A5019535453- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Blood Pressure and Hypertension Studies
- Frailty in Older Adults
- Advanced Neuroimaging Techniques and Applications
- Bioinformatics and Genomic Networks
- Health Systems, Economic Evaluations, Quality of Life
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Health, Environment, Cognitive Aging
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Physical Activity and Health
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Brain Tumor Detection and Classification
- Health and Well-being Studies
- Machine Learning in Bioinformatics
- Chronic Kidney Disease and Diabetes
- Cancer-related cognitive impairment studies
- Health disparities and outcomes
- Cholinesterase and Neurodegenerative Diseases
- Ginkgo biloba and Cashew Applications
- Acute Ischemic Stroke Management
Wake Forest University
2015-2024
University of California, San Francisco
2006-2024
Alzheimer’s Disease Neuroimaging Initiative
2023-2024
San Francisco VA Medical Center
2024
National Institutes of Health
2009-2021
University of Tennessee Health Science Center
2021
Case Western Reserve University
2016-2021
University of Alabama at Birmingham
2016-2021
National Heart Lung and Blood Institute
2021
Sprint (United States)
2021
In older adults reduced mobility is common and an independent risk factor for morbidity, hospitalization, disability, mortality. Limited evidence suggests that physical activity may help prevent disability; however, there are no definitive clinical trials examining whether prevents or delays disability.To test the hypothesis a long-term structured program more effective than health education (also referred to as successful aging program) in reducing of major disability.The Lifestyle...
<h3>Importance</h3> The appropriate treatment target for systolic blood pressure (SBP) in older patients with hypertension remains uncertain. <h3>Objective</h3> To evaluate the effects of intensive (<120 mm Hg) compared standard (<140 SBP targets persons aged 75 years or but without diabetes. <h3>Design, Setting, and Participants</h3> A multicenter, randomized clinical trial who participated Systolic Blood Pressure Intervention Trial (SPRINT). Recruitment began on October 20, 2010,...
There are currently no proven treatments to reduce the risk of mild cognitive impairment and dementia.To evaluate effect intensive blood pressure control on dementia.Randomized clinical trial conducted at 102 sites in United States Puerto Rico among adults aged 50 years or older with hypertension but without diabetes history stroke. Randomization began November 8, 2010. The was stopped early for benefit its primary outcome (a composite cardiovascular events) all-cause mortality August 20,...
Background: High blood pressure is an important public health concern because it highly prevalent and a risk factor for adverse outcomes, including coronary heart disease, stroke, decompensated failure, chronic kidney decline in cognitive function. Observational studies show progressive increase associated with above 115/75 mm Hg. Prior research has shown that reducing elevated systolic lowers the of subsequent clinical complications from cardiovascular disease. However, optimal to reduce...
<h3>Importance</h3> Epidemiological evidence suggests that physical activity benefits cognition, but results from randomized trials are limited and mixed. <h3>Objective</h3> To determine whether a 24-month program in better cognitive function, lower risk of mild impairment (MCI) or dementia, both, compared with health education program. <h3>Design, Setting, Participants</h3> A clinical trial, the Lifestyle Interventions Independence for Elders (LIFE) study, enrolled 1635 community-living...
The effect of intensive blood pressure lowering on brain health remains uncertain.To evaluate the association treatment with cerebral white matter lesion and volumes.A substudy a multicenter randomized clinical trial hypertensive adults 50 years or older without history diabetes stroke at 27 sites in United States. Randomization began November 8, 2010. overall was stopped early because benefit for its primary outcome (a composite cardiovascular events) all-cause mortality August 20, 2015....
The appropriate target for BP in patients with CKD and hypertension remains uncertain. We report prespecified subgroup analyses of outcomes participants baseline the Systolic Blood Pressure Intervention Trial. randomly assigned to a systolic <120 mm Hg (intensive group; n =1330) or <140 (standard =1316). After median follow-up 3.3 years, primary composite cardiovascular outcome occurred 112 intensive group 131 standard (hazard ratio [HR], 0.81; 95% confidence interval [95% CI], 0.63...
In a previously reported randomized trial of standard and intensive systolic blood-pressure control, data on some outcome events had yet to be adjudicated post-trial follow-up not been collected.
Substantial heterogeneity and uncertainty exist in the observed associations between alcohol consumption dementia.To assess association dementia roles of mild cognitive impairment (MCI) apolipoprotein E ε4 (APOE E4) genotype modifying this association.This cohort study used data from Ginkgo Evaluation Memory Study, conducted 2000 to 2008 among US community-dwelling participants. This analyzed 3021 participants aged 72 years older who were free dementia. Data analysis was performed 2017...
