A5017730279- Heavy Metal Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Analytical chemistry methods development
- Carcinogens and Genotoxicity Assessment
- Pesticide Exposure and Toxicity
- Trace Elements in Health
- Drug Transport and Resistance Mechanisms
- Heavy metals in environment
- Air Quality and Health Impacts
- Mercury impact and mitigation studies
- Chemotherapy-induced organ toxicity mitigation
- Electron Spin Resonance Studies
- Environmental Toxicology and Ecotoxicology
- Paraquat toxicity studies and treatments
- Mycotoxins in Agriculture and Food
- Customer churn and segmentation
- Birth, Development, and Health
- Chromium effects and bioremediation
- Pharmacological Effects and Toxicity Studies
- Arsenic contamination and mitigation
- Mass Spectrometry Techniques and Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Water Treatment and Disinfection
- X-ray Diffraction in Crystallography
Environmental and Occupational Health Sciences Institute
2015-2024
Rutgers, The State University of New Jersey
2015-2024
University of Tampa
2023
Rutgers Sexual and Reproductive Health and Rights
1996-2022
University College Dublin
2010-2022
Wellcome Trust
2019
Ottawa Hospital
2019
Ottawa Hospital Research Institute
2019
Philippine General Hospital
2019
University of the Philippines Manila
2019
The explosion and collapse of the World Trade Center (WTC) was a catastrophic event that produced an aerosol plume impacting many workers, residents, commuters during first few days after 11 September 2001. Three bulk samples total settled dust smoke were collected at weather-protected locations east WTC on 16 17 2001; these are representative generated material immediately fire concurrent two structures. We analyzed each sample, not differentiated by particle size, for inorganic organic...
<h3>Importance</h3> The causes of late-onset Alzheimer disease (AD) are not yet understood but likely include a combination genetic, environmental, and lifestyle factors. Limited epidemiological studies suggest that occupational pesticide exposures associated with AD. Previously, we reported serum levels dichlorodiphenyldichloroethylene (DDE), the metabolite dichlorodiphenyltrichloroethane (DDT), were elevated in small number patients AD (n=20). <h3>Objective</h3> To evaluate association...
Quantitative examination of major pathways and routes exposure to pesticides is essential for determining human risk. The current study was conducted in two apartments examines the accumulation pesticide chlorpyrifos childrens' toys after time suggested reentry application. It has been established first that a semivolatile will accumulate on other sorbant surfaces home via two-phase physical process continues at least 2 weeks postapplication. A summation above 3-6-year-old child yielded an...
Sulforaphane (SUL) is one member of the isothiocyanate class cancer chemopreventive compounds that has been shown to be effective in blocking initiation and progression carcinogenesis. Previously, many studies have SUL can potently induce phase II detoxifying enzymes, which contributes its functions. In this study, we used 4967 oligonucleotides microarray assess genes are modulated by vivo rat livers, as well time course expression these genes. The pharmacokinetics was assessed after oral...
Bile acids (BAs) are amphipathic molecules important for metabolism of cholesterol, absorption lipids and lipid soluble vitamins, bile flow, regulation gut microbiome. There over 30 different BA species known to exist in humans mice, which endogenous modulators at least 6 membrane or nuclear receptors. This diversity ligands receptors play roles health disease; however, the full functions each individual vivo remain unclear. We generated a mouse model lacking initiating enzymes, CYP7A1...
Recent studies in experimental animals found that oral exposure to micro- and nano-plastics (MNPs) during pregnancy had multiple adverse effects on outcomes progeny, although no study has yet identified the translocation of ingested MNPs placenta or fetal tissues, which might account for those effects. We therefore assessed placental nanoscale polystyrene pregnant rats. Sprague Dawley rats (N = 5) were gavaged gestational day 19 with 10 mL/kg 250 µg/mL 25 nm carboxylated spheres (PS25C)...
