher tibialis...
Cervical dystonia (CD) is a neurological disorder characterized by abnormal movements and postures of the head. The brain regions responsible for these are not well understood, because most imaging techniques assessing regional activity cannot be used when head moving. Recently, we mapped activation in healthy individuals using functional magnetic resonance (fMRI) during isometric rotation, muscle contractions occur without actual movements. In current study, same methods to explore neural...
Vagus nerve stimulation (VNS) paired with a motor task improves outcome in rat stroke models. It is hypothesised that VNS delivered during rehabilitation will improve upper limb function compared to control therapy. Two pilot clinical studies demonstrated acceptable safety and feasibility of for improved after stroke. Participants who received clinically meaningful improvements exceed gains seen among controls similar without VNS. These preliminary data support larger pivotal trial.VNS-REHAB...
Reduced intracortical inhibition is a neurophysiologic finding in focal dystonia that suggests broader problem of impaired cortical excitability within the brain. A robust understanding neurophysiology essential to elucidate pathophysiology disorder and develop new treatments. The silent period (cSP) reliable, non-invasive method measure primary motor cortex associated with muscle interest. In adductor spasmodic dysphonia (AdSD), cSP laryngeal (LMC) which directly corresponds affected...
Purpose. To identify which paretic and non-paretic muscular groups of the lower limbs were best predictors gait speed in chronic hemiparetic subjects.Method. Twelve subjects with ages ranging from 65 to 75 years (70.67 ± 3.31 years) included this cross-sectional study. All participants had time since onset stroke at least six months ability walk independently. Main outcome measures self-selected maximum isometric torques both limbs. Pearson's correlation coefficients stepwise regression...
Objective: This work aimed to evaluate the cortical silent period (cSP) of laryngeal motor cortex (LMC) using bilateral thyroarytenoid (TA) muscles with transcranial magnetic stimulation (TMS). Methods: In 11 healthy participants, fine-wire electromyography (EMG) was used record TA muscle responses single pulse TMS delivered LMC in both hemispheres. Peripheral over mastoid, where vagus nerve exits skull, were collected verify central origin by comparing latencies. Results: The cSP duration...
The neural systems controlling head movements are not well delineated in humans. It is clear whether the ipsilateral or contralateral primary motor cortex involved turning right left. Furthermore, exact location of neck area somatotopic organization homunculus still debated and evidence for contributions from other brain regions humans scarce. Because currently available neuroimaging methods generally suitable mapping activation patterns during movements, we conducted fMRI scans isometric...
The purpose of this case report is to describe pairing vagus nerve stimulation (VNS) with mobility training in an individual after stroke.A 53-year-old man left hemiparesis 14.2 months ischemic stroke participated a pilot study investigating the safety and feasibility VNS paired upper limb rehabilitation. In addition impairment, participant had impaired gait wanted improve his mobility. A single-subject design investigation self-directed was conducted. Following conclusion study, instructed...