A5064861723- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Historical Geography and Cartography
- Sarcoma Diagnosis and Treatment
- Historical Astronomy and Related Studies
- Chronic Myeloid Leukemia Treatments
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Institute of Hematology & Blood Diseases Hospital
2024-2025
Isolated 20q deletion [del(20q)] is a recurrent favorable abnormality in myelodysplastic syndrome (MDS) and may cause of the ASXL1 gene. Meanwhile, mutations are also common individuals with MDS. This study aimed to describe biological clinical implications newly diagnosed MDS patients isolated del(20q). Gene mutation copy number alterations 178 del(20q) were analyzed using DNA next generation sequencing. Twenty-five (14%) found have mutations, which exhibited lower absolute neutrophil...
We investigated data from 180 consecutive patients with myelodysplastic/myeloproliferative neoplasms SF3B1 mutation and thrombocytosis (MDS/MPN-SF3B1-T) who were diagnosed according to the 2022 World Health Organization (WHO) classification of myeloid identify covariates associated survival. At a median follow-up 48 months (95% confidence interval [CI] 35-61 months), survival was 69 CI 59-79 months). Patients bone marrow ring sideroblasts (RS) < 15% had shorter overall (OS) than did those RS...
<title>Abstract</title> GATA1 is one of critical transcription factors for megakaryopoiesis and platelet production. Our study aimed to explore the correlations between expression dysmegakaryopoiesis in myelodysplastic syndromes (MDS). Data blood cell counts, cytogenetics <italic>TP53</italic> mutation status from 90 MDS patients at diagnosis were collected. Firstly, we assessed level megakaryocytes by performing immunohistochemical staining on paraffin-embedded bone marrow biopsy sections...