A5100691139- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- Cancer, Stress, Anesthesia, and Immune Response
- MicroRNA in disease regulation
- Neuropeptides and Animal Physiology
- Circular RNAs in diseases
- Redox biology and oxidative stress
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- Air Quality and Health Impacts
- Mesenchymal stem cell research
- RNA regulation and disease
- Biomedical Text Mining and Ontologies
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Climate Change and Health Impacts
- Ferroptosis and cancer prognosis
- Connective tissue disorders research
- Electronic Health Records Systems
- Folate and B Vitamins Research
- Heme Oxygenase-1 and Carbon Monoxide
- Acute Myeloid Leukemia Research
- Phagocytosis and Immune Regulation
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Institute of Hematology & Blood Diseases Hospital
2025
Tsinghua University
2023
State Key Laboratory on Integrated Optoelectronics
2023
Jilin University
2023
Second Hospital of Anhui Medical University
2022-2023
Anhui Medical University
2022-2023
Jiangxi Normal University
2023
Army Medical University
2014-2022
Daping Hospital
2014-2022
Hepatic steatosis is common in patients having severe hyperhomocysteinemia due to deficiency for cystathionine β-synthase. However, the mechanism by which homocysteine promotes development and progression of hepatic unknown. We report here that homocysteine-induced endoplasmic reticulum (ER) stress activates both unfolded protein response sterol regulatory element–binding proteins (SREBPs) cultured human hepatocytes as well vascular endothelial aortic smooth muscle cells. Activation SREBPs...
Background— Apoptotic cell death contributes to atherosclerotic lesion instability, rupture, and thrombogenicity. Recent findings suggest that free cholesterol (FC) accumulation in macrophages induces endoplasmic reticulum (ER) stress/unfolded protein response (UPR) apoptotic death; however, it is not known at what stage of development the UPR induced or whether a correlation exists between activation, FC accumulation, death. Methods Results— Aortic root sections from apolipoprotein...
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease and accelerates atherosclerosis in apoE-/- mice. Despite the observations that homocysteine causes endoplasmic reticulum (ER) stress programmed cell death (PCD) cultured human vascular endothelial cells, cellular factors responsible this effect their relevance to atherogenesis have not been completely elucidated. We report here induces expression of T-cell death-associated gene 51 (TDAG51), a member pleckstrin...
Peroxynitrite, a potent oxidant generated by the reaction of NO with superoxide, has been implicated in promotion atherosclerosis. We designed this study to determine whether peroxynitrite induces its proatherogenic effects through induction endoplasmic reticulum (ER) stress.Human vascular endothelial cells treated Sin-1, generator, induced expression ER chaperones GRP78 and GRP94 increased eIF2alpha phosphorylation. These were inhibited scavenger uric acid. Sin-1 caused depletion ER-Ca2+,...
Exposure to ambient fine particulate matter (PM2.5) correlates with abnormal glucose homeostasis, but the underlying biological mechanism has not been fully understood. The gut microbiota is an emerging crucial player in homeostatic regulation of metabolism. Few studies have investigated its role PM2.5 exposure-induced abnormalities homeostasis. C57Bl/6J mice were exposed filtered air (FA) or concentrated (CAP) for 12 months using a versatile aerosol concentration enrichment system (VACES)...
Abstract Background Particulate matter (PM) is strongly linked to human health and has detrimental effects on the eye. Studies have, however, focused ocular surface, with limited research impact of PM 2.5 intraocular pressure (IOP). Methods To investigate IOP associated mechanism, C57BL/6 mouse eyes were topically exposed a suspension for 3 months, trabecular meshwork (HTM) cells subjected various concentrations in vitro. Cell viability, NLRP3/caspase-1, IL-1β, GSDMD expression, reactive...
Isolated 20q deletion [del(20q)] is a recurrent favorable abnormality in myelodysplastic syndrome (MDS) and may cause of the ASXL1 gene. Meanwhile, mutations are also common individuals with MDS. This study aimed to describe biological clinical implications newly diagnosed MDS patients isolated del(20q). Gene mutation copy number alterations 178 del(20q) were analyzed using DNA next generation sequencing. Twenty-five (14%) found have mutations, which exhibited lower absolute neutrophil...
