A5011556876- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Pelvic floor disorders treatments
- Radiomics and Machine Learning in Medical Imaging
- Sexual function and dysfunction studies
- Urinary Tract Infections Management
- Receptor Mechanisms and Signaling
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Advanced Radiotherapy Techniques
- Nitric Oxide and Endothelin Effects
- Epigenetics and DNA Methylation
- Neuropeptides and Animal Physiology
- Tissue Engineering and Regenerative Medicine
- MRI in cancer diagnosis
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Genital Health and Disease
- Health Systems, Economic Evaluations, Quality of Life
New York University
2015-2024
NYU Langone Health
2015-2024
New York Proton Center
2011-2020
CARE Canada
2019
American Museum of Natural History
2018
John Wiley & Sons (United States)
2015-2017
Urology Associates
1995-2016
Albert Einstein College of Medicine
2004-2012
Jilin University
2011
George Washington University
2010
Benign prostatic hyperplasia is commonly treated with alpha-adrenergic-receptor antagonists (alpha-blockers) or 5alpha-reductase inhibitors. The long-term effect of these drugs, singly combined, on the risk clinical progression unknown.We conducted a long-term, double-blind trial (mean follow-up, 4.5 years) involving 3047 men to compare effects placebo, doxazosin, finasteride, and combination therapy measures benign hyperplasia.The overall progression--defined as an increase above base line...
The technique for radical retropubic prostatectomy has been modified to avoid injury the branches of pelvic plexus that innervate corpora cavernosa. surgical procedure is based on an understanding anatomical relationships between cavernosa, capsular prostatic vessels provide scaffolding these nerves, and lateral fascia. modifications involve two steps in procedure: 1) incision fascia placed anterior neurovascular bundle, which located dorsolateral prostate along sidewall; 2) pedicle divided...
Men with benign prostatic hyperplasia can be treated α1-adrenergic–antagonist drugs that relax smooth muscle or inhibit 5α-reductase and therefore reduce tissue androgen concentrations. However, the effects of two types have not been compared.
We assessed the relationship between changes in scores for American Urological Association (AUA) symptom index and benign prostatic hyperplasia (BPH) impact with patient global ratings of improvement a large Veterans Affairs trial comparing different pharmacological therapies BPH.The primary analyses compared absolute score from baseline at 13 weeks 1,218 men.Subjects who rated themselves as being slightly improved had mean decrease AUA BPH 3.1 0.4 points, respectively. However, strongly...
No AccessJournal of Urology1 Feb 1985Precise Localization the Autonomic Nerves From pelvic Plexus to Corpora Cavernosa: a Detailed Anatomical Study Adult Male Pelvisis companion ofNote by Editor Herbert Lepor, Marjorie Gregerman, Ranice Crosby, Fathollah K. Mostofi, and Patrick C. Walsh LeporHerbert Lepor , GregermanMarjorie Gregerman CrosbyRanice Crosby MostofiFathollah Mostofi WalshPatrick View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)48885-9AboutPDF ToolsAdd...
No AccessJournal of UrologyClinical Urology: Original Articles1 Feb 1998TWO CONSECUTIVE SETS OF TRANSRECTAL ULTRASOUND GUIDED SEXTANT BIOPSIES THE PROSTATE FOR DETECTION CANCER Michael A. Levine, Ittman, Jonathan Melamed, and Herbert Lepor LevineMichael Levine , IttmanMichael Ittman MelamedJonathan Melamed LeporHerbert View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63951-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...
Significance E-cigarette smoke (ECS) delivers nicotine through aerosols without burning tobacco. ECS is promoted as noncarcinogenic. We found that induces DNA damage in mouse lung, bladder, and heart reduces DNA-repair functions proteins lung. Nicotine its nitrosation product 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone can cause the same effects enhance mutations tumorigenic cell transformation cultured human lung bladder cells. These results indicate occurs heart, products are further...
Significance Electronic-cigarette smoke (ECS) is designed to deliver nicotine, and its use gaining popularity. Previously, we found that ECS induces DNA damage inhibits repair in the mouse lungs bladder urothelium. Nicotine same types of adducts has a similar effect on inhibition human cells. also enhances cells’ mutation tumorigenic transformation susceptibility. Our current results show ECS-exposed mice developed lung adenocarcinoma urothelial hyperplasia, indicating carcinogen potential...
