A5040608645- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Bacterial Infections and Vaccines
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Hepatitis Viruses Studies and Epidemiology
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neonatal and Maternal Infections
- Viral Infections and Immunology Research
- Intramuscular injections and effects
- Animal Virus Infections Studies
- Streptococcal Infections and Treatments
- Infectious Encephalopathies and Encephalitis
- Pharmacovigilance and Adverse Drug Reactions
- Immunodeficiency and Autoimmune Disorders
- Peripheral Neuropathies and Disorders
- Congenital Anomalies and Fetal Surgery
- COVID-19 Clinical Research Studies
- Data-Driven Disease Surveillance
- Kawasaki Disease and Coronary Complications
- Virology and Viral Diseases
- Neonatal Respiratory Health Research
- Herpesvirus Infections and Treatments
Murdoch Children's Research Institute
2016-2025
Royal Children's Hospital
2013-2025
The University of Melbourne
2014-2025
Monash Children’s Hospital
2015-2024
Monash University
2014-2024
Melbourne Health
2021-2024
Monash Health
2013-2024
Government of Western Australia Department of Health
2019-2024
Australian Government
2019-2024
University of Auckland
2024
OBJECTIVES. The primary aims of this study were to determine the volume blood submitted for culture in routine clinical practice and establish proportion cultures with a inadequate reliable detection bacteremia. METHODS. volumes samples from infants children up 18 years age measured over 6-month period. Blood deemed adequate submissions if they contained an appropriate (age-related) correct bottle type. During study, educational intervention designed increase was undertaken. RESULTS. 1358...
Preterm birth is commonly defined as any before 37 weeks completed of gestation. An estimated 15 million infants are born preterm globally, disproportionately affecting low and middle income countries (LMIC). It contributes directly to one neonatal deaths annually a significant contributor childhood morbidity. However, in many clinical settings, the information available calculate gestation varies widely. Accurate dating last menstrual period (LMP), well access ultrasonographic evaluation...
To describe the epidemiology of neonatal infection over past decade in UK units.Retrospective analysis prospectively collected surveillance network data from 2005 to 2014.30 units UK.Newborns on participating who had a positive blood, cerebrospinal fluid or urine culture and were treated with at least 5 days appropriate antibiotics.2171 episodes 1922 infants recorded. The incidence was 6.1/1000 live births 48.8/1000 admissions (2.9 23.5 respectively if coagulase-negative staphylococci (CoNS)...
The Global COVID Vaccine Safety (GCoVS) Project, established in 2021 under the multinational Data Network™ (GVDN®), facilitates comprehensive assessment of vaccine safety. This study aimed to evaluate risk adverse events special interest (AESI) following COVID-19 vaccination from 10 sites across eight countries. Using a common protocol, this observational cohort compared observed with expected rates 13 selected AESI neurological, haematological, and cardiac outcomes. Expected were obtained...
: Rotavirus vaccines were introduced into the funded Australian National Immunization Program (NIP) in July 2007. Due to purchasing arrangements, individual states and territories chose either a 2-dose RV1 (Rotarix, GSK) regimen or 3-dose RV5 (Rotateq, Merck/CSL) regimen. This allowed comparison of both similar populations with high infant vaccination coverage.: Admission rotavirus identification data from major pediatric hospitals 3 (2 using RV5, 1 RV1), together state-based hospitalization...
BackgroundThere are limited data comparing the performance of two commercially available interferon gamma (IFN-γ) release assays (IGRAs) for diagnosis tuberculosis (TB) in children. We compared QuantiFERON-TB gold In Tube (QFT-IT), T-SPOT.TB and tuberculin skin test (TST) children at risk latent TB infection or disease.Methods FindingsThe results both IGRAs were with assigned by TST-based criteria assessed relation to contact history. Results from TST least one assay 96 100 Agreement between...
The diagnosis of latent Mycobacterium tuberculosis (MTB) infection with a tuberculin skin test (TST) in children is complicated by the potential influence prior exposure to Bacille Calmette Geurin (BCG) vaccination or environmental mycobacteria. A whole blood assay has recently been developed quantitatively measure interferon gamma (IFN-gamma) production lymphocytes specific MTB antigens ESAT-6 and CFP-10, but its use assessment limited. study was undertaken compare performance IFN-gamma TST...
