A5086431899- Dementia and Cognitive Impairment Research
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Blood Pressure and Hypertension Studies
- Lung Cancer Research Studies
- Meningioma and schwannoma management
- Trigeminal Neuralgia and Treatments
- Advanced Radiotherapy Techniques
- Bladder and Urothelial Cancer Treatments
- Retinal Diseases and Treatments
- Vitamin D Research Studies
- Facial Nerve Paralysis Treatment and Research
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Diet and metabolism studies
- Management of metastatic bone disease
- Parathyroid Disorders and Treatments
- Intensive Care Unit Cognitive Disorders
- Frailty in Older Adults
- Childhood Cancer Survivors' Quality of Life
- Cardiovascular Disease and Adiposity
- Healthcare cost, quality, practices
- Esophageal Cancer Research and Treatment
Wake Forest University
2014-2023
University of Alabama at Birmingham
2022
Atrium Health Wake Forest Baptist
2004-2021
Sprint (United States)
2021
SPRINT
2021
Winston-Salem State University
2019
Duke University
2017
University of Kentucky
2016
University of Mississippi Medical Center
2013
Johns Hopkins University
2002-2009
Physical rehabilitation in the intensive care unit (ICU) may improve outcomes of patients with acute respiratory failure.To compare standardized therapy (SRT) to usual ICU failure.Single-center, randomized clinical trial at Wake Forest Baptist Medical Center, North Carolina. Adult (mean age, 58 years; women, 55%) admitted failure requiring mechanical ventilation were SRT (n=150) or from October 2009 through May 2014 6-month follow-up.Patients group received daily until hospital discharge,...
A prospective, open-label phase II study was conducted to determine whether donepezil, a US Food and Drug Administration-approved reversible acetylcholinesterase inhibitor used treat mild moderate Alzheimer's type dementia, improved cognitive functioning, mood, quality of life (QOL) in irradiated brain tumor patients.Thirty-four patients received donepezil 5 mg/d for 6 weeks, then 10 18 followed by washout period weeks off drug. Outcomes were assessed at baseline, 12, 24 (end treatment), 30...
Nonhormonal treatment options have been investigated as treatments for hot flashes, a major clinical problem in many women. Starting 2000, series of 10 individual double-blind placebo-controlled studies has evaluated newer antidepressants and gabapentin treating flashes. This current project was developed to conduct an patient pooled analysis the data from these published trials.
<h3>Importance</h3> Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and white matter lesions the brain. Poor control of blood pressure (BP) lipid levels factors T2DM-related decline, but effect intensive treatment on function structure is unknown. <h3>Objective</h3> To examine whether therapy hypertension combination a statin plus fibrate reduces total volume (TBV) patients T2DM. <h3>Design, Setting,...
In Brief Objective: To evaluate the utility of 18F-FDG-PET in predicting response to concomitant chemoradiation locally-advanced esophageal cancer. Summary Background Data: Approximately 25% cancer patients experience a pathologic complete (pCR) preoperative therapy. Computed tomography, endoscopy, and endoscopic ultrasound are unable identify experiencing pCR. Growing evidence supports use staging its ability detect occult metastatic lymph nodal disease. The identification with pCR could...
We observed the relief of hot flashes in breast cancer survivors taking tamoxifen and treated with sertraline for depression. Our objective was to assess effect on frequency severity flashes, mood status, health-related quality life. used a randomized, double-blind, placebo-controlled, crossover study using 6 weeks (50 mg each morning) versus placebo. Study participants were 62 from an oncology clinic tertiary care center adjuvant reporting bothersome flashes. Patients asked keep daily flash...
Cognitive function and physical performance are associated, but the common sequence of cognitive decline remains unclear. In Women's Health Initiative Memory Study (WHIMS) clinical trial, we examined associations at baseline over a 6-year follow-up period between Modified Mini-Mental State (3MS) Examination three measures (PPMs): gait speed (meters/second), chair stands (number in 15 seconds), grip strength (kilograms). Using mixed models, 3MS as predictor change PPM, PPM predictors change....