The bioaccessible fraction of metals in the stomach has been estimated for two soil materials using laboratory synthesized gastric juice. Heavy present each matrix were extracted and measured, as a technique to simulate metal solubilization processes that occur human stomach. results from synthetic juice extraction compared values obtained modified EPA concentrated acid procedure, method 3051, on same soils. experiments evaluated effect varying liquid solid ratio efficiency arsenic (As),...
Oxidative stress has been implicated in the pathogenesis of Parkinson disease based on its role cascade biochemical changes that lead to dopaminergic neuronal death. This study analyzed oxidative as a mechanism neurotoxicity produced by combined paraquat and maneb model phenotype. Transgenic mice overexpressing either Cu,Zn superoxide dismutase or intracellular glutathione peroxidase non-transgenic were exposed saline, paraquat, combination + twice week for 9 weeks. Non-transgenic...
<h3>Background</h3> Exposure to pesticides has been reported increase the risk of Parkinson disease (PD), but identification specific is lacking. Three studies have found elevated levels organochlorine in postmortem PD brains. <h3>Objective</h3> To determine whether are present serum patients with PD. <h3>Design</h3> Case-control study. <h3>Setting</h3> An academic medical center. <h3>Participants:</h3> Fifty PD, 43 controls, and 20 Alzheimer disease. <h3>Main Outcome Measures</h3> Levels 16...
Early life exposure to Bisphenol A (BPA), a component of polycarbonate plastics and epoxy resins, alters sociosexual behavior in numerous species including humans. The present study focused on the ontogeny these behavioral effects beginning adolescence assessed underlying molecular changes amygdala. We also explored mitigating potential soy-rich diet endpoints. Wistar rats were exposed BPA via drinking water (1 mg/L) from gestation through puberty, reared soy-based or soy-free diet. group...
Phthalates and bisphenol A (BPA) are ubiquitous environmental toxicants, present in high concentrations numerous consumer products. We hypothesized that maternal exposure to phthalates BPA pregnancy is associated with shortened gestation.Urinary phthalate metabolites from 72 pregnant women were measured at the last obstetric clinic visit prior delivery. Using linear regression models, we estimated change gestational age each interquartile range (IQR) increase metabolite concentration.IQR...
Bile acids (BAs) are diverse molecules that synthesized from cholesterol in the liver. The synthesis of BAs has traditionally been shown to occur through two pathways. Cholesterol 7α‐hydroxylase (CYP7A1) performs initial and rate‐limiting step classical pathway, sterol 27‐hydroxylase (CYP27A1) initiates hydroxylation alternative pathway. While role individual BA species as physiological detergents is relatively ubiquitous, their endocrine functions signaling roles disease pathogenesis have...
Tea has been proposed to have beneficial health effects which attributed the polyphenolic compounds known as catechins. The bioavailability and biotransformation of these compounds, however, are not clearly understood. In this study, we used liquid chromatography/electrospray ionization-mass spectrometry (LC/ESI-MS) determine urinary glucuronidated sulfated tea catechins their metabolites (including methylated ring-fission metabolites) based on detection deprotonated molecular ions aglycone...
BackgroundParaquat (PQ) has been implicated as a risk factor for the Parkinson disease phenotype (PDP) in humans and mice using epidemiologic or experimental approaches. The toxicokinetics (TK) toxicodynamics (TD) of PQ brain are not well understood.ObjectivesThe TK TD were measured after single repeated doses.MethodsBrain regions analyzed levels, amount lipid peroxidation, functional activity 20S proteasome.ResultsParaquat (10 mg/kg, ip) was found to be persistent mouse ventral midbrain...
Tea is rich in polyphenols and has a variety of biological activities. In order to better understand the effects tea constituents on human health, markers for their exposure metabolic fates are needed. Previously, we have characterized several catechin metabolites blood urine, but more information metabolite profile present study, urinary was investigated using liquid chromatography/electrospray ionization tandem mass spectrometry with data-dependent acquisition. With MS/MS analysis by...