To evaluate the efficacy and safety of two once-daily doses tamsulosin, first selective alpha1A-antagonist studied in clinical trials.Patients with benign prostatic hyperplasia (BPH) were randomized to receive either tamsulosin (0.4 0.8 mg/day) or placebo (n = 756). Primary parameters improvement total American Urological Association (AUA) symptom score peak urinary flow (Qmax). Secondary measurements at individual double-blind visits corresponding primary parameters; percentage patients a...
Molecular cloning studies have revealed the existence of three subtypes alpha 1-adrenergic receptors. However, link between any individual subtype and its functional role in body has remained elusive. In an effort to bridge gap molecular biology pathophysiology, we chosen a model smooth muscle system, human prostate, investigated 1 this tissue. To determine which receptor mediates contractile response first studied pharmacological properties cloned (alpha 1a/d, 1b, 1c). Prazosin, terazosin,...
No AccessJournal of Urology1 Nov 1992A Randomized, Placebo-Controlled Multicenter Study the Efficacy and Safety Terazosin in Treatment Benign Prostatic Hyperplasia Herbert Lepor, Stephen Auerbach, Anthony Puras-Baez, Perinchery Narayan, Mark Soloway, Franklin Lowe, Timothy Moon, Gary Leifer, Paul Madsen LeporHerbert Lepor , AuerbachStephen Auerbach Puras-BaezAnthony Puras-Baez NarayanPerinchery Narayan SolowayMark Soloway LoweFranklin Lowe MoonTimothy Moon LeiferGary Leifer MadsenPaul View...
We critically examined the intraoperative and postoperative complications associated with radical retropubic prostatectomy in modern era.Between April 18, 1994 July 13, 2000, 1,000 men underwent performed by a single surgeon. The whole inpatient hospital medical record of 909 patients, outpatient charts 955 self-administered patient survey completed 679 were reviewed 2 data managers not involved surgical management or followup care. In all cases at least 1 3 sources was reviewed.Mean age...
Stem cells are believed to regulate normal prostatic homeostasis and play a role in the etiology of prostate cancer benign hyperplasia. We show here that proximal region mouse ducts is enriched subpopulation epithelial exhibit three important attributes stem cells: they slow cycling, possess high vitro proliferative potential, can reconstitute highly branched glandular ductal structures collagen gels. propose model which concentrated while transit-amplifying occupy distal ducts. This account...
No AccessJournal of Urology1 May 1992The Relative Proportion Stromal and Epithelial Hyperplasia is Related to the Development Symptomatic Benign Prostate Ellen Shapiro, Michael J. Becich, Victor Hartanto, Herbert Lepor ShapiroEllen Shapiro , BecichMichael Becich HartantoVictor Hartanto LeporHerbert View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37546-8AboutPDF ToolsAdd favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Mar 2004The Impact Open Radical Retropubic Prostatectomy on Continence and Lower Urinary Tract Symptoms: A Prospective Assessment Using Validated Self-Administered Outcome Instrumentsis corrected byRE: THE IMPACT OF OPEN RADICAL RETROPUBIC PROSTATECTOMY ON CONTINENCE AND LOWER URINARY TRACT SYMPTOMS: PROSPECTIVE ASSESSMENT USING VALIDATED SELF-ADMINISTERED OUTCOME INSTRUMENTSRE: INSTRUMENTS HERBERT LEPOR LEDIA KACI LEPORHERBERT...
No AccessJournal of Urology1 Mar 1990The Efficacy Transurethral Resection the Prostate in Men with Moderate Symptoms Prostatism Herbert Lepor and Gilbert Rigaud LeporHerbert RigaudGilbert View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)40012-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail resection prostate represents operation most commonly performed by urologists United States. The objective this study...
Abstract The objective of the present study was to determine whether smooth muscle content prostate adenoma is related clinical response terazosin, a long‐acting selective alpha, blocker. Multiple random biopsies were obtained from 26 male subjects with symptomatic benign prostatic hyperplasia (BPH) prior initiating therapy terazosin. Double immunoenzymatic staining and computer‐assisted quantitative color image analysis utilized quantify area density muscle, connective tissue, glandular...
No AccessJournal of Urology1 Aug 1984The Inheritance the Exstrophy-Epispadias Complex Ellen Shapiro, Herbert Lepor, and Robert D. Jeffs ShapiroEllen Shapiro , LeporHerbert Lepor JeffsRobert View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)49605-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The inheritance pattern exstrophy-epispadias complex was investigated by a combined literature review survey...