This study aimed to determine the association between non-high-fat diet-induced obesity- (non-DIO-) associated gut microbiome dysbiosis with abnormalities like cellular turnover of intestinal cells, tight junctions, and mucin formation that can impact permeability. We used leptin-deficient (Lepob/ob) mice in comparison C57BL/6J control mice, which are fed on identical diets, performed comparative correlative analyses composition, permeability, structural changes, junction-mucin formation,...
Transbronchial needle aspiration has emerged as a key technique for sampling mediastinal adenopathy but variable yields are reported. To determine the number of aspirates needed to optimize yield, we prospectively studied transbronchial and sequential effect each successive specimen on diagnostic yield in 79 patients with known or suspected lung carcinoma adenopathy. A total 451 were performed (mean, 5.7 per patient; range, 2-13) 45 cases (57%) positive malignancy. cytologically occurred...
Gamma Knife surgery (GKS) has been reported as an effective modality for treating brain metastases from renal cell carcinoma (RCC). The authors aimed to determine if targeted agents such tyrosine kinase inhibitors, mammalian target of rapamycin and bevacizumab affect the patterns failure RCC after GKS.Between 1999 2010, 61 patients with were treated GKS. A median dose 20 Gy (range 13-24 Gy) was prescribed margin each metastasis. Kaplan-Meier analysis used local control, distant failure,...
OBJECTIVE Longitudinal evidence linking diabetic retinopathy with changes in brain structure and cognition is sparse. We used data from the Action to Control Cardiovascular Risk Diabetes (ACCORD) trial determine whether at baseline predicted or 40 months later. RESEARCH DESIGN AND METHODS Participants ACCORD-MIND ACCORD-Eye substudies were included analyses of (n = 1,862) MRI-derived variables 432). Retinopathy was categorized as none, mild nonproliferative, moderate/severe. Tests...
Survivorship from critical illness has improved; however, factors mediating the functional recovery of persons experiencing a remain incompletely understood.To identify groups acute respiratory failure (ARF) survivors with similar patterns physical function after discharge and to determine characteristics associated group membership in each trajectory group.We performed secondary analysis randomized controlled trial, using group-based modeling distinct subgroups patients ARF. Chi-square...
Meta-analyses of randomized clinical trials have indicated that improved hypertension control reduces the risk for cognitive impairment and dementia. However, it is unclear to what extent pathways reflective Alzheimer disease (AD) pathology are affected by control.To evaluate association intensive blood pressure on AD-related brain biomarkers.This a substudy Systolic Blood Pressure Intervention Trial (SPRINT MIND), multicenter trial compared efficacy 2 different pressure-lowering strategies....
Objectives To examine the relationship between 25‐hydroxyvitamin D (25( OH )D) levels and cognitive performance over time in older adults Health, Aging Body Composition (Health ABC ) Study. Design Prospective cohort study. Setting Community‐dwelling participants P ittsburgh, ennsylvania, M emphis, T ennessee. Participants Well‐functioning aged 70 to 79 at baseline with serum 25( )D measured 12‐month follow‐up visit function 4‐year (N = 2,777). Measurements Vitamin status was categorized as...
OBJECTIVE Understanding the effect of diabetes as well alternative treatment strategies on cerebral structure is critical for development targeted interventions against accelerated neurodegeneration in type 2 diabetes. We investigated whether characteristics were associated with spatially specific patterns brain changes and those affected by intensive versus standard glycemic treatment. RESEARCH DESIGN AND METHODS Using baseline MRIs 488 participants from Action to Control Cardiovascular...
Abstract Purpose: We assessed the safety and efficacy of vitamin D analogue, 19-nor-1α-25-dihydroxyvitamin D2 (paricalcitol), in patients with androgen-independent prostate cancer. Experimental Design: Patients received paricalcitol i.v. three times per week on an escalating dose 5 to 25 μg (3-15 μg/m2). The primary end point was prostate-specific antigen (PSA) response. Secondary points were characterization toxicity this population, changes serum parathyroid hormone (PTH), survival....