A5053775464- Glycosylation and Glycoproteins Research
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Neuroendocrine regulation and behavior
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Stress, Anesthesia, and Immune Response
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Cell Adhesion Molecules Research
- Protein Kinase Regulation and GTPase Signaling
- Electrolyte and hormonal disorders
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Angiogenesis and VEGF in Cancer
- Neonatal Respiratory Health Research
- Ocular Oncology and Treatments
- Veterinary Oncology Research
- Neuropeptides and Animal Physiology
- Inflammatory mediators and NSAID effects
- Receptor Mechanisms and Signaling
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Galectins and Cancer Biology
Centro Científico Tecnológico - San Juan
2016-2024
National University of Quilmes
2015-2024
Universidad de Oviedo
2023-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
1996-2023
Hospital El Cruce
2022
Universitat Autònoma de Barcelona
1986-2019
Molecular Oncology (United States)
1999-2018
University of Buenos Aires
1992-2013
Centro de Ingeniería Genética y Biotecnología
2008-2013
Mexican Social Security Institute
1996-2010
Abstract Protein Kinase (casein kinase 2, CK2) is a serine-threonine that frequently dysregulated in many human tumors. Therefore we hypothesized peptides capable of binding to the CK2 acidic domain may exhibit potential anticancer properties. By screening random cyclic peptide phage display library, have identified novel peptide, P15, abrogated phosphorylation by blocking substrate vitro. To verify its antineoplastic effect, P15 was fused cell-penetrating derived from HIV-Tat protein....
Rho GTPases play a key role in the regulation of multiple essential cellular processes, including actin dynamics, gene transcription and cell cycle progression. Aberrant activation Rac1, member family small GTPases, is associated with tumorigenesis, cancer progression, invasion metastasis. Particularly, Rac1 overexpressed hyperactivated highly aggressive breast cancer. Thus, appears to be promising relevant target for development novel anticancer drugs. We identified inhibitor ZINC69391...
Abstract1E10 is an anti-idiotype murine monoclonal antibody (Ab2 MAb) specific to Ab1 MAb which reacts with NeuGc-containing gangliosides, sulfatides and antigens expressed in some human tumors. Preparations containing this Ab2 were capable induce a strong anti-metastatic effect tumor-bearing mice. We conducted Phase I clinical trial evaluate the toxicity humoral immune response elicited by 1E10 vaccine patients small cell lung cancer (SCLC). Eligible those who after received chemotherapy...
Abstract Background Cervical cancer is now considered the second leading cause of death among women worldwide, and its incidence has reached alarming levels, especially in developing countries. Similarly, high grade squamous intraepithelial lesion (HSIL), precursor stage for cervical cancer, represents a growing health problem younger as HSIL management regimes that have been developed are not fully effective. From etiological point view, presence Human Papillomavirus (HPV) demonstrated to...
Divergent selection stemming from environmental variation may induce local adaptation and ecological speciation whereas gene flow might have a homogenizing effect. Gene among populations using different environments can be reduced by geographical distance (isolation-by-distance) or divergent resource use (isolation-by-ecology). We tested for encountered phenotypic genetic divergence Spanish crossbills utilizing species of co-occurring pine trees as their food resource. Morphological, vocal...
The acyl-CoA synthetase 4 (ACSL4), which esterify mainly arachidonic acid (AA) into acyl-CoA, is increased in breast, colon and hepatocellular carcinoma. transfection of MCF-7 cells with ACSL4 cDNA transforms the a highly aggressive phenotype controls both lipooxygenase-5 (LOX-5) cyclooxygenase-2 (COX-2) metabolism AA, suggesting causal role tumorigenesis. We hypothesized that ACSL4, LOX-5 COX-2 may constitute potential therapeutic targets for control tumor growth. Therefore, aim this study...
Telomerase is a highly specialized reverse transcriptase (RT) and the maintenance of telomeric length determined by this specific enzyme. The human holoenzyme telomerase ribonucleoprotein composed catalytic subunit, hTERT, an RNA component, hTR, group associated proteins. normally expressed in embryonic cells repressed during adulthood. enzyme reexpressed around 85% solid tumors. This observation makes it potential target for developing drugs that could be developed therapeutic purposes....
AbstractConventional treatment of non-small cell lung cancer (NSCLC) has apparently reached a plateau effectiveness in improving the survival patients. For that reason search for new therapeutic strategies this type tumor is justified. 1E10 an anti-idiotype murine monoclonal antibody (Ab2 MAb) specific to P3 Ab1 MAb, which reacts with NeuGc-containing gangliosides, sulfatides and antigens expressed some tumors, including those from lung. We report aluminum hydroxide-precipitated MAb 34 stage...
CIGB-300, formerly known as P15-tat, is a proapoptotic peptide with established antiproliferative activity in vitro and antitumoral vivo. This hypothesis-driven was initially selected for its ability to impair the CK2-mediated phosphorylation one of substrates through direct binding conserved acidic phosphoaceptor domain. However, actual vivo target(s) on human cancer cells among hundreds CK2 well subsequent events that lead apoptosis tumor remains be determined. In this work, we identified...
Abstract The antitumor efficacy of the CK2 inhibitors so far described has not been extensively evaluated in cancer animal models. We have previously demonstrated that a proapoptotic cyclic peptide termed P15 delivered into cells by Tat Cell Penetrating Peptide was able to abrogate CK2‐mediated phosphorylation and induce tumor regression when injected directly solid tumors mice. Here we explored effect systemic administration P15‐Tat consecutive 5‐day schedule through either intraperitoneal...
The N-glycolylated ganglioside NeuGc-GM3 has been described in solid tumors such as breast carcinoma, nonsmall cell lung cancer, and melanoma, but is usually not detected normal human cells. Our aim was to evaluate the presence of pediatric neuroectodermal by immunohistochemistry. Twenty-seven archival cases neuroblastoma Ewing sarcoma family (ESFT) were analyzed. Formalin-fixed, paraffin-embedded tumor samples cut into 5 μm sections. monoclonal antibody 14F7, a mouse IgG1 that specifically...
Abstract: Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly failure of existing therapies. Deregulation small GTPases signaling, in particular Rac1 activity, plays a key role invasive phenotype gliomas. Here we report effect ZINC69391, specific inhibitor developed our group, on human glioma cell lines LN229 and U-87 MG. ZINC69391 is able interfere with interaction Dock180, relevant activator...