Background. Estimates of the risk intussusception (IS) associated with currently licensed rotavirus vaccines (RV1 [Rotarix; GSK] and RV5 [RotaTeq; Merck]) diverge. Contemporaneous introduction both in Australia enabled a population-based assessment risk. Methods. Confirmed cases IS infants aged 1 to <12 months were identified from national hospitalization databases, supplemented by active hospital-based surveillance, July 2007 through June 2010. Vaccination histories verified Australian...
A strategy of administering a neonatal rotavirus vaccine at birth to target early prevention gastroenteritis may address some the barriers global implementation vaccine.
Staphylococcus aureus bacteremia (SAB) in children causes significant morbidity and mortality, but the epidemiology is not well characterized.To describe of SAB adolescents younger than 18 years from Australia New Zealand.A prospective cohort study, using data Australian Zealand Cooperative on Outcomes Staphylococcal Sepsis for 1153 with birth to less pediatric general hospitals across Zealand, collected between January 1, 2007, December 31, 2012. Multivariate analysis was performed identify...
Immunization in pregnancy provides a promising contribution to globally reducing neonatal and under-five childhood mortality morbidity. Thorough assessment of benefits risks for the primarily healthy pregnant women their unborn babies is required. The GAIA project was formed response call World Health Organization concerted approach actively monitor safety vaccines immunization programs. aims improve quality outcome data from clinical vaccine trials with specific focus on needs requirements...
In a phase 1/2 study, maternal respiratory syncytial virus vaccine candidate (RSVPreF3) demonstrated an acceptable safety profile and efficiently increased RSV-specific humoral immune responses in non-pregnant women.In this 2 observer-blind, placebo-controlled, randomized clinical trial (NCT04126213), the of RSVPreF3 (60 or 120 µg), administered during late second third trimester, was evaluated 213 18- to 40-year-old healthy pregnant women through 6 months postdelivery their offspring...
This is a revision of the online November 2021 Brighton thrombosis with thrombocytopenia syndrome (TTS) case definition and new Collaboration for vaccine-induced immune (VITT). These definitions are intended use in clinical trials post-licensure pharmacovigilance activities to facilitate safety data comparability across multiple settings. They not guide management. The were developed by group subject matter process experts as part Coalition Epidemic Preparedness Innovations (CEPI)-funded...
We sought to determine the range and extent of neurologic complications due pandemic influenza A (H1N1) 2009 infection (pH1N1'09) in children hospitalized with influenza.Active hospital-based surveillance 6 Australian tertiary pediatric referral centers between June 1 September 30, 2009, for aged <15 years laboratory-confirmed pH1N1'09.A total 506 pH1N1'09 were hospitalized, whom 49 (9.7%) had complications; median age 4.8 (range 0.5-12.6 years) compared 3.7 (0.01-14.9 those without...
Background. RotaTeq vaccine was introduced into the Australian National Immunisation Program in 2007. This study identified and characterised rotavirus strains excreted by infants who presented with symptoms of gastroenteritis following recent vaccination. Methods. Fecal samples (N = 61) from children developed vaccination were forwarded to Rotavirus Surveillance (ARSP). RotaTeq-positive genotyped regions VP3, VP4, VP6, VP7 genes sequenced. Also, 460 rotavirus-positive ARSP routine...
The Global COVID Vaccine Safety (GCoVS) project was established in 2021 under the multinational Data Network (GVDN) consortium to facilitate rapid assessment of safety newly introduced vaccines. This study analyzed data from GVDN member sites on background incidence rates conditions designated as adverse events special interest (AESI) for COVID-19 vaccine monitoring.Eleven global obtained national or regional healthcare databases using standardized methods. Incident 13 pre-defined AESI were...
Background. Nosocomial outbreaks of Pseudomonas aeruginosa in pediatric hospitals frequently involve neonates and immunosuppressed patients can cause significant morbidity mortality. Objective. To describe the investigation a multidrug-resistant P. outbreak oncology ward at Royal Children's Hospital, Melbourne, Australia. Design methods. Specimens were collected from infected environment. Bacterial isolates characterized by antibiotic susceptibility patterns bacterial DNA fingerprinting...
Background: Necrotizing enterocolitis (NEC) is an acute abdominal emergency of unknown etiology predominantly affecting preterm infants. We describe a cluster NEC in level III NICU involving 15 infants over 6-month period. Cohorting and stringent infection control measures were associated with termination the cluster. A case-control study was used to investigate potential risk factors development NEC. Methods: Stool samples collected from 55 (10 45 non-NEC controls). Enteric pathogens...