A5038117952- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Orthopaedic implants and arthroplasty
- Hydrocarbon exploration and reservoir analysis
- Neuroendocrine regulation and behavior
- Astro and Planetary Science
- Tendon Structure and Treatment
- Adipose Tissue and Metabolism
- Geology and Paleoclimatology Research
- Planetary Science and Exploration
- Hydraulic Fracturing and Reservoir Analysis
- Lower Extremity Biomechanics and Pathologies
- RNA Interference and Gene Delivery
- Orthopedic Infections and Treatments
- Regulation of Appetite and Obesity
- Total Knee Arthroplasty Outcomes
- Microfluidic and Capillary Electrophoresis Applications
- Chemical Reactions and Isotopes
- Bone Tissue Engineering Materials
- Fuel Cells and Related Materials
- Cardiac electrophysiology and arrhythmias
- Rabbits: Nutrition, Reproduction, Health
- Dendrimers and Hyperbranched Polymers
Christian Medical College & Hospital
2010-2024
Christian Medical College
2016-2024
Universidad de Zaragoza
2024
Institute for Stem Cell Biology and Regenerative Medicine
2024
AstraZeneca (United Kingdom)
2023
Creative Research Enterprises (United States)
2016
Southwestern Indian Polytechnic Institute
2003
University at Buffalo, State University of New York
1989
Cordis Automation (Netherlands)
1984
Marathon Oil (United States)
1977
Approximately 80% of all breast cancers (BCs) are currently categorized as human epidermal growth factor receptor 2 (HER2)-negative [immunohistochemistry (IHC) 0, 1+, or 2+/in situ hybridization (ISH) negative]; approximately 60% BCs traditionally HER2-negative express low levels HER2. HER2-low (IHC 1+ IHC 2+/ISH-) status became clinically actionable with approval trastuzumab deruxtecan to treat unresectable/metastatic BC. Greater understanding patients disease is urgently needed.This...
Chondroprogenitor cells (CPCs), recently identified as a distinct subpopulation, exhibit promise due to their mesenchymal properties, heightened chondrogenesis, and limited hypertrophic traits. The enrichment of progenitors is achieved through differential fibronectin adhesion migration-based explant assays, with Fibronectin Adhesion Assay-derived Chondroprogenitors (FAA-CPs) Migratory (MCPs) demonstrating superior potential compared chondrocytes. This article delves into the details...
Articular chondroprogenitors, a suitable contender for cell-based therapy in cartilage repair, routinely employ fetal bovine serum (FBS) expansion and differentiation. The possibility of transplant rejections or zoonoses transmissions raise need xeno-free alternatives. Use human platelet lysate (hPL), nutrient supplement abundant growth factors, has not been reported chondroprogenitor thus far. Our aim was to compare the biological profile chondroprogenitors grown hPL versus...
Cell-based therapy for articular hyaline cartilage regeneration predominantly involves the use of mesenchymal stem cells and chondrocytes. However, regenerated repair tissue is suboptimal due to formation mixed fibrocartilage, resulting in inferior long-term functional outcomes. Current preclinical research points towards potential cartilage-derived chondroprogenitors as a viable option healing. Fibronectin adhesion assay-derived (FAA-CP) migratory (MCP) exhibit features suitable...
The genetic basis for the spread of vancomycin resistance in Enterococcus faecium is largely unexplored India. present study aimed to investigate plasmid diversity and variation Tn1546 associated with vanA harbouring VREfm isolates.A total 122 isolates collected from blood cultures were included this study. MLST analysis was performed on all isolates, they also screened presence vanB genes. Whole genome sequencing a subset fifteen belonging ST1643.All carried gene. Twenty-four different...
Obtaining regeneration-competent cells and generating high-quality neocartilage are still challenges in articular cartilage tissue engineering. Although chondroprogenitor a resident subpopulation of native possess high capacity for proliferation formation, their potential regenerative medicine has not been adequately explored. Fetal cartilage, another source with greater cellularity higher cell-matrix ratio than adult tissue, evaluated sourcing to treat disorders. This study aimed compare...
