A5102021026- Bacterial Infections and Vaccines
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Cervical Cancer and HPV Research
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Infectious Encephalopathies and Encephalitis
- COVID-19 Impact on Reproduction
- Hepatitis B Virus Studies
- Infective Endocarditis Diagnosis and Management
- Vector-Borne Animal Diseases
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- Reproductive tract infections research
- Herpesvirus Infections and Treatments
- Neonatal Respiratory Health Research
- Immune responses and vaccinations
- Vector-borne infectious diseases
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Child and Adolescent Health
The University of Adelaide
2016-2025
Women's and Children's Health Network
2016-2025
Women's and Children's Hospital
2015-2024
Royal Children's Hospital
2012-2023
Hospital Selayang
2023
Monash University
2012-2022
Robinson Memorial Hospital
2014-2022
Monash Alfred Psychiatry Research centre
2022
The Alfred Hospital
2022
In-Q-Tel
2021
Respiratory syncytial virus (RSV) is the dominant cause of severe lower respiratory tract infection in infants, with most cases concentrated among younger infants.
The meningococcal group B vaccine 4CMenB is a new, recombinant protein-based that licensed to protect against invasive disease. However, its role in preventing transmission and, therefore, inducing population (herd) protection uncertain.
The bacille Calmette-Guérin (BCG) vaccine has immunomodulatory "off-target" effects that have been hypothesized to protect against coronavirus disease 2019 (Covid-19).
Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020-2021. Sera were collected pre-vaccination ~14 ~180 days post-vaccination haemagglutination inhibition assay against egg-grown equivalent cell-grown viruses. Responses to vaccination compared by the number prior vaccinations. Baseline sera available for 595 HCW 2020 1031...
<h3>Context</h3>In the ongoing influenza pandemic, a safe and effective vaccine against 2009 A(H1N1) is needed for infants children.<h3>Objective</h3>To assess immunogenicity safety of in children.<h3>Design, Setting, Participants</h3>Randomized, observer-blind, age-stratified, parallel group study assessing 2 doses an inactivated, split-virus 370 healthy children aged 6 months to less than 9 years living Australia.<h3>Intervention</h3>Intramuscular injection 15 μg or 30 hemagglutinin...
During the 2009 H1N1 influenza pandemic, Australian public health officials closed schools as a strategy to mitigate spread of infection. This article examines school communities' understanding of, and participation in, closures beliefs values which underpinned responses closures. We interviewed four principals, 25 staff, 14 parents 13 students in five one city were either fully or partially during pandemic. Drawing on Thompson et al's ethical framework for pandemic planning, we show that...
Acellular vaccines against Bordetella pertussis were introduced in Australia 1997. By 2000, these had replaced whole-cell vaccines. During 2008-2012, a large outbreak of occurred. this period, 30% (96/320) B. isolates did not express the vaccine antigen pertactin (Prn). Multiple mechanisms Prn inactivation documented, including IS481 and IS1002 disruptions, variation within homopolymeric tract, deletion prn gene. The mechanism lack expression 16 (17%) could be determined at sequence level....
There are few longitudinal studies of seasonal influenza-associated neurological disease (IAND) and none from the Southern Hemisphere.We extracted prospectively acquired Australian surveillance data 2 nested within Paediatric Active Enhanced Disease Surveillance (PAEDS) network: Influenza Complications Alert Network (FluCAN) study Childhood Encephalitis (ACE) between 2013 2015. We described clinical features severity IAND in children, including encephalitis/encephalopathy (IAE). calculated...
From 2014 to 2017, the World Health Organization convened a working group evaluate influenza disease burden and vaccine efficacy inform estimates of maternal immunization program impact. The evaluated existing systematic reviews relevant primary studies, conducted four new reviews. There was strong evidence that prevented illness in pregnant women their infants, although data on severe prevention were lacking. limited number studies reporting incidence infants under six months had highly...
Abstract Background We aimed to determine the contemporary causes, clinical features, and short-term outcome of encephalitis in Australian children. Methods prospectively identified children (≤14 years age) admitted with suspected at 5 major pediatric hospitals nationally between May 2013 December 2016 using Paediatric Active Enhanced Disease Surveillance (PAEDS) Network. A multidisciplinary expert panel reviewed cases categorized them published definitions. Confirmed were into etiologic...