A5086884134- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Systemic Sclerosis and Related Diseases
- Advanced Glycation End Products research
- Diet and metabolism studies
- Autoimmune and Inflammatory Disorders Research
- Diabetes Treatment and Management
- Adolescent and Pediatric Healthcare
- HER2/EGFR in Cancer Research
- Systemic Lupus Erythematosus Research
- Advanced Breast Cancer Therapies
- RNA and protein synthesis mechanisms
- Organ Transplantation Techniques and Outcomes
- Cell death mechanisms and regulation
- Breast Cancer Treatment Studies
- Cannabis and Cannabinoid Research
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Ion Transport and Channel Regulation
- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Antimicrobial Peptides and Activities
- Chronic Kidney Disease and Diabetes
- Metabolism and Genetic Disorders
- Diabetes and associated disorders
Victorian Cancer Biobank
2022-2023
Monash University
2009-2020
Baker Heart and Diabetes Institute
2013-2020
Florey Institute of Neuroscience and Mental Health
2017
The University of Melbourne
2017
Nationwide Children's Hospital
2005-2016
Cincinnati Children's Hospital Medical Center
2011
The Ohio State University
2008
National University of Ireland
2002
Cork University Hospital
2000-2002
Objective. Juvenile localized scleroderma (JLS) includes a number of conditions often grouped together. With the long-term goal developing uniform classification criteria, we studied epidemiological, clinical and immunological features children with JLS followed by paediatric rheumatology dermatology centres.
This study was undertaken to evaluate the long-term safety and effectiveness of etanercept alone or in combination with methotrexate (MTX) children selected categories juvenile idiopathic arthritis (JIA).Patients ages 2-18 years rheumatoid factor (RF)-positive RF-negative polyarthritis, systemic JIA, extended oligoarthritis were eligible for study. Patients received MTX (> =10 mg/m(2)/week [ approximately 0.3 mg/kg/week], maximum dosage 1 mg/kg/week), (0.8 mg/kg/week, dose 50 mg), plus 3 an...
Statins reduce atherosclerosis and cardiovascular morbidity in the general population, but their efficacy safety children adolescents with systemic lupus erythematosus (SLE) are unknown. This study was undertaken to determine 3-year of atorvastatin preventing subclinical progression pediatric-onset SLE.
Oxidative phosphorylation (OXPHOS) drives ATP production by mitochondria, which are dynamic organelles, constantly fusing and dividing to maintain kidney homoeostasis. In diabetic disease (DKD), mitochondria appear dysfunctional, but the temporal development of diabetes-induced adaptations in mitochondrial structure bioenergetics have not been previously documented. present study, we map changes dynamics function rat at 4, 8, 16 32 weeks diabetes. Our data reveal that precede albuminuria...
Approximately 80% of all breast cancers (BCs) are currently categorized as human epidermal growth factor receptor 2 (HER2)-negative [immunohistochemistry (IHC) 0, 1+, or 2+/in situ hybridization (ISH) negative]; approximately 60% BCs traditionally HER2-negative express low levels HER2. HER2-low (IHC 1+ IHC 2+/ISH-) status became clinically actionable with approval trastuzumab deruxtecan to treat unresectable/metastatic BC. Greater understanding patients disease is urgently needed.This...
<h3>Background:</h3> Most of the available documentation in literature on ocular involvement localised scleroderma (LS) are descriptions single cases adult patients. This article reports frequency and specific features a large cohort children with juvenile LS (JLS). <h3>Methods:</h3> Data from large, multi-centre, multinational study were used to collect analyse information involvement. <h3>Results:</h3> 24 out 750 patients (3.2%) revealed significant 16 female 8 male. (66.7%) had "en coup...
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein with dual roles in redox signaling and programmed cell death. Deficiency AIF known to result defective oxidative phosphorylation (OXPHOS), via loss of complex I activity assembly other tissues. Because the kidney relies on OXPHOS for metabolic homeostasis, we hypothesized that decrease would chronic disease (CKD). Here, report partial knockdown Aif mice recapitulates many features CKD, association compensatory increase ATP pool...
