Exposure to particulate matter≤2.5 μm in diameter (PM2.5) increases blood pressure (BP) humans and animal models. Abnormal activation of the sympathetic nervous system may have a role acute BP response PM2.5 exposure. The mechanisms responsible for its chronic sustenance hypertension exposure are currently unknown.We investigated whether central inflammation be implicated exposure-induced activation.C57BL/6J mice were exposed concentrated ambient (CAPs) 6 months, we analyzed using...

Exposure to ambient fine particulate matter (PM2.5) correlates with abnormal glucose homeostasis, but the underlying biological mechanism has not been fully understood. The gut microbiota is an emerging crucial player in homeostatic regulation of metabolism. Few studies have investigated its role PM2.5 exposure-induced abnormalities homeostasis. C57Bl/6J mice were exposed filtered air (FA) or concentrated (CAP) for 12 months using a versatile aerosol concentration enrichment system (VACES)...

Epidemiological studies link ambient fine particulate matter (PM2.5) pollution to abnormalities in the male reproductive system. However, few toxicological have investigated this potentially important adverse effect of PM2.5 pollution. Therefore, present study, we analyzed effects exposure on spermatogenesis and hypothalamic-pituitary-gonadal (HPG) axis a murine model. Fourteen C57BL/6J mice were subjected 4-month filtered air or concentrated (CAP). Their sperm count, testicular histology,...

Background: This study aimed to analyze the research progress on use of a multifocal lens for myopic control throughout 21st century, utilizing bibliometric analysis. Methods: Publications related lenses from 2001 2024 were searched Web Science core collection (WoSCC) database. VOSviewer (Version 1.6.19) and Bibliometrix package 4.3.0) used perform Primary information including publication number per year, country or region, journal, keyword, title literature was extracted analyzed. Results:...

Background: Exposure to ambient fine particulate matter (PM2.5) is associated with cardiovascular mortality, but underlying pathophysiologic mechanisms are not fully understood. Hypothalamic inflammation, characterized by the activation of Inhibitor kappaB kinase 2/Nuclear factor (IKK2/NF-κB) signaling pathway, may play an important role in pathogenesis diseases. We recently demonstrated that hypothalamic inflammation increased mice exposed concentrated PM2.5 (CAP). Objectives: In present...

Many diseases including obesity may originate through alterations in the early-life environment that interrupts fetal development. Increasing evidence has shown exposure to ambient fine particles (PM2.5) is associated with abnormal However, its long-term metabolic effects on offspring have not been systematically investigated. To determine if maternal PM2.5 programs obesity, female C57Bl/6j mice were exposed filtered air (FA) or concentrated (CAP) during pre-conception, pregnancy, and...

Exposure to ambient PM2.5 increases cardiovascular mortality and morbidity. To delineate the underlying biological mechanism, we investigated time dependence of response chronic exposure concentrated (CAP).Spontaneously hypertensive rats (SHR) were exposed CAP for 15 weeks, blood pressure (BP), cardiac function structure, inflammations lung, hypothalamus, heart measured at different points.Chronic significantly increased BP, withdrawal from restored BP. Consistent with its BP effect,...

Both epidemiological and empirical studies have indicated that nickel (Ni) may play an important role in PM2.5 exposure–induced adverse cardiovascular effects. However, the underlying mechanism remains unclear. In present study, we exposed mice to concentrated ambient (CAP), Ni, or coexposure both CAP + Ni a specially designed whole-body exposure system for duration of 3 months investigated their effects on vascular function, oxidative stress, inflammation. induced greater endothelial...

Obesity is one of the leading threats to global public health. It consequent abnormal energy metabolism. Currently, it has been well established that maternal exposure environmental stressors cause inappropriate fetal development may have long-term adverse effects on offspring metabolism in an timing-dependent manner, known as developmental programming health and diseases paradigm. Rapidly increasing evidence indicated ambient fine particles (PM2.5) correlates development. In present study,...

Exposure to ambient PM 2.5 is associated with human premature mortality. However, it has not yet been toxicologically replicated, likely due the lack of suitable animal models. Drosophila frequently used in longevity research many incomparable merits. The present study aims validate models for toxicity through characterizing their biological responses exposure concentrated (CAP). survivorship curve demonstrated that CAP markedly reduced lifespan Drosophila. This antilongevity effect was...

