Ivan Foeldvari
A5020603336- Autoimmune and Inflammatory Disorders Research
- Systemic Sclerosis and Related Diseases
- Adolescent and Pediatric Healthcare
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Lymphoblastic Leukemia research
- Inflammasome and immune disorders
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Dermatologic Treatments and Research
- Dermatological and Skeletal Disorders
- Rheumatoid Arthritis Research and Therapies
- Childhood Cancer Survivors' Quality of Life
- Inflammatory Myopathies and Dermatomyositis
- Immunodeficiency and Autoimmune Disorders
- Pharmaceutical studies and practices
- Mast cells and histamine
- Pulmonary Hypertension Research and Treatments
- Eosinophilic Disorders and Syndromes
- Kawasaki Disease and Coronary Complications
- Autoimmune Bullous Skin Diseases
- Skin Diseases and Diabetes
- Otitis Media and Relapsing Polychondritis
- Renal Diseases and Glomerulopathies
- Lymphoma Diagnosis and Treatment
- Child and Adolescent Health
Schön Klinik Hamburg Eilbek
2016-2025
Durham VA Medical Center
2022-2024
Kinderkrebs-Zentrum Hamburg
2015-2024
German Center for Pediatric and Adolescent Rheumatology
2018-2024
Asklepios
2015-2024
University of North Carolina at Chapel Hill
2022-2024
AID Atlanta
2024
American College of Rheumatology
2022-2024
Emory University
2022-2024
Convergence
2024
Tumor necrosis factor (TNF) has a pathogenic role in juvenile rheumatoid arthritis. We evaluated the efficacy and safety of adalimumab, fully human monoclonal anti-TNF antibody, children with polyarticular-course arthritis.Patients 4 to 17 years age active arthritis who had previously received treatment nonsteroidal antiinflammatory drugs underwent stratification according methotrexate use 24 mg adalimumab per square meter body-surface area (maximum dose, 40 mg) subcutaneously every other...
Objective. Juvenile localized scleroderma (JLS) includes a number of conditions often grouped together. With the long-term goal developing uniform classification criteria, we studied epidemiological, clinical and immunological features children with JLS followed by paediatric rheumatology dermatology centres.
The modified Rodnan skin score (mRSS) is a measure of thickness and used as primary or secondary outcome in clinical trials systemic sclerosis (scleroderma). This state-of-art review provides historical perspective the development mRSS, summarizes performance mRSS an measure, guidance on assessing makes recommendations for incorporation into trials.
Objective: Etanercept monotherapy has been studied and approved for treatment of polyarticular juvenile idiopathic arthritis (JIA). The following study evaluates the safety efficacy combination therapy etanercept methotrexate compared to in JIA. Methods: We perfomed an open, non-randomised on patients who had previously failed respond at least one disease-modifying antirheumatic drug (DMARD). A total 722 with JIA whom 1 item follow-up data was recorded were identified; these, 118 treated...
<h3>Context</h3>Novel therapies have improved the remission rate in chronic inflammatory disorders including juvenile idiopathic arthritis (JIA). Therefore, strategies of tapering therapy and reliable parameters for detecting subclinical inflammation now become challenging questions.<h3>Objectives</h3>To analyze whether longer methotrexate treatment during JIA prevents flares after withdrawal medication specific biomarkers identify patients at risk flares.<h3>Design, Setting,...
Abstract The term ‘sclerosing diseases of the skin' comprises specific dermatological entities, which have fibrotic changes skin in common. These mostly manifest different clinical subtypes according to cutaneous and extracutaneous involvement can sometimes be difficult distinguish from each other. present guideline focuses on characteristic histopathological features, diagnostic scores serum autoantibodies most useful for differential diagnosis. In addition, current strategies first‐...
In 2012, a European initiative called Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) was launched to optimise disseminate diagnostic management regimens children young adults with rheumatic diseases. Juvenile idiopathic arthritis (JIA) is the most common disease uveitis possibly its devastating extra-articular manifestation. Evidence-based guidelines are sparse mostly based on physicians' experience. Consequently, treatment practices differ widely, within between...
