A5005021251- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Pain Management and Treatment
- Air Quality Monitoring and Forecasting
- Occupational Health and Performance
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Energy and Environment Impacts
- Musculoskeletal pain and rehabilitation
- Stochastic processes and statistical mechanics
- Carcinogens and Genotoxicity Assessment
- Inhalation and Respiratory Drug Delivery
- Injury Epidemiology and Prevention
- Spine and Intervertebral Disc Pathology
- Noise Effects and Management
- Theoretical and Computational Physics
- Heavy Metal Exposure and Toxicity
- Nanoparticles: synthesis and applications
- Botulinum Toxin and Related Neurological Disorders
- Mathematical Dynamics and Fractals
- Parkinson's Disease Mechanisms and Treatments
- Biomarkers in Disease Mechanisms
- Markov Chains and Monte Carlo Methods
- Pain Mechanisms and Treatments
- Toxic Organic Pollutants Impact
New York University
2016-2025
Boston Scientific (Netherlands)
2020-2024
International Union Against Tuberculosis and Lung Disease
2024
Neuromod (Ireland)
2023-2024
National Taiwan University
2017-2023
National Chengchi University
2017-2023
Boston Scientific (United States)
2015-2023
National Center for Theoretical Sciences
2018-2023
The Spine Institute
2023
Zhejiang Chinese Medical University
2021
<h3>Background:</h3> Previous cross-sectional data showed that children and adolescents with attention-deficit hyperactivity disorder (ADHD) are at increased risk of comorbid conduct, mood, anxiety disorders as well impairments in cognitive, social, family, school functioning. However, longitudinal were needed to confirm these initial impressions. <h3>Methods:</h3> Using DSM-III-R structured diagnostic interviews raters blinded diagnosis, we reexamined psychiatric diagnoses 1- 4-year...
Background— There is a strong link between urbanization and type 2 diabetes mellitus. Although multitude of mechanisms have been proposed, there are no studies evaluating the impact ambient air pollutants propensity to develop We hypothesized that exposure fine particulate matter (<2.5 μm; PM 2.5 ) exaggerates diet-induced insulin resistance, adipose inflammation, visceral adiposity. Methods Results— Male C57BL/6 mice were fed high-fat chow for 10 weeks randomly assigned concentrated or...
Particulate air pollution has been associated with respiratory and cardiovascular disease. Evidence for neurodegenerative effects of ambient particles was reviewed as part a workshop. The purpose this critical update is to summarize the evidence presented mechanisms involved in translocation from lung other organs highlight potential cause effects. Fine ultrafine particles, after deposition on surfactant film at air-liquid interface, are displaced by surface forces exerted them may then...
The explosion and collapse of the World Trade Center (WTC) was a catastrophic event that produced an aerosol plume impacting many workers, residents, commuters during first few days after 11 September 2001. Three bulk samples total settled dust smoke were collected at weather-protected locations east WTC on 16 17 2001; these are representative generated material immediately fire concurrent two structures. We analyzed each sample, not differentiated by particle size, for inorganic organic...
This study investigated the role of maternal smoking during pregnancy in etiology attention deficit hyperactivity disorder (ADHD).Subjects were 6-17-year-old boys with DSM-III-R ADHD (N = 140) and normal comparison subjects 120) their first-degree biological relatives. Information on was obtained from mothers a standardized manner by raters who blind to proband's clinical status.Twenty-two percent children had history pregnancy, compared 8% subjects. positive association remained significant...
Fine particulate matter (FPM) in ambient air causes premature mortality due to cardiac disease susceptible populations.
Significance E-cigarette smoke (ECS) delivers nicotine through aerosols without burning tobacco. ECS is promoted as noncarcinogenic. We found that induces DNA damage in mouse lung, bladder, and heart reduces DNA-repair functions proteins lung. Nicotine its nitrosation product 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone can cause the same effects enhance mutations tumorigenic cell transformation cultured human lung bladder cells. These results indicate occurs heart, products are further...
Chronic exposure to ambient air-borne particulate matter of < 2.5 μm (PM₂.₅) increases cardiovascular risk. The mechanisms by which inhaled particles are sensed and how these effects systemically transduced remain elusive.To investigate the molecular PM₂.₅ mediates inflammatory responses in a mouse model chronic exposure.Here, we show that promotes Ly6C(high) monocyte egress from bone-marrow their entry into tissue niches where they generate reactive oxygen species via NADPH oxidase....
