A5008595989- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Forensic Anthropology and Bioarchaeology Studies
- Morphological variations and asymmetry
- Pleistocene-Era Hominins and Archaeology
- Climate variability and models
- Genital Health and Disease
- Meteorological Phenomena and Simulations
- Avian ecology and behavior
- Environmental Toxicology and Ecotoxicology
- Wildlife Ecology and Conservation
- Archaeology and ancient environmental studies
- Forensic and Genetic Research
- Molecular Biology Techniques and Applications
- Reproductive tract infections research
- Energy Load and Power Forecasting
- Helicobacter pylori-related gastroenterology studies
- Archaeological and Geological Studies
- Atmospheric and Environmental Gas Dynamics
- Tropical and Extratropical Cyclones Research
- Marine Bivalve and Aquaculture Studies
- dental development and anomalies
- Venous Thromboembolism Diagnosis and Management
- Veterinary Orthopedics and Neurology
- Isotope Analysis in Ecology
Universidad Nacional de La Plata
2015-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2025
Hospital El Cruce
2020-2025
Hospital Universitari de Santa Maria
2025
Complexo Hospitalario Universitario A Coruña
2019-2025
Universidad Nacional Arturo Jauretche
2025
Puigvert Foundation
2025
Universitat Autònoma de Barcelona
2025
Instituto de Investigación Biomédica de A Coruña
2023-2025
Wellesley College
2025
NOWLEDGE THAT INFECTIONwith 1 of approximately 15 oncogenic human papillomavirus (HPV) types is required for the development cervical cancer has permitted primary prevention efforts via vaccination. 1][4][5] One vaccine (Gardasil) a quadrivalent HPV-16/18 candidate that contains VLPs from 2 HPV types, HPV-16 and HPV-18, also 6 11, which are not involved in pathogenesis but linked to benign genital warts.
Most populations of migrant shorebirds around the world are in serious decline, suggesting that vital condition-dependent rates such as fecundity and annual survival being affected globally. A striking example is red knot (Calidris canutus rufa) population wintering Tierra del Fuego, which undertakes marathon 30,000 km hemispheric migrations annually. In spring, birds forage voraciously on horseshoe crab eggs Delaware Bay eastern USA before departing to breed Arctic polar deserts. From 1997...
Background Human papillomavirus (HPV) infection, particularly with type 16, causes a growing fraction of oropharyngeal cancers, whose incidence is increasing, mainly in developed countries. In double-blind controlled trial conducted to investigate vaccine efficacy (VE) the bivalent HPV 16/18 against cervical infections and lesions, we estimated VE prevalent oral 4 years after vaccination. Methods Findings A total 7,466 women 18–25 old were randomized (1∶1) receive HPV16/18 or hepatitis as...
Abstract Over the last decade, geometric morphometric methods have been applied increasingly to study of human form. When too few landmarks are available, outlines can be digitized as series discrete points. The individual points must slid along a tangential direction so remove variation, because contours should homologous from subject whereas their need not. This variation removed by minimizing either bending energy (BE) or Procrustes distance (D) with respect mean reference Because these...
Three-dose regimens for human papillomavirus (HPV) vaccines are expensive and difficult to complete, especially in settings where the need cervical cancer prevention is greatest. We evaluated vaccine efficacy of fewer than three doses HPV16/18 Cervarix our Costa Rica Vaccine Trial. Women were randomly assigned receive or a control followed incident HPV16 HPV18 infection that persisted visits 10 more months apart (median follow-up 4.2 years). After excluding women who had no DNA positive at...
Decadal predictions have a high profile in the climate science community and beyond, yet very little is known about their skill. Nor there any agreed protocol for estimating This paper proposes sound coordinated framework verification of decadal hindcast experiments. The illustrated hindcasts tailored to meet requirements specifications CMIP5 (Coupled Model Intercomparison Project phase 5). chosen metrics address key questions information content initialized hindcasts. These are: (1) Do...
Objective. We investigated coinfection patterns for 25 human papillomavirus (HPV) types and assessed the risk conferred by multiple HPV toward cervical disease.