Objective. Systemic sclerosis (SSc) is a rare, heterogeneous disease, which affects different organs and therefore requires interdisciplinary diagnostic therapeutic management. To improve the detection follow-up of patients presenting with disease manifestations, an registry was founded contributions from subspecialties involved in care SSc.
Abstract Objective We previously documented that abatacept was effective and safe in patients with juvenile idiopathic arthritis (JIA) who had not achieved a satisfactory clinical response disease‐modifying antirheumatic drugs or tumor necrosis factor blockade. Here, we report results from the long‐term extension (LTE) phase of study. Methods This describes long‐term, open‐label double‐blind, randomized, controlled withdrawal trial 190 JIA ages 6–17 years. Children were treated 10 mg/kg...
To determine the clinical and immunologic features of systemic sclerosis (SSc) in a large group children describe evolution disease compare it with adult form.Data on 153 patients juvenile SSc collected from 55 pediatric rheumatology centers Europe, Asia, South North America were analyzed. Demographic, clinical, characteristics at onset, diagnosis, during course evaluated.Raynaud's phenomenon was most frequent symptom, followed by skin induration approximately 75% patients. Musculoskeletal...
Abstract Objective To develop criteria for the classification of systemic sclerosis (SSc) in children (juvenile SSc). Methods The study consisted 3 phases: 1) collection data on signs and symptoms actual patients with juvenile SSc that are useful defining involvement a particular organ; 2) selection parameters essential preparation set provisional (PCC) using 2 Delphi surveys; 3) consensus conference consisting steps: discussion rating clinical profiles 160 definite SSc, possible or other...
Abstract Introduction In the present study, we analysed in detail nuclear autoantibodies and their associations systemic sclerosis (SSc) patients included German Network for Systemic Scleroderma Registry. Methods Sera of 863 were according to a standardised protocol including immunofluorescence, immunoprecipitation, line immunoassay immunodiffusion. Results Antinuclear antibodies (ANA) detected 94.2% patients. 81.6%, at least one highly associated with SSc or overlap syndromes scleroderma...
To validate a core set of outcome measures for the evaluation response to treatment in patients with juvenile dermatomyositis (DM).In 2001, preliminary consensus-derived evaluating therapy DM was established. In present study, validated through an evidence-based, large-scale data collection that led enrollment 294 from 36 countries. Consecutive active disease were assessed at baseline and after 6 months. The validation procedures included assessment feasibility, responsiveness, discriminant...
<h3>Objective</h3> To assess the long-term efficacy and safety of infliximab plus methotrexate in juvenile rheumatoid arthritis (JRA). <h3>Methods</h3> Patients eligible for open-label extension (OLE, weeks 52–204) received 3–6 mg/kg every 8 methotrexate. <h3>Results</h3> Of 78/122 (64%) children entering OLE, 42 discontinued infliximab, most commonly due to consent withdrawal (11 patients), lack (eight patients) or patient/physician/sponsor requirement patients). Infliximab (mean dose 4.4...
Objective. To propose simple capillaroscopic definitions for interpretation of morphologies and to assess inter-rater reliability.
<h3>Abstract</h3> Antifungal resistance in pathogenic fungi is a growing global health concern. Non-pathogenic laboratory strains of <i>Saccharomyces cerevisiae</i> are useful model for studying mechanisms antifungal that relevant to understanding the same processes fungi. We developed series lab modules which high school students used experimental evolution study by isolating azole-resistant <i>S. and examining genetic basis resistance. All 99 sequenced clones from these experiments...
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and adolescents. Immunomodulatory drugs are used frequently its treatment. Using nominal group technique (NGT) Delphi method, we created a multidisciplinary, evidence- consensus-based treatment guideline for JIA based on systematic literature analysis three consensus conferences. Conferences were headed by professional moderator attended representatives who had been nominated their scientific societies or...