Cristina Epalza
A5051886488- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Kawasaki Disease and Coronary Complications
- HIV/AIDS Research and Interventions
- Neonatal and Maternal Infections
- SARS-CoV-2 and COVID-19 Research
- Streptococcal Infections and Treatments
- Respiratory Support and Mechanisms
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Antibiotic Use and Resistance
- Sepsis Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Bacterial Infections and Vaccines
- COVID-19 and Mental Health
- Parvovirus B19 Infection Studies
- Hemoglobinopathies and Related Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Coronary Artery Anomalies
- COVID-19 Impact on Reproduction
- Cytomegalovirus and herpesvirus research
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 detection and testing
- Tuberculosis Research and Epidemiology
Hospital Universitario 12 De Octubre
2017-2025
Research Institute Hospital 12 de Octubre
2018-2025
Centre for Biomedical Network Research on Rare Diseases
2025
Instituto de Salud Carlos III
2021-2025
Madrid Health Service
2023-2025
PENTA Foundation
2025
Universidad Complutense de Madrid
2019-2023
University of Padua
2023
Panagiotis & Aglaia Kyriakou Children's Hospital
2023
National and Kapodistrian University of Athens
2023
Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children Madrid, SpainAs the pandemic coronavirus disease spreads, new data emerge understanding improves.2][3] The epicenter epidemic has displaced to Europe.The first case Spain was declared on January 31, 2020, Madrid region February 27, 2020.Methods | With aim obtaining an overview proportion confirmed cases among those tested severity children, a registry performed from March 2, 16, by pediatricians 30 secondary tertiary...
Improving the quality of hospital antibiotic use is a major goal WHO's global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification could facilitate simple stewardship interventions that are widely applicable globally. We aimed present data on patterns paediatric AWaRe be used for local national interventions.1-day point prevalence survey prescription were combined from two independent networks: Global Antimicrobial...
Abstract Some clusters of children with a multisystem inflammatory syndrome (MIS-C) associated severe acute respiratory coronavirus 2 (SARS-CoV-2) infection have been reported. We describe the epidemiological and clinical features MIS-C in Spain. is potentially condition that presents recent SARS-CoV-2 infection.
The occurrence of an unusual number group B streptococcal (GBS) infections in HIV-exposed uninfected (HEU) infants who were followed our center prompted this study. objective study was to describe and compare the incidence clinical presentation GBS born HIV-infected -uninfected mothers.All cases invasive between 2001 2008 identified from database HEU microbiology laboratory records. medical charts all with infection reviewed.GBS described for 5 (1.55%) 322 mothers delivered center. during...
Abstract The aim of this transversal study was to describe the virological and immunological features HIV-infected youths transferred from pediatric adult care units since 1997 vs. non-transferred patients Madrid Cohort children adolescents in Spain. We included 106 184 under clinical follow-up 17 public hospitals by end December 2017. Virological outcomes were compared patients. ART drug resistance mutations HIV-variants analyzed all subjects with available pol genotypes and/or genotypic...
Background: Cytomegalovirus (CMV) is the leading cause of congenital infection worldwide. Up to 15%–20% infected newborns will develop long-term sequelae such as hearing loss and neurologic abnormalities. The aim this study was investigate prevalence CMV (cCMV) associated clinical abnormalities in Spain. Methods: A prospective screening for cCMV by viral load saliva performed. Saliva samples were obtained within first 72 hours life a maternity ward Madrid (Spain), during 1-year period. All...
We aimed to identify the spectrum of disease in children with COVID-19, and risk factors for admission paediatric intensive care units (PICUs). conducted a multicentre, prospective study SARS-CoV-2 infection 76 Spanish hospitals. included COVID-19 or multi-inflammatory syndrome (MIS-C) younger than 18 years old, attended during first year pandemic. enrolled 1200 children. A total 666 (55.5%) were hospitalised, 123 (18.4%) required PICU. Most frequent major clinical syndromes cohort mild...
To identify a diagnostic blood transcriptomic signature that distinguishes multisystem inflammatory syndrome in children (MIS-C) from Kawasaki disease (KD), bacterial infections, and viral infections.
In this prospective cohort study with 2326 hospitalized children and young people coronavirus disease 2019 in Spain Colombia, 36.4% had comorbidities. Asthma, recurrent wheezing, chronic neurological, cardiac pulmonary diseases significantly increased the risk of severe outcomes such as death, mechanical ventilation intensive care unit admission. The incremental additional comorbidities underscores importance targeted vaccination strategies for vulnerable populations.
