A5016212755- Air Quality and Health Impacts
- Asthma and respiratory diseases
- Climate Change and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Air Quality Monitoring and Forecasting
- Inhalation and Respiratory Drug Delivery
- Olfactory and Sensory Function Studies
- Neonatal Respiratory Health Research
- Advanced Chemical Sensor Technologies
- Carcinogens and Genotoxicity Assessment
- Immune Response and Inflammation
- Allergic Rhinitis and Sensitization
- Noise Effects and Management
- Medical and Biological Ozone Research
- Toxic Organic Pollutants Impact
- Fatty Acid Research and Health
- Biochemical Analysis and Sensing Techniques
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Systemic Lupus Erythematosus Research
- Heme Oxygenase-1 and Carbon Monoxide
- Effects and risks of endocrine disrupting chemicals
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cystic Fibrosis Research Advances
- Odor and Emission Control Technologies
Michigan State University
2015-2024
Utah State University
2024
Eastern Michigan University
2021
Michigan United
2006-2020
New York University
1995-2020
New York State Department of Environmental Conservation
2020
Harvard University
2009-2020
Colorado School of Public Health
2020
North Carolina State University
2020
American Thoracic Society
2020
Air pollution is associated with significant adverse health effects, including increased cardiovascular morbidity and mortality. Exposure to particulate matter an aerodynamic diameter of <2.5 microm (PM(2.5)) increases ischemic events promotes atherosclerosis. Moreover, there increasing evidence that the smallest pollutant particles pose greatest danger because their high content organic chemicals prooxidative potential. To test this hypothesis, we compared proatherogenic effects ambient...
Fine particulate matter air pollution plus ozone impairs vascular function and raises diastolic blood pressure. We aimed to determine the mechanism pollutant responsible. The effects of on heart rate variability, pressure, biomarkers, brachial flow-mediated dilatation were determined in 2 randomized, double-blind, crossover studies. In Ann Arbor, 50 subjects exposed fine particles (150 μg/m 3 ) (120 parts per billion) for hours occasions with pretreatments an endothelin antagonist (Bosentan,...
The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats Mice) is a joint initiative the Societies Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) North America (STP) to develop an internationally-accepted nomenclature proliferative non-proliferative lesions laboratory animals. purpose this publication provide standardized classifying microscopic observed respiratory tract rats mice, with color photomicrographs...
Although it is well accepted that air pollution exposure exacerbates preexisting airway disease, has not been firmly established long-term increases the risk of new-onset asthma or chronic obstruction pulmonary disease (COPD). This Workshop brought together experts on mechanistic, epidemiological, and clinical aspects to review current knowledge regarding whether a causal factor in development and/or COPD. Speakers presented recent evidence their respective areas expertise related new...
Background In 2003, severe acute respiratory syndrome coronavirus (SARS-CoV) was identified as the etiological agent of syndrome, a disease characterized by pneumonia that sometimes results in death. SARS-CoV is zoonotic virus crossed species barrier, most likely originating from bats or other including civets, raccoon dogs, domestic cats, swine, and rodents. A vaccine should confer long-term protection, especially vulnerable senescent populations, against both 2003 epidemic strains may yet...
It has been demonstrated that ambient particulate matter (PM) can act as an adjuvant for allergic sensitization. Redox-active organic chemicals on the particle surface play important role in PM adverse health effects and may determine effect of different types according to their potential perturb redox equilibrium immune system.We determined whether fine particles versus ultrafine (UFPs) is correlated prooxidant potential.We have established intranasal sensitization model uses a ovalbumin...
Abstract Background Prior studies have demonstrated a link between air pollution and metabolic diseases such as type II diabetes. Changes in adipose tissue its mitochondrial content/function are closely associated with the development of insulin resistance attendant complications. We investigated changes structure function brown white depots response to chronic ambient pollutant exposure rodent model. Methods Male ApoE knockout (ApoE -/- ) mice inhaled concentrated fine PM (PM < 2.5 μm...