Genomic DNA containing the protein coding region for Drosophila cAMP-dependent kinase catalytic subunit has been cloned and sequenced. The probe used to detect isolate gene fragment was constructed from two partially complementary synthetic oligonucleotides contains 60 base pairs that encode (using codon preferences) amino acids 195-214 of beef heart subunit. In reduced stringency hybridization conditions, recognizes target sites in fly genomic with 85% homology. One these is gene, which...
Mitochondrial stress has been widely observed in diabetic kidney disease (DKD). Cyclophilin D (CypD) is a functional component of the mitochondrial permeability transition pore (mPTP) which allows exchange ions and solutes between matrix to induce swelling activation cell death pathways. CypD successfully targeted other contexts improve function reduced pathology. Two approaches were used elucidate role mPTP DKD. Firstly, mice with deletion gene encoding (Ppif-/-) rendered streptozotocin...
1087 Background: Approximately 50% of BCs traditionally categorized as HER2 negative (HER2-neg) express low levels (IHC 1+ or IHC 2+/ISH-; Miglietta, NPJ Breast Cancer 2021). HER2-targeted therapies for HER2-low metastatic BC (mBC) are under investigation (eg, T-DXd in the phase 3 DESTINY-Breast04 study; NCT03734029), but assays currently used to select patients (pts) approved anti-HER2 optimized high expression and not validated detection. A recent study found relatively poor agreement...
Objective This study evaluated the effects of obesity on health-related quality life (HRQOL) measures in juvenile-onset systemic lupus erythematosus (jSLE). Methods Obesity was defined as a body mass index (BMI) ≥95th percentile according to Sex-specific Center for Disease Control BMI-For-Age Charts and determined multicenter cohort jSLE patients. In this secondary analysis, domain summary scores Pediatric Quality Life (PedsQL) Inventory Child Health Questionnaire (CHQ) obese patients were...
Joint inflammation in juvenile rheumatoid arthritis (JRA) is sometimes associated with an autoimmune response to type II collagen (CII), a cartilage-specific protein. To test the hypothesis that down-regulation of autoimmunity CII can be accomplished JRA by oral administration CII, open-label study was performed 9 patients JRA.Seven factor-negative polyarticular disease and 2 pauciarticular (1 early onset 1 late onset) were treated for 3 months bovine CII. Patients examined activity...
Signaling via the receptor of advanced glycation end products (RAGE)—though complex and not fully elucidated in setting diabetes—is considered a key injurious pathway development diabetic nephropathy (DN). We report here that RAGE deletion resulted increased expression fibrotic markers (collagen I IV, fibronectin) inflammatory marker MCP-1 primary mouse mesangial cells (MCs) kidney cortex. RNA sequencing analysis MCs from RAGE−/− wild-type mice confirmed these observations. Nevertheless,...
We undertook this study to determine the quality, quantity, and temporal relationship of pep M5-induced cytokine release. The ability M5 stimulate interleukin-1 (IL-1) tumor necrosis factor alpha (TNF-alpha) production by a T-cell-depleted, monocyte- B-cell-enriched cell population was dependent on presence T cells. requirement for cells could be met addition exogenous gamma interferon (IFN-gamma). In IFN-gamma, induced release TNF-alpha, IL-1, IL-6, TNF-alpha levels peaked at 24 h, while...
Methylglyoxal, a by-product of glycolysis and precursor in the formation advanced glycation end-products, is significantly elevated diabetic myocardium. Therefore, we sought to investigate mitochondria-targeted methylglyoxal scavenger, MitoGamide, an experimental model spontaneous cardiomyopathy.Male 6-week-old Akita or wild type mice received daily oral gavage MitoGamide vehicle for 10 weeks. Several morphological systemic parameters were assessed, as well cardiac function by...