To evaluate the role of early-life exposure to airborne fine particulate matter (diameter, <2.5 μm [PM(2.5)]) pollution on metabolic parameters, inflammation, and adiposity; investigate involvement oxidative stress pathways in development abnormalities.PM(2.5) inhalation (6 h/d, 5 d/wk) was performed C57BL/6 mice (wild type) deficient cytosolic subunit nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p47(phox) (p47(phox-/-)) beginning at age 3 weeks for a duration 10 weeks. Both...
We have previously shown that chronic exposure to ambient fine particulate matter (less than 2.5 μm in aerodynamic diameter, PM₂.₅) pollution conjunction with high-fat diet induces insulin resistance through alterations inflammatory pathways. In this study, we evaluated the effects of PM₂.₅ over a substantive duration rodent's lifespan and focused on impact long-term adipose structure function. C57BL/6 mice were exposed or filtered air (FA) (6 h/day, 5 days/week) for 10 months Columbus, OH....
This paper presents the first comprehensive investigation of PM2.5 and PM10 composition sources in Saudi Arabia. We conducted a multi-week multiple sites sampling campaign Jeddah between June September, 2011, analyzed samples by XRF. The overall mean mass concentration was 28.4 ± 25.4 μg/m3 for 87.3 47.3 PM10, with significant temporal spatial variability. average ratio PM2.5/PM10 0.33. Chemical data were modeled using factor analysis varimax orthogonal rotation to determine five four...
Significance Electronic-cigarette smoke (ECS) is designed to deliver nicotine, and its use gaining popularity. Previously, we found that ECS induces DNA damage inhibits repair in the mouse lungs bladder urothelium. Nicotine same types of adducts has a similar effect on inhibition human cells. also enhances cells’ mutation tumorigenic transformation susceptibility. Our current results show ECS-exposed mice developed lung adenocarcinoma urothelial hyperplasia, indicating carcinogen potential...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
The catastrophic destruction of the World Trade Center (WTC) on 11 September 2001 caused release high levels airborne pollutants into local environment. To assess toxicity fine particulate matter [particulate with a mass median aerodynamic diameter < 2.5 microm (PM2.5)], which may adversely affect health workers and residents in area, we collected fallen dust samples 12 13 from sites within half-mile Ground Zero. Samples WTC were sieved, aerosolized, size-separated, PM2.5 fraction was...
Fine particulate matter <2.5 microm (PM(2.5)) has been implicated in vasoconstriction and potentiation of hypertension humans. We investigated the effects short-term exposure to PM(2.5) angiotensin II (AII) infusion model.Sprague-Dawley rats were exposed or filtered air (FA) for 10 weeks. At week 9, minipumps containing AII implanted responses studied over a week. Mean concentration inside chamber was 79.1+/-7.4 microg/m(3). After infusion, mean arterial pressure significantly higher...
Changes in methylation of CpG sites at the interleukin (IL)-4 and interferon (IFN)-γ promoters are associated with T helper (Th) 2 polarization vitro. No previous studies have examined whether air pollution or allergen exposure alters these two genes vivo. We hypothesized that diesel exhaust particles (DEP) would induce hypermethylation IFN-γ promoter hypomethylation IL-4 CD4+ cells among mice sensitized to fungus Aspergillus fumigatus. also DEP-induced changes affect immunoglobulin (Ig) E...
Recent studies have suggested a link between inhaled particulate matter (PM) exposure and increased mortality morbidity associated with pulmonary cardiovascular diseases. However, precise understanding of the biological mechanism underlying PM-associated toxicity pathogenesis remains elusive. Here, we investigated impact PM in intracellular stress signaling pathways animal models cultured cells. Inhalation mice to environmentally relevant fine (aerodynamic diameter < 2.5 μm, ) induces...
Abstract Background Prior studies have demonstrated a link between air pollution and metabolic diseases such as type II diabetes. Changes in adipose tissue its mitochondrial content/function are closely associated with the development of insulin resistance attendant complications. We investigated changes structure function brown white depots response to chronic ambient pollutant exposure rodent model. Methods Male ApoE knockout (ApoE -/- ) mice inhaled concentrated fine PM (PM < 2.5 μm...