A5060411997- Gut microbiota and health
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Dye analysis and toxicity
- Carbon and Quantum Dots Applications
- Advanced Cellulose Research Studies
- Microbial Metabolites in Food Biotechnology
- Proteins in Food Systems
- Metabolomics and Mass Spectrometry Studies
- Autophagy in Disease and Therapy
- Recycling and Waste Management Techniques
- Effects and risks of endocrine disrupting chemicals
- Advanced Nanomaterials in Catalysis
- Fungal Biology and Applications
- Tea Polyphenols and Effects
- Microplastics and Plastic Pollution
- Nanocomposite Films for Food Packaging
- Food composition and properties
- Probiotics and Fermented Foods
- Public Health and Nutrition
- Saffron Plant Research Studies
- Bioactive Compounds in Plants
- Studies on Chitinases and Chitosanases
- Phytochemicals and Antioxidant Activities
- Sirtuins and Resveratrol in Medicine
Harvard University
2019-2023
University of Massachusetts Amherst
2016-2023
Amherst College
2017-2021
Harvard University Press
2020
Tongren Hospital
2019
Shanghai Jiao Tong University
2019
Cellulose is widely used as a thickener and filler in foods drugs. It has been designated "generally regarded safe" (GRAS). Nanocellulose (NC) many additional potential applications designed to improve food quality safety, but not yet GRAS. Here we present results of toxicological studies ingested NC physiologically relevant vitro vivo systems. In employed gastrointestinal tract simulator digest two widely-used forms NC, nanocellulose fibrils (CNF) cellulose nanocrystals (CNC), at 0.75 1.5%...
Strawberry (Fragaria chiloensis) is a major edible berry with various potential health benefits. This study determined the protective effects of whole strawberry (WS) against dextran-sulfate-sodium-induced colitis in mice. In colitic mice, dietary WS reduced disease activity index, prevented colon shortening and spleen enlargement, alleviated colonic tissue damages. The abundance proinflammatory immune cells was by mucosa, which accompanied suppression overproduction cytokines. Western...
Abstract The recent ban of titanium dioxide (TiO 2 ) as a food additive (E171) in France intensified the controversy on safety foodborne‐TiO nanoparticles (NPs). This study determines biological effects TiO NPs and obese non‐obese mice. Oral consumption (0.1 wt% diet for 8 weeks) (E171, 112 nm) (33 does not cause severe toxicity mice, but significantly alters composition gut microbiota, example, increased abundance Firmicutes phylum decreased Bacteroidetes Bifidobacterium Lactobacillus...
Although resveratrol (RES) is barely detectable in the plasma and tissues upon oral consumption, collective evidence reveals that RES presents various bioactivities vivo, including anti-inflammation anti-cancer. This paradox necessitates further research on profiling characterizing biotransformation of RES, as its metabolites may contribute profound biological effects. After 4-week administration, 11 were identified quantified mice by HPLC-MS/MS, dihydro-resveratrol (DHR), lunularin (LUN),...
Despite mounting evidence of micro-nanoplastics (MNPs) in food and drinking water, little is known the potential health risks ingested MNPs, nothing their impact on nutrient digestion absorption. We assessed effects environmentally relevant secondary MNPs generated by incineration polyethylene (PE-I), absorption fat a high model using 3-phase
The ability of casein phosphopeptides (CPPs) to bind and transport minerals has been previously studied. However, the single bioactive peptides responsible for effects CPPs have not identified. This study was purify calcium-binding from determine their on calcium magnesium uptake by Caco-2 cell monolayers. Five monomer designated P1 P5 were isolated amino acid sequences determined using LC-MS/MS. Compared with CPP-free control, all five monomeric exhibited significant enhancing (P < 0.05)....
Nanosized titanium dioxide (TiO2) particles are commonly present in TiO2 food additives (E171) and have been associated with potential adverse effects on health. However, little knowledge is available regarding the interactions between nanoparticles (NPs) other components, such as flavonoids. In this study, we aim to study molecular anatase NPs three structurally closely related polymethoxyflavones (PMFs, flavonoids found citrus fruits), namely, 3',4'-didemethylnobiletin (DDN),...
Triclocarban (TCC) is a widely used antimicrobial ingredient in consumer products and ubiquitous contaminant the environment. In 2016, FDA removed TCC from over-the-counter handwashing products, but this compound still approved for use many other personal care products. A better understanding of its impact on human health could lead to significant public regulatory policies. Here we show that exposure low-dose exaggerated severity colitis exacerbated development colitis-associated colon...
Many toxicity investigations have evaluated the potential health risks of ingested engineered nanomaterials (iENMs); however, few addressed combined effects iENMs and other toxic compounds (e.g. pesticides) in food. To address this knowledge gap, we investigated two widely used, partly nanoscale, particulate food additives, TiO2 (E171) SiO2 (E551), on cytotoxicity cellular uptake translocation pesticide boscalid. Fasting model (phosphate buffer) containing iENM (1% w/w), boscalid (10 or 150...
Abstract In the last decade, along with increasing use of graphene oxide (GO) in various applications, there is also considerable interest understanding its effects on human health. Only a few experimental approaches can simulate common routes exposure, such as ingestion, due to inherent complexity digestive tract. This study presents synthesis size‐sorted GO sub‐micrometer‐ or micrometer‐sized lateral dimensions, physicochemical transformations across mouth, gastric, and small intestinal...
The present study demonstrated the anti-inflammatory and gut microbiota regulatory effects of a <italic>Pleurotus eryngii</italic> polysaccharide as functional natural component beneficial prebiotic candidate against IBD.
A green, facile, and rapid method for microextraction Raman detection of titanium dioxide nanoparticles from milk powder is reported.
Nanoscale chitosan materials exhibit size-specific properties that make them useful in agri-food and biomedical applications. Chitosan nanoparticles (Chnps) are being explored as nanocarrier platforms to increase oral bioavailability of drugs nutraceuticals, but little is known their fate transformations the gastrointestinal tract (GIT) or potential toxicity. Here, GIT cytotoxicity Chnps, soluble starch-coated Chnps (SS-Chnps), bulk powder (Chp), were assessed using a 3-phase simulated...
Background : engineered nanomaterials (ENMs) have already made their way into myriad applications and products across multiple industries.
Astrocytes protection and functional regulation are important strategies to protect against neuronal damage caused by ischemia. Activation of the delta opioid receptor (DOR) could reduce astrocytes damage, although mechanism remains unclear. The present study aimed test effect DOR activation on autophagy in exposed oxygen-glucose deprivation (OGD), further investigate whether this has a protective astrocytes. Primary cultured rat cortical were treated with various doses [d-Ala2,...