A5024132730- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Systemic Lupus Erythematosus Research
- Family and Disability Support Research
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Rheumatoid Arthritis Research and Therapies
- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- Monoclonal and Polyclonal Antibodies Research
- Employment and Welfare Studies
- Liver Diseases and Immunity
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Esophagitis
- Musculoskeletal Disorders and Rehabilitation
- T-cell and B-cell Immunology
- Parvovirus B19 Infection Studies
- Renal Diseases and Glomerulopathies
- Retirement, Disability, and Employment
- Workplace Health and Well-being
- Spondyloarthritis Studies and Treatments
- Salivary Gland Disorders and Functions
- Peripheral Neuropathies and Disorders
- Systemic Sclerosis and Related Diseases
British Columbia Children's Hospital
2016-2025
University of British Columbia
2016-2025
Kaiser Permanente
2024
University of Alberta
2023
University of Saskatchewan
2023
British Columbia Institute of Technology
2022
Memorial Hospital
2022
Digital Research Alliance of Canada
2019
McGill University Health Centre
2018-2019
University of Manitoba
2019
This study examines the differences which may distinguish systemic lupus erythematosus (SLE) presenting in adult life or childhood. A common database was established, with analysis of clinical, serological and outcome features a cohert patients SLE, disease diagnosed before age 16 (n = 39) after 165). Disease onset generally more severe childhood-onset patients. Cardiopulmonary older-onset group, but major haematological manifestations were frequent group. Serologically, anti-DNA, anti-Sm...
<h3>Objective</h3> To describe clinical outcomes of juvenile idiopathic arthritis (JIA) in a prospective inception cohort children managed with contemporary treatments. <h3>Methods</h3> Children newly diagnosed JIA at 16 Canadian paediatric rheumatology centres from 2005 to 2010 were included. Kaplan–Meier survival curves for each category used estimate probability ever attaining an active joint count 0, inactive disease (no joints, no extraarticular manifestations and physician global...
To determine the feasibility of a 12-week Internet-based self-management program disease-specific information, strategies, and social support with telephone for youth juvenile idiopathic arthritis (JIA) their parents, aimed at reducing physical emotional symptoms improving health-related quality life (HRQOL).A nonblind pilot randomized controlled trial (NCT01011179) was conducted to test "Teens Taking Charge: Managing Arthritis Online" Internet intervention across 4 tertiary-level centers in...
A new bilingual (English and French) Internet-based self-management program, Teens Taking Charge: Managing Arthritis Online, for adolescents with arthritis their parents was developed following a needs assessment.This study explored the usability (user performance satisfaction) of program youth juvenile idiopathic (JIA) to refine health portal prototype.A qualitative design semi-structured, audio taped interviews observation by trained observer undertaken two iterative cycles determine (ease...
Abstract Objective To determine whether neutrophil gelatinase–associated lipocalin (NGAL) can predict worsening of global and renal disease activity in childhood‐onset systemic lupus erythematosus (SLE). Methods One hundred eleven patients with SLE were enrolled a longitudinal, prospective study quarterly visits had at least 3 visits. At each visit, was measured using external standards: the numerically converted British Isles Lupus Assessment Group (BILAG) index, Disease Activity Index 2000...
The digital transformation of the economy is characterized by rapid advancement and wide-spread workplace application technologies. Our study aimed to unpack how contributes challenges opportunities for sustainable employment health persons living with disabilities. One-on-one semi-structured interviews policy makers, disability service providers future work specialists were conducted. Interviewees asked about implications technology advancements Participants also strategies that could be...
Abstract Objective To evaluate features during the first 6 months of disease that may be associated with a poor outcome as measured principally by extension to polyarticular course in patients oligoarticular‐onset juvenile rheumatoid arthritis (oligo‐JRA). Methods This study was retrospective review who fulfilled American College Rheumatology criteria for oligo‐JRA, were followed up at least 5 years, and did not have psoriatic arthritis, spondylarthropathy‐like disease, or factor positivity....
Abstract Objective To determine early outcomes and improvements in a prospective inception cohort of children with juvenile idiopathic arthritis (JIA) treated current standard therapies. Methods Patients selected were enrolled an JIA, the Research Arthritis Canadian Children Emphasizing Outcomes Study. The rheumatoid core criteria set measures completed at enrollment 6 months later. Frequencies normal values for each American College Rheumatology (ACR) Pediatric 30, 50, 70 (Pedi 70) response...
<h3>Objective</h3> To describe probabilities and characteristics of disease flares in children with juvenile idiopathic arthritis (JIA) to identify clinical features associated an increased risk flare. <h3>Methods</h3> We studied the Research Arthritis Canadian Children emphasizing Outcomes (ReACCh-Out) prospective inception cohort. A flare was defined as a recurrence manifestations after attaining inactive called significant if it required intensification treatment. Probability first...
To develop system-level performance measures for evaluating the care of patients with inflammatory arthritis (IA), including rheumatoid (RA), psoriatic arthritis, ankylosing spondylitis, and juvenile idiopathic arthritis.This study involved several methodological phases. Over multiple rounds, various participants were asked to help define a set candidate measurement themes. A systematic search was conducted existing guidelines measures. 6 defined presented 50 people, IA, rheumatologists,...
Noninvasive estimation of the degree inflammation seen on kidney biopsy with lupus nephritis (LN) remains difficult. The objective this study was to develop a Renal Activity Index for Lupus (RAIL) that, based solely laboratory measures, accurately reflects histologic LN activity.We assayed traditional tests and 16 urine biomarkers (UBMs) in children (n = 47) at time biopsy. Histologic activity measured by National Institutes Health index (NIH-AI) tubulointerstitial (TIAI). High LN-activity...
Abstract Introduction The future of work is characterized by changes that could disrupt all aspects the nature and availability work. Our study aims to understand how result in conditions, which contribute vulnerability for different groups workers. Methods A horizon scan was conducted systematically identify synthesize diverse sources evidence, including academic gray literature resources shared over social media. Evidence synthesized, trend categories were developed through iterative...
Abstract Objective To measure aerobic fitness (maximum oxygen consumption [V O 2peak ]), fatigue, quality of life (QOL), and disease activity in young persons with systemic lupus erythematosus (SLE), to determine an equation for predicting V from the distance walked 6 minutes (6MW). Methods Fifteen patients ages 12–19 years SLE participated. 2 was measured by a graded treadmill exercise test. Submaximal intensity determined ventilatory anaerobic threshold. capacity using 6MW. Patient...
Abstract Objective To determine early predictors of 6‐month outcomes in a prospective cohort patients with juvenile idiopathic arthritis (JIA). Methods Patients selected were those enrolled an inception study JIA, the Research Arthritis Canadian Children Emphasizing Outcomes Study, within 6 months after diagnosis. The rheumatoid core criteria set and quality life measures collected at enrollment later. evaluated included inactive disease, Juvenile Quality Life Questionnaire (JAQQ) scores,...