A5048698878- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- Immunotherapy and Immune Responses
- Maternal and fetal healthcare
- HIV Research and Treatment
- Antimicrobial Peptides and Activities
- Pregnancy and preeclampsia studies
- Immune Response and Inflammation
- Bacterial Infections and Vaccines
- vaccines and immunoinformatics approaches
- RNA Interference and Gene Delivery
- Pneumonia and Respiratory Infections
- Mass Spectrometry Techniques and Applications
- Toxoplasma gondii Research Studies
- Peptidase Inhibition and Analysis
- Advanced Proteomics Techniques and Applications
- Maternal and Perinatal Health Interventions
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Neuropeptides and Animal Physiology
- Sepsis Diagnosis and Treatment
- Ruminant Nutrition and Digestive Physiology
- Public Health and Environmental Issues
- Aquaculture disease management and microbiota
Secretaría Nacional de Ciencia, Tecnología e Innovación
2017-2025
Saint Thomas Hospital
2014-2025
Hamad General Hospital
2024
Qatar Airways (Qatar)
2024
Universidad de Panamá
2022
Centro de Ingeniería Genética y Biotecnología
2009-2019
Universidad Juárez del Estado de Durango
2011-2016
Complejo Hospitalario Dr. Arnulfo Arias Madrid
2014
Instituto de Salud del Estado de México
2014
Instituto Nacional de Salud del Niño
2014
In a phase 1/2 study, maternal respiratory syncytial virus vaccine candidate (RSVPreF3) demonstrated an acceptable safety profile and efficiently increased RSV-specific humoral immune responses in non-pregnant women.In this 2 observer-blind, placebo-controlled, randomized clinical trial (NCT04126213), the of RSVPreF3 (60 or 120 µg), administered during late second third trimester, was evaluated 213 18- to 40-year-old healthy pregnant women through 6 months postdelivery their offspring...
Abstract Protein Kinase (casein kinase 2, CK2) is a serine-threonine that frequently dysregulated in many human tumors. Therefore we hypothesized peptides capable of binding to the CK2 acidic domain may exhibit potential anticancer properties. By screening random cyclic peptide phage display library, have identified novel peptide, P15, abrogated phosphorylation by blocking substrate vitro. To verify its antineoplastic effect, P15 was fused cell-penetrating derived from HIV-Tat protein....
In this phase 3 trial of an investigational maternal respiratory syncytial virus prefusion F protein-based vaccine (RSVPreF3-Mat), a higher rate preterm birth was observed in the (6.8%) versus placebo group (4.9%). Trial enrollment and vaccination were stopped. Results investigations into safety signal reported previously. Here, we describe end-of-trial efficacy, immunogenicity, results. Women 18-49 years old randomized 2:1 to receive one dose RSVPreF3-Mat (n=3557) or (n=1771) at 240/7-340/7...
Abstract Background SARS-CoV-2 infection during pregnancy is associated with adverse maternal effects, but its impact on infant’s immune development not well defined. Using transcriptional profiles we analyzed the of SARS-CoV2 and/or vaccination in pregnant people and their infants longitudinally Transcriptome changes Modular analysis compared healthy uninfected controls. Red dot: overexpression, blue underexpression, white/empty space no difference vs controls Methods Multicenter...
Abstract The antitumor efficacy of the CK2 inhibitors so far described has not been extensively evaluated in cancer animal models. We have previously demonstrated that a proapoptotic cyclic peptide termed P15 delivered into cells by Tat Cell Penetrating Peptide was able to abrogate CK2‐mediated phosphorylation and induce tumor regression when injected directly solid tumors mice. Here we explored effect systemic administration P15‐Tat consecutive 5‐day schedule through either intraperitoneal...
We have demonstrated that the peptide L-2 designed from an alanine scanning of Limulus -derived LALF32-51 region is a potential candidate for anticancer therapy and its cell-penetrating capacity associated useful property. By modification in primary structure L-2, second-generation (CIGB-552) was developed. However, molecular mechanism underlying cytotoxic activity remains partially unknown. In this study, it shown CIGB-552 increases levels COMMD1, protein involved copper homeostasis, sodium...
Increasing the diversity of peptide cyclization methods is an effective way accessing new types macrocyclic chemotypes featuring a wide variety ring sizes and topologies. Multicomponent reactions (MCRs) are processes capable generating great levels molecular complexity at low synthetic cost. In attempt to further exploit MCRs in field cyclopeptides, we describe bidirectional multicomponent approach for synthesis N-alkylated peptides varied sequences cross-linking positions. The process...
A combination of antiviral drugs known as antiretroviral therapy (ART) has shown effectiveness against the human immunodeficiency virus (HIV). ART markedly decreased mortality and morbidity among HIV-infected patients, having even reduced HIV transmission. However, an important current disadvantage, resistance development, remains to be solved. Hope is focused on developing cellular targets. This strategy expected prevent emergence viral resistance. In this study, using a comparative...
Internal rearrangement involving the loss of C-terminal amino acid residue upon collision-induced dissociation (CID) or metastable decomposition was studied for protonated peptides. To investigate structural characteristics peptides responsible this rearrangement, a series synthetic were prepared and subjected to B/E-linked scan tandem mass spectrometric analyses using four-sector instrument. The results showed that position basic in peptide sequence its basicity have significant influence...
Different strategies have been used to increase the immunogenicity of an antigenic HIV peptide as a vaccine candidate. The selected B-cell epitope comprises 15 amino acids (317-331) V3 region HIV-1, JY1 isolate (subtype D), in tandem with T-helper corresponding 830-844 tetanus toxoid. Several presentations, including oligomerization, multiple dendrimers, and conjugation dextran beads or other macromolecular carriers, synthesized evaluated. Murine sera from different presentations compared...
CIGB‐300 is a novel anticancer peptide that impairs the casein kinase 2‐mediated phosphorylation by direct binding to conserved phosphoacceptor site on their substrates. Previous findings indicated inhibits tumor cell proliferation in vitro and induces growth delay vivo cancer animal models. Interestingly, we had previously demonstrated putative oncogene B23/nucleophosmin (NPM) major intracellular target for sensitive human lung line. However, ability of this B23/NPM cells with differential...
Accumulation of the COMMD1 protein as a druggable pharmacology event to target cancer cells has not been evaluated so far in animal models. We have previously demonstrated that second-generation peptide, with cell-penetrating capacity, termed CIGB-552, was able induce apoptosis mediated by stabilization COMMD1. Here, we explore antitumor effect subcutaneous administration CIGB-552 therapeutic schedule. Outstandingly, significant delay tumor growth observed at 0.2 and 0.7 mg/kg (p < 0.01) or...
ABSTRACT Previous studies have shown that cyclic peptides corresponding to residues 35 52 of the Limulus antilipopolysaccharide (anti-LPS) factor (LALF) bind and neutralize LPS-mediated in vitro vivo activities. Therapeutic approaches based on agents which LPS activities are particularly attractive because these substances directly block primary stimulus for entire proinflammatory cytokine cascade. Here we describe new LALF 31–52 peptide, other than its binding ability. Surprisingly,...
To date, many technologies have been developed to increase efficiency in aquaculture, but very few successful biotechnology molecules arrived on the market. In this context, marine has an opportunity develop products improve output of fish aquaculture. Published vivo studies action pituitary adenylate cyclase-activating polypeptide (PACAP) are scarce. Recently, our group, for first time, demonstrated biological role neuropeptide administrated by immersion baths growth and development larval...