A5034332031- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Heart Rate Variability and Autonomic Control
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Cardiovascular Syncope and Autonomic Disorders
- Acute Ischemic Stroke Management
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Atherosclerosis and Cardiovascular Diseases
- Diabetes Management and Research
- Heart rate and cardiovascular health
- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Non-Invasive Vital Sign Monitoring
- Metabolism, Diabetes, and Cancer
- Menopause: Health Impacts and Treatments
- Lipid metabolism and disorders
- Genetic Associations and Epidemiology
- Cancer Risks and Factors
- Respiratory Support and Mechanisms
Columbia Southern University
2024
University of Oxford
2023
Wake Forest University
2012-2022
National Institutes of Health
2021-2022
Massachusetts General Hospital
2022
Vanderbilt University Medical Center
1999-2022
George Washington University
2022
Washington Center
2022
Prevention Group
2022
National Heart Lung and Blood Institute
1995-2021
There is no evidence from randomized trials to support a strategy of lowering systolic blood pressure below 135 140 mm Hg in persons with type 2 diabetes mellitus. We investigated whether therapy targeting normal (i.e., <120 Hg) reduces major cardiovascular events participants at high risk for events.
Background and Purpose This study was done to assess the relationship between prevalent cardiovascular disease arterial wall thickness in middle-aged US adults. Methods The association of preexisting coronary heart disease, cerebrovascular peripheral vascular with carotid popliteal intimal-medial (IMT) (measured by B-mode ultrasound) assessed 13 870 black white men women, aged 45 64, during Atherosclerosis Risk Communities (ARIC) Study baseline examination (1987 through 1989). Prevalent...
Atherosclerosis is often advanced before symptoms appear and it not clear whether treatment beneficial in middle-aged individuals with a low Framingham risk score (FRS) mild to moderate subclinical atherosclerosis.To assess statin therapy could slow progression and/or cause regression of carotid intima-media thickness (CIMT) over 2 years.Randomized, double-blind, placebo-controlled study (Measuring Effects on Intima-Media Thickness: an Evaluation Rosuvastatin [METEOR]) 984 individuals,...
OBJECTIVE Intensive therapy targeting normal blood glucose increased mortality compared with standard treatment in a randomized clinical trial of 10,251 participants type 2 diabetes at high-risk for cardiovascular disease (CVD) events. We evaluated whether the presence cardiac autonomic neuropathy (CAN) baseline modified effect intensive glycemia on outcomes Action to Control Cardiovascular Risk Diabetes (ACCORD) participants. RESEARCH DESIGN AND METHODS CAN was assessed by measures heart...
We investigated the demography and spatial pattern of an old-growth longleaf pine population using a large plot in which all trees at least 2 cm dbh were mapped tagged for individual recognition. The was uneven age size; tree size correlated positively with age. Large or old only loosely aggregated, forming background matrix that filled forest. In contrast, juvenile highly aggregated located areas low adult densities. Recruitment within this thus appears to occur primarily open spaces...
The resting ankle-brachial index (ABI) is a non-invasive method to assess the patency of lower extremity arterial system and screen for presence peripheral occlusive disease. To determine how ABI associated with clinical coronary heart disease (CHD), stroke, preclinical carotid plaque far wall intimal-medial thickness (IMT) popliteal arteries, we conducted analyses in 15 106 middle-aged adults from baseline examination (1987–1989) Atherosclerosis Risk Communities (ARIC) Study. prevalence...
Dysregulation of the autonomic nervous system has been implicated in development hypertension. Heart rate variability is a noninvasive tool to quantitatively estimate cardiac activity and used document decreased The ability heart predict incident hypertension not well studied, there are no studies whether leads changes variability. We investigated temporal sequence linking hypertension, blood pressure, population-based cohort 11 061 individuals aged 45 54 years at baseline. Individuals with...
Carotid intima-media thickness (CIMT) measurements are currently widely used in randomized controlled trials (RCTs) to study the efficacy of interventions. In designing a RCT with CIMT as primary outcome, several ultrasound options may be considered. We discuss various and provide pooled estimate progression. addition, we quantify effect these choices on sample size for RCT.To average progression rate, performed analysis using rates control groups from published RCTs. The pros cons following...
