Blanca Herrero
A5062836963- Childhood Cancer Survivors' Quality of Life
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
- Respiratory viral infections research
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Respiratory Support and Mechanisms
- Kawasaki Disease and Coronary Complications
- Hematopoietic Stem Cell Transplantation
- Breast Cancer Treatment Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer Treatment and Pharmacology
- Palliative Care and End-of-Life Issues
- Neuroblastoma Research and Treatments
- Biosimilars and Bioanalytical Methods
- Advanced Breast Cancer Therapies
- Neutropenia and Cancer Infections
- Acute Myeloid Leukemia Research
- Virus-based gene therapy research
- Immunodeficiency and Autoimmune Disorders
- Neonatal Health and Biochemistry
- Urinary Tract Infections Management
- Ethics in Clinical Research
- Immune Cell Function and Interaction
Hospital Infantil Universitario Niño Jesús
2012-2025
Instituto de Investigación Biomédica de Salamanca
2021-2025
Centro de Investigación del Cáncer
2021-2025
Universidad de Salamanca
2021-2025
Hospital Universitario de La Princesa
2024
Hospital General Universitario Gregorio Marañón
2020-2024
GEICAM – Spanish Breast Cancer Group
2024
Centro de Investigación Biomédica en Red de Cáncer
2021
Hospital Universitario Infanta Leonor
2021
Hospital del Niño
2013-2021
Abstract Some clusters of children with a multisystem inflammatory syndrome (MIS-C) associated severe acute respiratory coronavirus 2 (SARS-CoV-2) infection have been reported. We describe the epidemiological and clinical features MIS-C in Spain. is potentially condition that presents recent SARS-CoV-2 infection.
Celiac disease (CD) is a common disorder in children and adults. However, limited data are available when comparing differences between both populations.To prospectively evaluate compare the clinical histological features present at diagnosis cohort of celiac adults.Consecutive new cases diagnosed 2000 2006 were included (66 54 adults). The spectrum was categorized two groups: (a) typical (malabsorption, chronic diarrhea, or failure to thrive) (b) oligosymptomatic (abdominal pain, anemia,...
AIM:To evaluate the predictive value of tissue transglutaminase (tTG) antibodies for villous atrophy in adult and pediatric populations to determine if duodenal biopsy can be avoided.
Introduction Loss of B-cell aplasia (BCA) is a well-known marker functional loss CD19 CAR-T. Most relapses and BCA occur in the first months after CAR-T infusion. In addition, high tumor burden (HTB) has shown to have strong impact on relapse, especially CD19-negative. However, little known about late or relationship between pre-infusion patients infused with tisagenlecleucel for relapsed/refractory acute lymphoblastic leukemia. Therefore, optimal management yet be defined. Methods We...
We aimed to identify the spectrum of disease in children with COVID-19, and risk factors for admission paediatric intensive care units (PICUs). conducted a multicentre, prospective study SARS-CoV-2 infection 76 Spanish hospitals. included COVID-19 or multi-inflammatory syndrome (MIS-C) younger than 18 years old, attended during first year pandemic. enrolled 1200 children. A total 666 (55.5%) were hospitalised, 123 (18.4%) required PICU. Most frequent major clinical syndromes cohort mild...
Triple-negative breast cancer (TNBC) is highly responsive to neoadjuvant polychemotherapy regimens including anthracyclines, taxanes, and, more recently, carboplatin. However, there inadequate information on the individual contribution of each these agents global activity combinations, and use combinations up four drugs associated with relevant toxicity. Identifying single-drug in clinical setting challenging. We developed patient-derived xenografts (PDXs) from several chemotherapy-naïve...
We aimed to identify risk factors causing critical disease in hospitalized children with COVID-19 and build a predictive model anticipate the probability of need for care.We conducted multicenter, prospective study SARS-CoV-2 infection 52 Spanish hospitals. The primary outcome was care. used multivariable Bayesian estimate needing care.The enrolled 350 from March 12, 2020, July 1, 2020: 292 (83.4%) 214 (73.7%) were considered have relevant COVID-19, whom 24.2% required Four major clinical...