Importance Alzheimer disease (AD), a neurodegenerative characterized by β-amyloid plaques and τ tangles in the brain, represents an unmet medical need with no fully approved therapeutics to modify progression. Objective To investigate safety efficacy of crenezumab, humanized monoclonal immunoglobulin G4 antibody targeting oligomers, participants prodromal mild (early) AD. Design, Setting, Participants Two phase 3 multicenter randomized double-blind placebo-controlled parallel-group studies...
Background: Hypertension (HTN) is a risk factor for dementia, and animal studies suggest that centrally active angiotensin-converting enzyme (ACE) inhibitors (those cross the blood-brain barrier) may protect against dementia beyond HTN control.Methods: Participants in Cardiovascular Health Study Cognition Substudy with treated no diagnosis of congestive heart failure (n=1054; mean age, 75 years) were followed up median 6 years to determine whether cumulative exposure ACE (as class by central...
The aim of this study was to determine whether use diuretics, angiotensin-1 receptor blockers (ARB), angiotensin-converting enzyme inhibitors (ACE-I), calcium channel (CCB), or β-blockers (BB) associated with a reduced risk Alzheimer disease (AD) dementia in participants normal cognition mild cognitive impairment (MCI).Secondary longitudinal data analysis the Ginkgo Evaluation Memory Study older adults at least 75 years age (n = 1,928) MCI 320) over median 6.1-year period using Cox...
The Systolic Blood Pressure Intervention Trial (SPRINT) is testing whether a lower systolic blood pressure (BP) target of 120mm Hg leads to reduction in cardiovascular morbidity and mortality among hypertensive, nondiabetic adults. Because there may be detrimental effects intensive BP control, particularly older, frail adults, we sought characterize frailty within SPRINT address ongoing questions about the ability large-scale trials enroll representative samples noninstitutionalized,...
OBJECTIVES: To determine the cognitive and functional consequences of dual use cholinesterase inhibitors (ChIs) bladder anticholinergics oxybutynin or tolterodine. DESIGN: Prospective cohort study. SETTING: Nursing homes (NHs) in state Indiana. PARTICIPANTS: Three thousand five hundred thirty‐six Medicaid‐eligible NH residents aged 65 older taking a ChI between January 1, 2003, December 31, 2004. Residents were excluded if they an anticholinergic other than MEASUREMENTS: Indiana Medicaid...
Cognitive function and physical performance are associated, but the common sequence of cognitive decline remains unclear. In Women's Health Initiative Memory Study (WHIMS) clinical trial, we examined associations at baseline over a 6-year follow-up period between Modified Mini-Mental State (3MS) Examination three measures (PPMs): gait speed (meters/second), chair stands (number in 15 seconds), grip strength (kilograms). Using mixed models, 3MS as predictor change PPM, PPM predictors change....
[Correction Notice: An erratum for this article was reported in Vol 26(2) of Psychology and Aging (see record 2011-05802-001). This contains an error the Discussion, under Implications, Caveats, Future Directions heading. The third paragraph includes sentences that should have been removed. corrected appears correction.] We conducted secondary analyses to determine relationship between longstanding personality traits risk Alzheimer's disease (AD) among 767 participants 72 years age or older...
The efficacy of non-pharmacological intervention approaches such as physical activity, strength, and cognitive training for improving brain health has not been established. Before definitive trials are mounted, important design questions on participation/adherence, interventions effects must be answered to more fully inform a full-scale trial.SHARP-P was single-blinded randomized controlled pilot trial 4-month activity (PA) and/or (CT) in 2 × factorial with education control condition 73...
The goal of this work is to introduce new metrics assess risk Alzheimer's disease (AD) which we call AD Pattern Similarity (AD-PS) scores. These are the conditional probabilities modeled by large-scale regularized logistic regression. AD-PS scores derived from structural MRI and cognitive test data were tested across different situations using Disease Neuroimaging Initiative (ADNI) study. computed groups participants stratified status, age functional status. Cox proportional hazards...
Background and Purpose— Arterial stiffness is a measure of subclinical cardiovascular disease increases with age. This study examines the association between arterial cognitive decline in cohort older adults. Methods— A total 2488 subjects baseline (mean age, 74.2 years; 52.3% women) were prospectively followed over 9 years Health, Aging, Body Composition Study. was measured as pulse wave velocity (PWV) analyzed tertiles. Cognitive function assessed using Modified Mini-Mental State...
<b>Objective</b> To test whether a long term, structured physical activity program compared with health education reduces the risk of serious fall injuries among sedentary older people functional limitations. <b>Design</b> Multicenter, single blinded randomized trial (Lifestyle Interventions and Independence for Elders (LIFE) study). <b>Setting</b> Eight centers across United States, February 2010 to December 2011. <b>Participants</b> 1635 adults aged 70-89 years...