Recent studies indicate that India is an endemic region for Burkholderia pseudomallei infection. We aimed to describe the clinical presentation of B. infection musculoskeletal system and summarise various treatment modalities used in our practice.Patients with confirmed microbiological diagnosis involving treated from January 2007 December 2016 a minimum follow-up 1 year were included. A retrospective review medical records was carried out patients' demographic data, co-morbidities,...
SUMMARY Freeze-etched preparations of rabbit neurohypophysis and isolated hormone granules from cow neurohypophyses were examined electron microscopically. Many features seen in conventionally prepared sections also apparent freeze-etched replicas, particularly the neurosecretory nerve-endings containing elementary elongated pituicyte processes. Measurements diameters both hormone-containing situ indicated that they slightly larger material than by conventional microscopic techniques....
Purpose: Cartilage repair following trauma or degeneration is poor, making cell-based therapy an important avenue of treatment. Chondrocytes and mesenchymal stem cells have been extensively studied as potential candidates, although tendency toward hypertrophy formation mixed hyaline-fibrocartilage necessitates further optimization. Chondroprogenitors, isolated using fibronectin adhesion assay are reported to show reduced enhanced chondrogenesis. Laminin, essential component extracellular...
Purpose Chondrocytes, isolated from articular cartilage, are routinely utilized in cell-based therapeutics for the treatment of cartilage pathologies. However, restoration biological tissue faces hindrance due to formation primarily fibrocartilaginous repair tissue. Chondroprogenitors have been reported display superiority terms their chondrogenic potential and lesser proclivity hypertrophy. In line with our recent results, comparing chondroprogenitors chondrocytes, we undertook isolation...
A new method of evoked response detection, previously demonstrated in the ventricle, has been studied atrium at time routine pacemaker implant 16 patients. The atrial was readily detectable all patients due to excellent recovery from poststimulus polarization. In six patients, as experimental threshold‐ tracking used automatically verify capture and generate strength‐duration curves. It is concluded that this pacing technique both simple reliable, automatic threshold feasible.
Objectives Bone-marrow mesenchymal stem cells (MSCs) and chondrocytes are currently used for cell-based therapy in cartilage repair. Chondroprogenitors (CPs), resident of articular cartilage, demonstrate likeness to cells. Reports suggest that phenotype is altered culture, thus making differentiation between the two cell populations difficult. Our objectives were electrophysiologically assess CPs, compare their mRNA expression with ionic channels already reported MSCs, observe effect time...
(1) Citrate ion in a concentration of 0.0416 M enhanced oxygen consumption rat, cat, dog, rabbit, guinea pig, and mouse brain slices brei dextrose Krebs-Ringer phosphate buffer. Optimal for was 0.0166 M. This effect noted also rat heart kidney. (2) Of the 7 Krebs-cycle intermediates used as substrates individually, only lactate maintained respiration better than did dextrose. (3) When possibility enhancement by other citrate tested, no ions reacted this way phosphate. (4) Phosphate played an...
Journal Article ‘NON-NEUROSECRETORY’ NERVE ENDINGS IN THE MAMMALIAN NEUROHYPOPHYSIS Get access K Lederis, Lederis M. R. C. Group for Research in Neurosecretion, Department of Pharmacology, University Bristol, 8, England Search other works by this author on: Oxford Academic Google Scholar A Livingston Acta Endocrinologica (Norway), Volume 56, Issue 1_Supplement, Dec 1967, Page S98, https://doi.org/10.1530/acta.0.056S098 Published: 01 December 1967
Chondrocytes and Mesenchymal Stem Cells (MSCs) are commonly used in cartilage repair therapies, but the regenerated tissue often contains an admixture of hyaline fibrocartilaginous tissue. Chondroprogenitor cells (CPCs), a subset resident cells, being investigated for their potential to produce hyaline-like However, identifying distinguishing markers chondroprogenitors remains challenging due similarity MSCs chondrogenic nature. Ghrelin, its receptor Growth Hormone Secretagogue Receptor...
The Oregon Basin field in northwestern Wyoming is about 9 mi (14.5 km) long and composed of a north dome south dome. Since its discovery 1927, over 122 million bbl oil have been produced from the Pennsylvanian Tensleep Sandstone at Basin. Geologists engineers worked together to describe reservoir accumulate data that would aid determining best methods for recovering this 50-year-old reservoir. Major variations are caused by erosion presence nonreservoir dolomite. Layers material separate...