In a previously reported randomized trial of standard and intensive systolic blood-pressure control, data on some outcome events had yet to be adjudicated post-trial follow-up not been collected.
To compare effects of combinations standard and intensive treatment glycemia either blood pressure (BP) or lipids in the Action to Control Cardiovascular Risk Diabetes (ACCORD) trial.
Recent publications have stated that the blood pressure (BP) measurement technique used in SPRINT (Systolic Blood Pressure Intervention Trial) was unattended. However, protocol does not address issue of attendance. A survey conducted immediately after closeout visits were completed to inquire whether BP measurements usually attended or unattended by staff. There 4082 participants at 38 sites measured leaving participant alone entire time (always alone), 2247 25 had personnel room (never 1746...
Intima-media thickness of the common carotid arteries is a marker atherosclerosis and has been shown to be associated with prevalent incident coronary heart disease risk factors. The authors examined association baseline factors or change in intima-media over follow-up (1987-1998) Atherosclerosis Risk Communities (ARIC) population-based cohort (baseline: age 45-64 years, n = 15,792). Subjects were members households sampled four areas United States. Either not adjusting for doing so...
The objective of this study was to test prospectively in a population sample whether individuals with impaired heart rate variability (HRV) are at increased risk developing coronary disease (CHD) and non-CHD mortality relationship is more pronounced among diabetes. We examined the association between HRV incident CHD cohort 11,654 men women aged 45-64 years intake, from biracial, population-based Atherosclerosis Risk Communities Study. Supine, resting, 2-min beat-to-beat data were collected...
OBJECTIVE—To describe the progression of autonomic impairment among individuals with diabetes and pre-diabetic metabolic impairments. RESEARCH DESIGN AND METHODS—We investigated consequence impairments on 9-year change in heart rate variability (HRV) a population-based cohort 6,245 aged 45–64 years at baseline cross-sectional associations 9,940 individuals. RESULTS—Diabetic subjects had more rapid temporal decrease HRV conditional than nondiabetic subjects. Adjusted mean annual changes (95%...
Serum uric acid has been positively associated with incident hypertension, but previous studies have had limited ability to explore this relationship across sex and ethnic strata. We sought evaluate association in a biethnic cohort of middle-aged men women. Participants the Atherosclerosis Risk Communities (ARIC) study who were free hypertension at baseline (N=9104) evaluated for 3-year intervals over 4 examinations. Adjusted Cox proportional hazards models risk or progression blood category...
OBJECTIVE To test at the population level whether people with multiple metabolic syndrome (MMS) disorders have reduced cardiac autonomic activity (CAA). RESEARCH DESIGN AND METHODS We examined association between of CAA and MMS disorders, degree clustering segregate combination levels, using a random sample 2,359 men women aged 45–64 years from biracial, population-based Atherosclerosis Risk in Communities (AR1C) Study. Supine resting 2-min beat-to-beat heart rate data were collected....
The Atherosclerosis Risk in Communities Study is a prospective investigation of the etiology and natural history atherosclerosis clinical disease four US communities.Noninvasive ultrasonic methods were used to determine mean wall thickness (WT), radius (R), circumferential arterial strain (CAS) left common carotid artery 3,321 white male female study participants between ages 45 64 years. standard deviation Young's elastic modulus (Y) 5-year age groups determined for each sex by combining...
Statins reduce atherosclerosis and cardiovascular morbidity in the general population, but their efficacy safety children adolescents with systemic lupus erythematosus (SLE) are unknown. This study was undertaken to determine 3-year of atorvastatin preventing subclinical progression pediatric-onset SLE.
To evaluate risk factors for subclinical atherosclerosis in a population of patients with pediatric systemic lupus erythematosus (SLE).In prospective multicenter study, cohort 221 underwent baseline measurements carotid intima-media thickness (CIMT) as part the Atherosclerosis Prevention Pediatric Lupus Erythematosus (APPLE) trial. SLE disease measures, medications, and traditional were assessed. A standardized protocol was used to assess bilateral common arteries mean maximal IMT 12...