Despite the increasing number of central nervous system (CNS) tumour survivors, long-term (LT) sequelae remain a substantial burden on their health through various life stages. The aim our study was to evaluate late morbidity, health-related quality (HRQoL), self-esteem, functional status, adaptive behaviour, physical activity and social outcomes such as education, employment, relationship status possession driver's license, in addition role LT effects radiotherapy (RTx) these outcomes....
Background/Objectives: Despite the current international prognostic index for chronic lymphocytic leukemia (CLL) being widely accepted and broadly used, it does not consider kinetics of B-cell clone over time. Here, we investigated potential association between distinct features leukemic cells other immune in blood clonal B-cells CLL stage Binet A/Rai 0 (A/0) patients; Methods: Based on cell kinetics, 69 A/0 cases followed a median 105 months were classified as carrying stable (n = 53) vs....
To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part EPICO multicenter cohort study. We included with confirmed from Colombian and Spanish institutions to assess disease evolution outcomes. Cluster analysis was performed identify phenotypes. A total 2318 patients were (55% male, 36% infants). Five phenotype clusters emerged: 1 (26.5%): infants without comorbidities, low PICU admissions mortality; 2 (18.5%): respiratory high microorganism...
Background/Objectives: Immune effector cell-associated hematotoxicity (ICAHT) is a frequent adverse event after chimeric antigen receptor (CAR)-T cell therapy. Grade ≥ 3 thrombocytopenia occurs in around one-third of patients, and many them become platelet transfusion-dependent. Eltrombopag thrombopoietin agonist (TPO-RA) able to accelerate megakaryopoiesis, which has been used successfully patients with bone marrow failure immune (ITP). Its role managing other cytopenias CAR-T cell-treated...
ObjectivesTo determine the time to reverse transcription-polymerase chain reaction (RT-PCR) negativity after first positive RT-PCR test, factors associated with longer negativity, proportion of children seroconverting proven severe acute respiratory syndrome coronavirus 2 infection, and lack seroconversion.Study designThe Epidemiological Study Coronavirus in Children Spanish Society Pediatrics is a multicenter study conducted assess characteristics disease 2019. In subset patients, 3 serial...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment for high-risk hematological malignancies in the pediatric population, but relapse remains leading cause of death. We analyzed risk factors associated with relapse.Data from 353 allo-HSCTs 1989 to 2015 our center were studied retrospectively. performed a multivariate analysis pre- and postransplantation variables developed predictive score using significant this training cohort. The results confirmed...
Abstract In this cohort of 42 adolescents with a previous multisystem inflammatory syndrome (MIS-C) diagnosis, 32 (76.2%) were vaccinated COVID-19 vaccines, low incidence relevant adverse events. More importantly, no new MIS-C or myocarditis occurred after median 10 weeks (range 5.3-19.7) post-vaccination.
Hemophagocytic lymphohistiocytosis (HLH) is a condition caused by pathologic immune activation, which responsible for its signs and symptoms. It may also appear as secondary process malignancy. Developing HLH during treatment acute lymphoblastic leukemia (ALL) extremely uncommon, but underdiagnosis be fatal. Two patients with ALL on chemotherapy maintenance who developed triggered infection are presented here. We emphasize the importance of being aware this when patient in complete remission...
Pneumonia is a frequent manifestation of coronavirus disease 2019 (COVID-19) in hospitalized children.The study involved 80 hospitals the severe acute respiratory syndrome 2 (SARS-CoV-2) Spanish Pediatric National Cohort. Participants were children <18 years, with SARS-CoV-2 community-acquired pneumonia (CAP). We compared clinical and radiological characteristics SARS-CoV-2-associated CAP due to other viral etiologies from ValsDance (retrospective) cohort.In total, 151 138 included. Main...