A5008718884- Vitamin D Research Studies
- Bone health and osteoporosis research
- Estrogen and related hormone effects
- Bone health and treatments
- Prostate Cancer Treatment and Research
- Cancer Risks and Factors
- Radiation Dose and Imaging
- Radioactivity and Radon Measurements
- Nutritional Studies and Diet
- Effects and risks of endocrine disrupting chemicals
- Parathyroid Disorders and Treatments
- Air Quality and Health Impacts
- Ovarian cancer diagnosis and treatment
- Climate Change and Health Impacts
- Neuroendocrine Tumor Research Advances
- Carcinogens and Genotoxicity Assessment
- Sexual Differentiation and Disorders
- Vitamin C and Antioxidants Research
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Nutrition, Genetics, and Disease
- Effects of Radiation Exposure
- Risk Perception and Management
- Amyotrophic Lateral Sclerosis Research
- Neuroblastoma Research and Treatments
Wake Forest University
2007-2024
University of North Carolina at Chapel Hill
1990-2024
University of North Dakota
2015-2024
Brown University
2024
Patel Hospital
2024
Mountain Area Health Education Center
2024
United States Department of the Interior
2024
United States Geological Survey
2024
Brigham and Women's Hospital
2024
Harvard University
2024
Background. Prostate cancer is the most prevalent nonskin among men in United States and second leading cause of deaths men, The prostate remains obscure. Recently it was hypothesized that low levels vitamin D, a hormone with potent antitumor properties, may increase risk for clinical cancer. Methods. Because major source D casual exposure to ultraviolet (UV) radiation, authors examined geographic distributions UV radiation mortality 3073 counties contiguous using linear regression trend...
Vitamin D status has been hypothesized to play a role in musculoskeletal function. Using data from the InCHIANTI study, we examined association between vitamin and physical performance.A representative sample of 976 persons aged 65 years or older at study baseline were included. Physical performance was assessed using short battery (SPPB) handgrip strength. Multiple linear regression used examine (serum 25OHD), parathyroid hormone (PTH), adjusting for sociodemographic variables, behavioral...
Prostate cancer continues to be a major health threat, especially among African American men. The Selenium and Vitamin E Cancer Prevention Trial (SELECT), which opened on July 25, 2001, was planned study possible agents for the prevention of prostate in population 32,400 men United States, including Puerto Rico, Canada. SELECT is phase III randomized, placebo-controlled trial selenium (200 microg/day from L-selenomethionine) and/or vitamin (400 IU/day all rac alpha-tocopheryl acetate)...
Abstract Purpose This ecological analysis investigates the spatial patterns of COVID‐19 epidemic in United States relation to socioeconomic variables that characterize US counties. Methods Data on confirmed cases and deaths from for 2,814 counties were obtained Johns Hopkins University. We used Geographic Information Systems (GIS) map aspects this pandemic investigate disparities between metropolitan nonmetropolitan communities. Multiple regression models explore contextual risk factors...
OBJECTIVE—Increasing rates of type 2 diabetes worldwide suggest that may be caused by environmental toxins. Cadmium is a widespread pollutant accumulates in the pancreas and exerts diabetogenic effects animals. To test hypothesis exposure to cadmium associated with impaired fasting glucose diabetes, we examined associations between urinary prevalence (prediabetes) Third National Health Nutrition Examination Survey (NHANES III). RESEARCH DESIGN AND METHODS—We analyzed data on 8,722 adults ≥40...
Abstract Substantial experimental evidence indicates that the hormonal form of vitamin D promotes differentiation and inhibits proliferation, invasiveness, metastasis human prostatic cancer cells. Results from epidemiologic studies status and/or receptor (VDR) polymorphisms prostate risk have been mixed. We conducted a population-based, case-control study advanced among men ages 40 to 79 years San Francisco Bay area. Interview data on lifetime sun exposure other factors were collected for...
We investigated the association between serum levels of 25-hydroxyvitamin D (25-OHD) and risk death in Norwegian cancer patients. The study population was 658 patients with cancers breast (n = 251), colon 52), lung 210), lymphoma 145), obtained from JANUS, a population-based bank Norway. Serum samples were collected within 90 days diagnosis analyzed for 25-OHD. Patients diagnosed during 1984–2004 followed throughout 2008. used Cox regression models to assess relationship 25-OHD death. Three...
This study assessed the safety, tolerability, pharmacokinetics and pharmacodynamics of first-in-class dual mammalian target rapamycin complex (mTORC)1/mTORC2 inhibitor, AZD8055. Patients with advanced solid malignancies or lymphomas were recruited into this phase I, open-label, dose-escalation AZD8055 starting at 10 mg twice-daily oral dosing (BID). Forty-nine patients received Dose-limiting toxicities reported 40 (n=1), 90 (n=1) 120 (n=3) BID; all grade 3 rises in transaminases, reversible...
Epidemiologic and experimental data support a role for 1,25-dihydroxyvitamin D(3) in the growth regulation of prostate cancer. We conducted phase II clinical trial evaluating calcitriol (1,25(OH)(2)D(3)) patients with hormone refractory enrolled 14 this study. 1,25(OH)(2)D(3) was initiated at daily oral dose 0.5 μg escalated to 1.5 daily. No objective responses were observed. However, two decreases 25% 45% specific antigen levels seen. Hypercalcemia predominant toxicity. conclude that given...
Sunlight is essential for the production of vitamin D in body. Evidence exists to suggest that metabolites may have a role tumor growth suppression. In this large study, involving over million cancer patients from United Kingdom, we analyzed season diagnosis and sunlight exposure survival cancers breast, colorectum, lung, prostate at all sites combined. We used population-based data Thames Cancer Registry analyze periods 0-1 0-5 years after diagnosis. The analysis was performed using Cox...
Considerable evidence indicates that vitamin D may reduce the risk of several cancers, including breast cancer. This study examined associations cancer with sun exposure, principal source D, and receptor gene (VDR) polymorphisms (FokI, TaqI, BglI) in a population-based case-control Hispanic, African-American, non-Hispanic White women aged 35–79 years from San Francisco Bay Area California (1995–2003). In-person interviews were obtained for 1,788 newly diagnosed cases 2,129 controls. Skin...
Prostate cancer cell lines exhibit variable growth suppression by the hormonal form of vitamin D3, 1,25-Dihydroxyvitamin D3 [1,25 (OH)2D] (1,25 D3). To understand molecular basis for this differential sensitivity to 1,25 we compared response d3, D receptor (VDR) content and VDR transcriptional activity in four well-characterized human prostate lines: LNCaP, DU145, PC-3 ALVA-31. In DU145 cells, relative lack inhibition (< 10% inhibition) correlates with very low levels (9-15 fmol/mg protein)...
Mounting experimental and epidemiologic evidence supports the hypothesis that vitamin D reduces risk of prostate cancer. Some suggests cancer may be influenced by sun exposure early in life. We analyzed data from National Health Nutrition Examination Survey I Epidemiologic Follow-up Study to examine associations with early-life adult residential exposures were assessed through self-report, physician report, dermatologic examination. used solar radiation state birth as a measure 1971 1975...