A5028492706- Bladder and Urothelial Cancer Treatments
- Gene expression and cancer classification
- Urinary Bladder and Prostate Research
- Estrogen and related hormone effects
- Occupational and environmental lung diseases
- Molecular Biology Techniques and Applications
- Bioinformatics and Genomic Networks
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Medical Imaging and Pathology Studies
- Biomedical Text Mining and Ontologies
- Erythrocyte Function and Pathophysiology
- Nuclear Structure and Function
- Vitamin D Research Studies
- Glycosylation and Glycoproteins Research
- Prostate Cancer Treatment and Research
- Sarcoma Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Fibroblast Growth Factor Research
University of Pittsburgh
2011-2024
UPMC Hillman Cancer Center
1995-2019
University of Pittsburgh Medical Center
1994-2019
University of Pennsylvania
2016
Roswell Park Comprehensive Cancer Center
2007
Shadyside Hospital
2000
Institute for Medical Informatics and Biostatistics
2000
University of Iowa
1994-1998
University of Bristol
1996
Washington University in St. Louis
1989-1995
Abstract Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining chest cavity. To expand our understanding MPM, we conducted comprehensive integrated genomic study, including most detailed analysis BAP1 alterations to date. We identified histology-independent molecular prognostic subsets, and defined novel subtype with TP53 SETDB1 mutations extensive loss heterozygosity. also report strong expression immune-checkpoint gene VISTA in epithelioid strikingly higher than...
No AccessJournal of Urology1 May 1992The Relative Proportion Stromal and Epithelial Hyperplasia is Related to the Development Symptomatic Benign Prostate Ellen Shapiro, Michael J. Becich, Victor Hartanto, Herbert Lepor ShapiroEllen Shapiro , BecichMichael Becich HartantoVictor Hartanto LeporHerbert View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37546-8AboutPDF ToolsAdd favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The...
Cardiac fibroblasts impact myocardial development and remodeling through intercellular contact with cardiomyocytes, but less is known about noncontact, profibrotic signals whereby alter cardiomyocyte behavior. Fibroblasts cardiomyocytes were harvested from newborn rat ventricles separated by serial digestion gradient centrifugation. Cardiomyocytes cultured in 1) standard medium, 2) medium diluted 1:1 PBS, or 3) conditioned > =72 h cardiac fibroblasts. Serum concentrations held constant under...
Myelodysplasia represents the most common cause of neurogenic bladder dysfunction in children. The specific histological features associated with myelodysplastic bladders have not been previously characterized. Our objective was to study relationship between smooth muscle and connective tissue control using classical morphometric analysis assistance an automated image system. Gross specimens normal stillborn fetuses showed organized bundles embedded a small amount tissue. myelomeningocele...
Section:ChooseTop of pageAbstract <<Overview SarcoidosisOverview the Lung Micr...Rationale for GRADS S...Clinical Outcome MeasuresStudy Procedures and Samp...Study AnalysesStudy PotentialConclusionsReferencesCITING ARTICLES
Background Sarcoidosis is a multisystem granulomatous disease of unknown origin with variable and often unpredictable course pattern organ involvement. In this study we sought to identify specific bronchoalveolar lavage (BAL) cell gene expression patterns indicative distinct phenotypic traits. Methods RNA sequencing by Ion Torrent Proton was performed on BAL cells obtained from 215 well-characterised patients pulmonary sarcoidosis enrolled in the multicentre Genomic Research Alpha-1...
Abstract The multifaceted nature of multiple sclerosis requires quantitative biomarkers that can provide insights related to diverse physiological pathways. To this end, proteomic analysis deeply-phenotyped serum samples, biological pathway modeling, and network were performed elucidate inflammatory neurodegenerative processes, identifying sensitive disease activity. Here, we evaluated the concentrations > 1400 proteins in 630 samples from three cohorts for association with clinical...
A prototype, content-based image retrieval system has been built employing a client/server architecture to access supercomputing power from the physician's desktop. The retrieves images and their associated annotations networked microscopic pathology database based on content similarity user supplied query images. Similarity is evaluated four feature types: color histogram, texture, Fourier coefficients, wavelet using vector dot product as distance metric. Current accuracy varies across...
No AccessJournal of Urology1 Jun 1991Internalization Bacille Calmette-Guerin by Bladder Tumor Cells Michael J. Becich, Shirley Carroll, and Timothy L. Ratliff BecichMichael Becich , CarrollShirley Carroll RatliffTimothy View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)38622-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Mechanisms which intravesical bacille (BCG) treatment mediates antitumor activity are...
We evaluated the prognostic value of purified protein derivative skin test reactivity and a granulomatous response in intravesical bacillus Calmette-Guerin therapy. treated 62 patients with once week for 6 weeks. Purified tests were performed before after Cold cup bladder biopsies examined blind retrospective manner presence granulomas weeks completion A significant correlation between status free tumor either or positive was observed total patient population. Of 25 whose converted from...
BACKGROUND The cyclin-dependent kinase inhibitor gene p21Waf1/Cip1 plays a role in signaling cellular growth arrest. In response to DNA damage, p21 is induced by the p53 gene, thereby playing direct mediating p53-induced G1 Alterations this may adversely affect regulation of proliferation and increase susceptibility for cancer. Two polymorphisms have previously been characterized gene: C→A transversion at codon 31 (ser→arg) C→T transition 20 nucleotides downstream from 3' end exon 3. METHODS...
No AccessJournal of Urology1 Dec 1992Experimental Autoimmune Cystitis: A Potential Murhne Model for Ulcerative Interstitial Cystitis Arnold D. Bullock, Michael J. Becich, Carl G. Klutke, and Timothy L. Ratliff BullockArnold Bullock , BecichMichael Becich KlutkeCarl Klutke RatliffTimothy View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37091-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail cystitis is an...
Abstract Hepatocytes maintained in collagen gels remain differentiated for prolonged periods of time compared to cells on conventional cultures. Previous studies with other culture systems which chemical supplements or substratum modifications enhanced hepatocyte differentiation showed that all these hepatocytes do not respond mitogens. In this study it is shown between two layers mitogens HGF (also known as scatter factor (HGF/SF)) and epidermal growth (EGF). Cell density did affect the...
The Big Data to Knowledge (BD2K) Center for Causal Discovery is developing and disseminating an integrated set of open source tools that support causal modeling discovery biomedical knowledge from large complex datasets. integrates teams data scientists focused on the refinement existing development new constraint-based Bayesian algorithms based networks, optimization software efficient operation in a supercomputing environment, testing developed using real 3 representative driving projects:...