Radiation therapy plays a major role in the treatment of lung cancer patients. However, cells develop resistance to radiation. Tumor radioresistance is complex multifactorial mechanism which may be dependent on DNA damage and repair, hypoxic conditions inside tumor microenvironment, clonal selection radioresistant from heterogeneous site, it cause failure non–small cell (NSCLC). In present investigation caveolin-1 ( CAV-1 ) has been observed highly expressed radiation resistant A549 cells....

Environmental stressors that encounter in early-life and cause abnormal fetal and/or neonatal development may increase susceptibility to non-communicable diseases such as diabetes. Maternal exposure ambient fine particulate matter (PM2.5) is associated with various abnormalities, suggesting it program offspring's In the present study, we therefore examined whether maternal diesel exhaust PM2.5 (DEP), one of major sources urban areas, programs adult glucose metabolism. Female C57Bl/6J mice...

Ambient fine particulate matter (PM

Purpose To investigate whether the Sonic hedgehog (Shh) signaling induces myopic development by increasing expression of matrix metalloproteinase (MMP)-2 in guinea pigs. Methods A translucent diffuser was glued onto right eye to induce form-deprivation myopia (FDM) 10 Four pigs were served as a control group. The other 100 subdivided into 5 groups (20 per group) and received µl intravitreal injection every 2 days for 4 times. Two injected with 20 or 50 µg/ml Shh amino-terminal peptide...

Ambient fine particulate matter (PM2.5) exposure correlates with adverse cardiometabolic effects. The underlying mechanisms have not yet been fully understood. Hypothalamic-pituitary-adrenal (HPA) axis, as the central stress response system, regulates homeostasis and is implicated in progression of various health effects caused by inhalational airborne pollutant exposure. In this study, we investigated whether ambient PM2.5 activates HPA axis its effect mediating PM2.5-induced pulmonary...

Background: Epidemiological studies have shown that exposure to ambient fine particulate matter with aerodynamic diameter less than or equal 2.5 μm (PM2.5) correlates a decrease in sperm count, but the biological mechanism remains elusive. Objectives: This study tested whether hypothalamic inflammation, an emerging pathophysiological mediator, mediates development of lower epididymal count due PM2.5 exposure. Methods: Inhibitor κB kinase 2 (IKK2) was conditionally knocked out either all...

Objective Oxidative stress is implicated in the pathogenesis of atherosclerosis, and Nrf2 transcriptional factor central cellular antioxidant responses. In present study, we investigate effect a dihydrolipoic acid derivative lipoicmethylenedioxyphenol (LMDP) on progression atherosclerosis test whether its mediated by Nrf2. Methods Results Both magnetic resonance imaging (MRI) scanning en face analysis reveal that 14 weeks treatment with LMDP markedly reduced atherosclerotic burden rabbit...

Considerable studies show that maternal exposure to ambient fine particulate matter (PM2.5) programs offspring's susceptibility obesity. However, few have investigated the effect of paternal PM2.5 on energy homeostasis. This study thus tested whether Male C57Bl/6J mice were exposed filtered air or concentrated (CAP) for 12 weeks and then mated with normal female mice. The offspring assessed growth trajectories, food intakes, body compositions, sperm miRNAs those sires profiled by microarray....

Myosin light chain (MLC) phosphorylation determines vascular contractile status. In addition to the classic Ca²⁺-dependent MLC kinase (MLCK), another unidentified kinase(s) also contributes in living cells. Inhibitor κB 2 (IKK2)-deficient mouse embryonic fibroblasts demonstrate abnormal morphology and migration, suggesting that IKK2 may be involved phosphorylation.Therefore, we tested whether is an MLCK cells role of mediating vasoconstriction blood pressure regulation.In present study,...

To evaluate the changes in retinal vessel density and thickness after small incision lenticule extraction (SMILE) with optical coherence tomography angiography (OCTA) myopic patients. In this prospective study, SMILE surgeries were done 46 eyes of 24 patients spherical equivalent (SE) more than -6.0 diopters (D). Retinal at macula optic nerve recorded OCTA before 1 day, 2 weeks, month surgery. Intraocular pressure (IOP), uncorrected distance visual acuity (UDVA), refraction taken same time....