Background: Epidemiologic and experimental studies support an association between PM2.5 exposure insulin resistance (IR). Innate immune cell activation has been suggested to play a role in the pathogenesis of these effects.Objectives: We sought evaluate CC-chemokine receptor 2 (CCR2) PM2.5-mediated inflammation IR.Methods: Wild-type C57BL/6 CCR2–/– male mice were fed high-fat diet exposed either concentrated ambient or filtered air for 17 weeks via whole-body system. evaluated glucose...
Exposure to particulate matter≤2.5 μm in diameter (PM2.5) increases blood pressure (BP) humans and animal models. Abnormal activation of the sympathetic nervous system may have a role acute BP response PM2.5 exposure. The mechanisms responsible for its chronic sustenance hypertension exposure are currently unknown.We investigated whether central inflammation be implicated exposure-induced activation.C57BL/6J mice were exposed concentrated ambient (CAPs) 6 months, we analyzed using...
In an effort to further characterize conserved and species-specific mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated toxicity, comparative temporal dose-response microarray analyses were performed on hepatic tissue from immature, ovariectomized Sprague Dawley rats C57BL/6 mice. For studies, mice gavaged with 10 or 30 microg/kg TCDD, respectively, sacrificed after 2, 4, 8, 12, 18, 24, 72, 168 h while studies at 24 h. Hepatic gene expression profiles monitored using custom...
In an effort to further characterize the mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated toxicity, comprehensive temporal and dose–response microarray analyses were performed on hepatic tissue from immature ovariectomized C57BL/6 mice treated with TCDD. For analysis, gavaged 30 μg/kg TCDD or vehicle sacrificed after 2, 4, 8, 12, 18, 24, 72, 168 h. Dose–response 0, 0.001, 0.01, 0.1, 1, 10, 100, 300 24 Hepatic gene expression profiles monitored using custom cDNA microarrays...
Rationale: Chronic obstructive pulmonary disease is a leading cause of death worldwide, but its pathogenesis not well understood. Previous studies have shown that airway surface dehydration in β-epithelial Na+ channel (βENaC)–overexpressing mice caused chronic lung with high neonatal mortality and bronchitis adult survivors.Objectives: The aim this study was to identify the initiating lesions investigate natural progression by dehydration.Methods: Lung morphology, gene expression,...
Air pollution exposure has been shown to potentiate plaque progression in humans and animals. Our previous studies have suggested a role for oxidized lipids mediating adverse vascular effect of air pollution. However, the types formed response pollutants how this occurs their relevance atherosclerosis are not fully understood.To investigate mechanisms by which particulate matter <2.5 μm (PM2.5) induces atherosclerosis.Atherosclerosis-prone ApoE(-/-) or LDLR(-/-) mice were exposed filtered...
Background: Engineered nanomaterials (ENMs) have potential benefits, but they also present safety concerns for human health. Interlaboratory studies in rodents using standardized protocols are needed to assess ENM toxicity.Methods: Four laboratories evaluated lung responses C57BL/6 mice ENMs delivered by oropharyngeal aspiration (OPA), and three labs Sprague-Dawley (SD) or Fisher 344 (F344) rats following intratracheal instillation (IT). tested included forms of titanium dioxide (TiO2)...
Abstract Background With the increase in production and use of engineered nanoparticles (NP; ≤ 100 nm), safety concerns have risen about potential health effects occupational or environmental NP exposure. Results animal toxicology studies suggest that inhalation may cause pulmonary injury with subsequent acute chronic inflammation. People respiratory diseases like asthma allergic rhinitis be even more susceptible to toxic inhaled NP. Few studies, however, investigated adverse enhance...
Prior experimental and epidemiologic data support a link between exposure to fine ambient particulate matter (<2.5 μm in aerodynamic diameter, PM2.5) development of insulin resistance/Type II diabetes mellitus. This study was designed investigate whether inhalational concentrated PM2.5 genetically susceptible animal model would result abnormalities energy metabolism exacerbation peripheral glycemic control. KKay mice, which are Type DM, were assigned either or filtered air (FA) for 5–8 weeks...