A5102774261- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
- Mast cells and histamine
- Hematopoietic Stem Cell Transplantation
- Alcohol Consumption and Health Effects
- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Hematological disorders and diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis Viruses Studies and Epidemiology
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Immigration and Intercultural Education
- Viral-associated cancers and disorders
- Reproductive Physiology in Livestock
- Urologic and reproductive health conditions
- Viral gastroenteritis research and epidemiology
- Environmental Education and Sustainability
- Congenital Diaphragmatic Hernia Studies
- Religious and Theological Studies
Hospital General Dr. Manuel Gea Gonzalez
2025
Chapingo Autonomous University
2023
Universidad de Salamanca
2009-2022
Centro de Investigación del Cáncer
2009-2022
Instituto de Investigación Biomédica de Salamanca
2012-2022
Hospital Universitario Río Hortega
2002-2022
GlaxoSmithKline (United States)
2022
Centro de Investigación Biomédica en Red de Cáncer
2018-2020
Comillas Pontifical University
2020
Instituto de Salud Carlos III
2020
Here, we evaluate the sensitivity and specificity of a new 11-parameter flow cytometry (FCM) approach versus conventional cytology (CC) for detecting neoplastic cells in stabilized CSF samples from newly diagnosed aggressive B-cell non-Hodgkin's lymphoma (B-NHL) at high risk CNS relapse, using prospective, multicentric study design.Moreover, compared distribution different subpopulations leukocytes clinico-biologic characteristics CSF+ CSF-, patients, an attempt to define algorithms useful...
// Lourdes Martín-Martín 1 , Antonio López Belén Vidriales 2 María Dolores Caballero António Silva Rodrigues 3 Silvia Inês Ferreira 4 Margarida Lima 5 Sérgio Almeida 6 Berta Valverde 7 Pilar Martínez 8 Ana Ferrer 9 Jorge Candeias 10 Francisco Ruíz-Cabello 11 Josefa Marco Buadesa 12 Amparo Sempere 13 Neus Villamor 14 Alberto Orfao 1, * Julia Cancer Research Centre (IBMCC, USAL-CSIC), Institute for Biomedical of Salamanca (IBSAL) and Department Medicine Cytometry Service, University (USAL),...
Abstract Background Mastocytosis is a term used for heterogeneous group of disorders characterized by an abnormal proliferation and accumulation mast cells (MCs) in one or multiple tissues including skin, bone marrow, liver, spleen, lymph nodes, among others. Methods In recent years, multiparameter flow cytometric studies have shown that pathologic MCs from patients with mastocytosis display unique aberrant immunophenotypic characteristics as compared normal MCs. Results Among other...
Abstract A heterogeneous spectrum of immunophenotypic abnormalities have been reported in myelodysplastic syndromes (MDS). However, most studies are restricted to the analysis CD34 + cells and/or other major subsets − cells, frequently not exploring diagnostic and prognostic impact immunophenotyping. Methods: We propose for first time an score (IS) based on altered distribution features maturing/mature compartments bone marrow (BM) hematopoietic 56 patients with MDS that could contribute a...
Abstract To understand the molecular and neural mechanisms underlying alcohol addiction, many models ranging from vertebrates to invertebrates have been developed. In D rosophila melanogaster , behavioral paradigms assaying acute responses behaviors more closely modeling addiction emerged in recent years. However, both CAFÉ assay, similar a two‐bottle choice consumption as well conditioned odor preference, where ethanol is used reinforcer, are labor intensive low throughput. address this...
STAT3 and STAT5B (STAT3/STAT5B) mutations are the most common in T-cell large granular lymphocytic leukemia (T-LGLL) chronic lymphoproliferative disorders of NK cells (CLPD-NK), but their clinical impact remains unknown. We investigated frequency type STAT3/STAT5B FACS-sorted populations expanded T/NK-LGL from 100 (82 clonal; 6 oligoclonal; 12 polyclonal) patients, its relationship with disease features. Seventeen non-LGL T-CLPD patients 628 age-matched healthy donors were analyzed as...
Abstract Background Varicella zoster virus (VZV) reactivation typically presents as herpes zoster, but central nervous system (CNS) involvement is more prevalent in immunocompromised individuals. Methods This retrospective study, conducted from January 2023 to March 2024 at two hospitals, aimed characterize VZV CNS infections this population. Twenty-seven patients with active were included. Clinical data, cerebrospinal fluid (CSF) analysis, and treatment outcomes analyzed. Results The mean...
Abstract B‐cell chronic lymphocytic leukemia (B‐CLL) is a well‐defined clinical entity with heterogeneous molecular and cytogenetic features. Here, we analyze the impact of trisomy 12, del(13q), del(17p), del(11q) as determined by interphase fluorescence in situ hybridization analysis purified neoplastic B‐CLL cells on their immunophenotype, DNA ploidy status proliferative rate. Overall, 111 180 (62%) cases studied displayed one (50%) or more (12%) genetic abnormalities, del(13q) (35%) being...
Background: In the present study, we analyzed, at intracellular level, pattern of cytokine secretion by major CD4 + and CD8 strong+ peripheral blood (PB) T‐cell subsets in patients with chronic alcoholism, correlated it both ethanol (EtOH) intake status presence or not alcoholic liver disease. Methods: For that purpose, a total 30 patients, 10 without disease (AWLD group) 20 diagnosed cirrhosis (ALC) were studied. all cases, flow cytometric measurement expression interferon–γ (IFN‐γ),...
Abstract Background: Monoclonal B‐cell lymphocytosis (MBL) indicates <5 × 10 9 peripheral blood (PB) clonal B‐cells/L in healthy individuals. In most cases, MBL cells show similar phenotypic/genetic features to chronic lymphocytic leukemia cells—CLL‐like MBL—but little is known about non‐CLL‐like MBL. Methods: PB samples from 639 individuals (46% men/54% women) >40 years old (62 ± 13years) with normal lymphocyte counts (2.1 0.7 /L) were immunophenotyped using high‐sensitive flow...