A5063009703- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- Renal Diseases and Glomerulopathies
- Inflammatory Myopathies and Dermatomyositis
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
- Lipid metabolism and disorders
- Lymphoma Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- Neurogenetic and Muscular Disorders Research
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Biochemical and Molecular Research
- Dermatological and Skeletal Disorders
George Washington University
2021-2025
University of Alabama at Birmingham
2022
Alberta Children's Hospital
2021
University of California, San Francisco
2021
University of Calgary
2021
Children's National
2011-2020
Boston University
2018
National Defence Medical Centre
2012
University of Nebraska at Omaha
2012
Creighton University
1996-2011
Tumor necrosis factor (TNF) has a pathogenic role in juvenile rheumatoid arthritis. We evaluated the efficacy and safety of adalimumab, fully human monoclonal anti-TNF antibody, children with polyarticular-course arthritis.Patients 4 to 17 years age active arthritis who had previously received treatment nonsteroidal antiinflammatory drugs underwent stratification according methotrexate use 24 mg adalimumab per square meter body-surface area (maximum dose, 40 mg) subcutaneously every other...
With human T cells activated by 12-o-tetradecanoyl phorbol-13-acetate (TPA) as immunogen, an IgG2a mAb, early activation antigen 1 (EA 1), was generated against a 60-kD protein with disulfide-linked 28-kD and 32-kD subunits. Both subunits were phosphorylated. The antigen, EA 1, readily detected on approximately 60% of isolated cryopreserved thymocytes, determined indirect immunofluorescence. A low level expression detectable 6-7% blood lymphocytes. TPA-activated expressed 30 min after...
We compared the safety and efficacy of leflunomide with that methotrexate in treatment polyarticular juvenile rheumatoid arthritis a multinational, randomized, controlled trial.Patients 3 to 17 years age received or for 16 weeks double-dummy, blinded fashion, followed by 32-week extension. The rates American College Rheumatology Pediatric 30 percent responses (ACR Pedi 30) Percent Improvement Index were assessed at baseline every 4 8 during extension study.Of 94 patients 86 completed...
To formulate consensus treatment plans (CTPs) for induction therapy of newly diagnosed proliferative lupus nephritis (LN) in juvenile systemic erythematosus (SLE).A structured formation process was employed by the members Childhood Arthritis and Rheumatology Research Alliance after considering existing medical evidence current approaches.After an initial Delphi survey (response rate = 70%), a 2-day conference, 2 followup surveys rates 63-79%), achieved limited set CTPs addressing LN. These...
The production of TNF/cachectin by human B cell lines and tonsillar cells was examined. Of the 15 examined, 9 synthesize TNF mRNA constitutively. PMA stimulated most to accumulate increased amounts TNF. SeD, 8866P, 32al, RPMI 1788, four bone marrow-derived EBV-transformed accumulated high levels when PMA. these 1788 WIH8 produced little constitutively, but synthesized 5-7 ng/ml A pre-B line, Nalm-6, did not any detectable amount mRNA, even with stimulation. Tonsillar could also be produce or...
Statins reduce atherosclerosis and cardiovascular morbidity in the general population, but their efficacy safety children adolescents with systemic lupus erythematosus (SLE) are unknown. This study was undertaken to determine 3-year of atorvastatin preventing subclinical progression pediatric-onset SLE.
To evaluate risk factors for subclinical atherosclerosis in a population of patients with pediatric systemic lupus erythematosus (SLE).In prospective multicenter study, cohort 221 underwent baseline measurements carotid intima-media thickness (CIMT) as part the Atherosclerosis Prevention Pediatric Lupus Erythematosus (APPLE) trial. SLE disease measures, medications, and traditional were assessed. A standardized protocol was used to assess bilateral common arteries mean maximal IMT 12...
As an acute febrile and inflammatory disease, Kawasaki disease (KD) could develop shock syndrome (KDSS) sometimes. However its pathogenesis was still not well known. This study to learn more about the clinical features evaluate role of cytokines in KDSS.We collected laboratory data retrospectively for all patients with KDSS(KDSS, n = 27)who were hospitalized at our hospital from Jan 2014 Oct 2017. For patient KDSS, we randomly identified 43 KD as control subjects (KD, 43). Clinical features,...
A monoclonal antibody, AT-1, is shown to precipitate a p60-65 molecule identical the Tac antigen. With expression of IL-2 receptors by normal activated human B cells from peripheral blood and tonsils documented biosynthetic immunofluorescence studies. AT-1 precipitated protein [35S]methionine-labeled cells, similar that T cells. The interleukin 2 (IL-2) receptor appeared shortly after activation with anti-IgM cell-stimulatory factor(s). Its reached its peak at 60-72 h approximately 50%...