Background Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections. However, only a small percentage high-risk (HR) HPV infections progress to cervical precancer and cancer. In this study, we investigated role cervicovaginal microbiome (CVM) in natural history HR-HPV. Methods This study was nested within placebo arm Costa Rica Vaccine Trial that included women aged 18–25 years age. Cervical samples from two visits with an incident HR-HPV (n = 273 women)...
This overview describes the principles of 4th edition European Code against Cancer and provides an introduction to 12 recommendations reduce cancer risk. Among 504.6 million inhabitants member states Union (EU28), there are annually 2.64 new cases 1.28 deaths from cancer. It is estimated that this burden could be reduced by up one half if scientific knowledge on causes translated into successful prevention. The a preventive tool aimed informing people how avoid or carcinogenic exposures,...
Abstract The Costa Rica HPV16/18 Vaccine Trial (CVT) showed that four-year vaccine efficacy against 12-month persistent infection was similarly high among women who received one, two, or the recommended three doses of bivalent L1 virus-like particle (VLP) vaccine. Live-attenuated viral vaccines, but not simple-subunit usually induce durable lifelong antibody responses after a single dose. It is unclear whether noninfectious VLP vaccines behave more like live-virus in this regard. To explore...
Abstract Background The authors investigated the durability of vaccine efficacy (VE) against human papillomavirus (HPV)16 or 18 infections and antibody response among nonrandomly assigned women who received a single dose bivalent HPV compared with multiple doses unvaccinated women. Methods were between HPV16 18-vaccinated aged to 25 years one (N = 112), two 62), three 1365) doses, age- geography-matched 1783) in long-term follow-up Costa Rica Vaccine Trial. Cervical measured at study visits,...
Abstract Extreme weather events have devastating impacts on human health, economic activities, ecosystems, and infrastructure. It is therefore crucial to anticipate extremes their allow for preparedness emergency measures. There indeed potential probabilistic subseasonal prediction time scales of several weeks many extreme events. Here we provide an overview predictability case studies some the most prominent across globe using ECMWF S2S system: heatwaves, cold spells, heavy precipitation...
A subset of climate simulations the 20th century from IPCC‐AR4 is analyzed to assess ability these models reproduce observed climatological seasonal precipitation in South America during period 1970–1999. Changes model climatology a change scenario (SRESA1b) for 2070–2099 are also discussed. Results show that able main features cycle over America, although SACZ region and maximum southeastern cold season not well‐ represented. There general consensus among changes projected mainly: i) an...
SUMMARY The dramatic improvement in neonatal care during the last decade did not succeed reducing incidence of periventricular leukomalacia (PVL), suggesting that prenatal events may be main target for PVL prevention. studied cohort included 753 very preterm infants born between 24 and 32 weeks gestational age, admitted to intensive unit surviving at least 7 days; 69 (9.2%) these had a diagnosis cystic PVL. highest frequency was observed among bom 28 gestation (16%). Inflammatory occurring...
Abstract Understanding patterns of connectivity among populations marine organisms is essential for the development realistic, spatially explicit models population dynamics. Two approaches, empirical genetic and oceanographic dispersal modelling, have been used to estimate levels evolutionary but rarely their potentially complementary insights combined. Here, a realistic Lagrangian model larval theoretical are integrated with most extensive study gene flow in Caribbean organism. The 871...
Infection with human papillomavirus (HPV) 16 or HPV18 elicits an antibody response, but whether the elicited antibodies protect women against subsequent infection by a homologous HPV type compared seronegative is unknown.Study participants were aged 18-25 years at enrollment in control group of ongoing National Cancer Institute-sponsored, community-based, randomized HPV16/18 Costa Rica Vaccine Trial. At enrollment, 2813 negative for cervical HPV16 DNA and 2950 DNA. Women interviewed...
Target groups for human papillomavirus (HPV) vaccination are controversial. We evaluated vaccine efficacy (VE) against 1-year persistent infection, stratified by age and sexual behavior, among young women in Costa Rica. randomized 7,466 healthy 18 to 25 years of HPV16/18 or hepatitis A (follow-up, 50.4 months). According-to-protocol (ATP) cohorts included compliant HPV-negative women; intention-to-treat (ITT) all women. ATP VE was 90.9% (95% CI, 82.0-95.9) infections, 44.5% HPV31/33/45...