Abstract Tigecycline is a broad-spectrum, first-in-class glycylcycline antibiotic currently used to treat complicated skin infections and community-acquired pneumonia. However, there accumulating evidence showing that tigecycline has anticancer properties. In this study, we found could inhibit cell proliferation by inducing cell-cycle arrest, but not apoptosis in glioma. To find the underlying mechanism of how inhibits proliferation, expression miRNAs, which were related regulating...
The poor prognosis and minimally successful treatments of malignant glioma indicate a challenge to identify new therapeutic targets which impact progression. Neurotensin (NTS) its high affinity receptor (NTSR1) overexpression induces neoplastic growth predicts the in various malignancies. Whether NTS can promote progression prognostic significance for patients remains unclear. precursor (ProNTS), NTSR1 expression levels were detected by immunobloting Elisa immunohistochemistry assay....
Endoplasmic reticulum (ER) stress causes macrophage cell death within advanced atherosclerotic lesions, thereby contributing to necrotic core formation and increasing the risk of atherothrombotic disease. However' unlike in lesions' appearance dead/apoptotic macrophages early lesions is less prominent. Given that activation unfolded protein response (UPR) detected lesion-resident can enhance survival against ER stress' we investigated whether UPR occurs after monocyte differentiation confers...
This work constitutes the first known report on lncRNA expression patterns of ectopic and eutopic endometrial tissues in human adenomyosis.
Neurotensin (NTS) and its primary receptor NTSR1 are implicated in cancer progression. Aberrant expression of NTS/NTSR1 contributes to the proliferation glioblastoma cells; however, mechanism is not fully understood.Microarray real-time PCR were performed identify NTS-regulated micro (mi)RNAs. The targets miRNAs identified by luciferase assays immunoblot analysis. c-Myc binding sites miR-29b-1 cyclin-dependent kinase (CDK)4 promoters through chromatin immunoprecipitation assay. Cell was...
Vitamin E intake has been implicated in reduction of bladder cancer risk. However, the mechanisms remain elusive. Here we reported that δ-tocotrienol (δ-T3), one vitamin isomers, possessed most potent cytotoxic capacity against human cells, compared with other isomers. δ-T3 inhibited cell proliferation and colonogenicity through induction G1 phase arrest apoptosis. Western blotting assay revealed increased expression levels cycle inhibitors (p21, p27), pro-apoptotic protein (Bax) suppressed...
Applications of sugar-containing polymers in lectin recognition, bacterial adhesion, hydrogels, bioimaging, and drug gene delivery.
Background Apoptosis caused by endoplasmic reticulum ( ER ) stress contributes to atherothrombosis, the underlying cause of cardiovascular disease CVD ). T ‐cell death‐associated gene 51 TDAG51 ), a member pleckstrin homology‐like domain family, is induced stress, causes apoptosis when overexpressed, and present in lesion‐resident macrophages endothelial cells. Methods Results To study role atherosclerosis, male mice deficient apolipoprotein E −/− / ApoE were generated showed reduced...
MicroRNAs (miRs) are widely involved in regulating tumor development and progression. miR-758-3p has been reported to suppress the progression of various cancer types, including hepatocellular carcinoma. However, whether a role bladder (BC) not previously reported, was thus investigated present study. It revealed that downregulated BC tissues cell lines. Transfection with mimics suppressed proliferation, migration invasion cells, inhibition had opposite effect. In terms underlying...
Heterochromatin protein 1γ (HP1γ), which binds to di- or trimethylated lysine 9 on histone H3 (H3K9), plays an important role in chromatin packaging and gene transcriptional regulation. Recently, HP1γ has been implicated cancer development. However, its clinical relevance functional non-small cell lung (NSCLC) remain elusive. In this study, we found that expression was elevated NSCLC samples at the messenger RNA (mRNA) level compared adjacent normal tissues. a cohort of 108 patients,...