In this phase 3 trial of an investigational maternal respiratory syncytial virus prefusion F protein-based vaccine (RSVPreF3-Mat), a higher rate preterm birth was observed in the (6.8%) versus placebo group (4.9%). Trial enrollment and vaccination were stopped. Results investigations into safety signal reported previously. Here, we describe end-of-trial efficacy, immunogenicity, results. Women 18-49 years old randomized 2:1 to receive one dose RSVPreF3-Mat (n=3557) or (n=1771) at 240/7-340/7...
We aimed to identify risk factors causing critical disease in hospitalized children with COVID-19 and build a predictive model anticipate the probability of need for care.We conducted multicenter, prospective study SARS-CoV-2 infection 52 Spanish hospitals. The primary outcome was care. used multivariable Bayesian estimate needing care.The enrolled 350 from March 12, 2020, July 1, 2020: 292 (83.4%) 214 (73.7%) were considered have relevant COVID-19, whom 24.2% required Four major clinical...
This phase 1b study evaluated the pharmacokinetics, safety, and antiviral effects of respiratory syncytial virus (RSV)-specific fusion inhibitor JNJ-53718678 (JNJ-8678) in hospitalized RSV-infected patients aged > 1 to ≤24 months.Patients categorized by age (cohort 1: ≥6 months; cohort 2: ≥3 < 6 3: 3 months) were randomized oral JNJ-8678 or placebo once daily for 7 days. Dose increases followed data review committee recommendations 2/6/8/9 mg/kg; 1.5/4.5/6 1/3/5 mg/kg). Cohort included a 9...
Fever without source (FWS) in infants is a frequent cause of consultation at the emergency department, and emergence SARS-CoV-2 could affect approach to those infants. The aim this study define clinical characteristics rates bacterial coinfections < 90 days with FWS as first manifestation infection. This cross-sectional under age positive SARS-CoV2 PCR nasopharyngeal swab/aspirate, attended departments 49 Spanish hospitals (EPICO-AEP cohort) from March 1 June 26, 2020. Three hundred...
Abstract Introduction Endemic coronaviruses have been found in acute bronchiolitis, mainly as a coinfecting virus. Severe respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has responsible for illness hospitalized children. The characteristics of patients with bronchiolitis not extensively described. Methods Cross‐sectional study and SARS‐CoV‐2 infection enrolled prospective multicenter cohort children COVID‐19 Spain from March 1, 2020 to February 28, 2021. Results Twelve 666 infected who...
Abstract Background Safe and effective respiratory syncytial virus (RSV) vaccines remain elusive. This was a phase I/II trial (NCT02927873) of ChAd155-RSV, an investigational chimpanzee adenovirus-RSV vaccine expressing 3 proteins (fusion, nucleoprotein, M2-1), administered to 12–23-month-old RSV-seropositive children followed up for 2 years after vaccination. Methods Children were randomized receive doses ChAd155-RSV or placebo (at 1:1 ratio) (days 1 31). Doses escalated from 0.5 × 1010...
To describe the etiology of community-acquired pneumonia (CAP) in hospitalized children Spain and analyze predictors etiology.The different etiological groups pediatric CAP are associated with clinical, radiographic, analytical data.Observational, multicenter, prospective study.This study included aged 1 month to 17 years CAP, who were between April 2012 May 2019.An extensive microbiological workup was performed. The parameters analyzed for three groups.Among 495 included, at least one...
Abstract Introduction Immune abnormalities have been described among youth with vertically acquired HIV (YWVH) despite antiretroviral treatment (ART). The CD4/CD8 ratio could be a useful prognostic marker. We assess immune activation and senescence in cohort of YWVH comparison to without HIV. Methods under suppressive ART were included compared group HIV‐negative donors (HD) matched by age sex, from September 2019 2020. Subset distribution expression activation, maturation, exhaustion...
Enteroviruses (EVs) and human parechoviruses (HPeVs) are a major cause of central nervous system (CNS) infection in young infants. They have been implicated neurodevelopmental delay, however limited data available. The aim this study is to describe the clinical outcome infants assess compare medium-term neurodevelopment following CNS infections caused by EV HPeV. A multicentre observational ambispective was conducted between May 2013 March 2018. Children under 3 months age with or HPeV...
The SARS-CoV-2 pandemic has caused an increase in antibiotic use different settings. We describe the prescribing prevalence, associated factors and trends, as well concomitant bacterial infections children hospitalized with COVID-19 or multisystemic inflammatory syndrome related to Spain.