Objective Participants in the Atherosclerosis Prevention Paediatric Lupus Erythematosus (APPLE) trial were randomised to placebo or atorvastatin for 36 months. The primary endpoint, reduced carotid intima medial thickness (CIMT) progression, was not met but atorvastatin-treated participants showed a trend of slower CIMT progression. Post-hoc analyses performed assess subgroup benefit from therapy. Methods Subgroups prespecified and defined by age (> ≤15.5 years), systemic lupus...
Noninvasive estimation of the degree inflammation seen on kidney biopsy with lupus nephritis (LN) remains difficult. The objective this study was to develop a Renal Activity Index for Lupus (RAIL) that, based solely laboratory measures, accurately reflects histologic LN activity.We assayed traditional tests and 16 urine biomarkers (UBMs) in children (n = 47) at time biopsy. Histologic activity measured by National Institutes Health index (NIH-AI) tubulointerstitial (TIAI). High LN-activity...
We report the safety, tolerability and efficacy of tofacitinib in patients with juvenile idiopathic arthritis (JIA) an ongoing long-term extension (LTE) study.
Abstract Objective To assess health‐related quality of life (HRQOL) in abatacept‐treated children/adolescents with juvenile idiopathic arthritis (JIA). Methods In this phase III, double‐blind, placebo‐controlled trial, subjects active polyarticular course JIA and an inadequate response/intolerance to ≥1 disease‐modifying antirheumatic drug (including biologics) received abatacept 10 mg/kg plus methotrexate (MTX) during the 4‐month open‐label period (period A). Subjects achieving American...
Objective. The aim was to assess environmental factors associated with disease flare in juvenile and adult dermatomyositis (DM). Methods. An online survey of DM patients from the USA Canada examined smoking, sun exposure, infections, medications, vaccines, stressful life events physical activity during 6 months before flares, or past without flares. Differences were evaluated by χ2 Fisher's exact tests, significant univariable results multivariable logistic regression. Residential locations...
Objective To determine the relationship between serum levels of S100A8/A9 and S100A12 maintenance clinically inactive disease during anti–tumor necrosis factor (anti‐ TNF ) therapy occurrence flare following withdrawal anti‐ in patients with polyarticular forms juvenile idiopathic arthritis (JIA). Methods In this prospective, multicenter study, 137 polyarticular‐course JIA whose was while receiving were enrolled. Patients observed for an initial 6‐month phase which treatment continued. For...
Objective. Granulomatosis with polyangiitis (Wegener’s; GPA) and other antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare in childhood sometimes difficult to discriminate. We compared use of adult-derived classification schemes for GPA against validated pediatric criteria the ARChiVe (A Registry Childhood Vasculitis e-entry) cohort, a Arthritis Rheumatology Research Alliance initiative. Methods. Time-of-diagnosis data children physician (MD) diagnosis AAV...
A T cell surface membrane-associated glycoprotein, Tp40 (40,000 mol wt), also designated as CD-7, was not expressed by the cells of a patient with severe combined immunodeficiency. In addition to this abnormality, proliferative responses mitogens were defective and IL-2 receptor expression deficient on patient's lymphocytes. However, his found provide help for differentiation normal B Ig-secreting cells. Abundant circulating detected. These proliferated normally in presence anti-mu...
To validate clinical indices of lupus nephritis activity and damage when used in children against the criterion standard kidney biopsy findings.In 83 requiring biopsy, Systemic Lupus Erythematosus Disease Activity Index renal domain (SLEDAI-R), British Isles Assessment Group index (BILAG-R), International Collaborating Clinics (SLICC) score (SLICC-RAS), SLICC Damage (SDI-R) were measured. Fixed effects logistic models calculated to predict Society Nephrology/Renal Pathology (ISN/RPS) class;...
Objective To determine the frequency, time to flare, and predictors of disease flare upon withdrawal anti–tumor necrosis factor (anti‐ TNF ) therapy in children with polyarticular forms juvenile idiopathic arthritis ( JIA who demonstrated ≥6 months continuous clinically inactive disease. Methods In 16 centers 137 patients were receiving anti‐ (42% whom also methotrexate [ MTX ]) prospectively followed up. If remained for initial 6 study, was stopped assessed at 1, 2, 3, 4, 6, 8 months....