A5018888195- Black Holes and Theoretical Physics
- Cosmology and Gravitation Theories
- Noncommutative and Quantum Gravity Theories
- Relativity and Gravitational Theory
- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- SARS-CoV-2 and COVID-19 Research
- Structural Health Monitoring Techniques
- Animal Virus Infections Studies
- Geophysics and Gravity Measurements
- Viral gastroenteritis research and epidemiology
- Structural Engineering and Vibration Analysis
- Engineering and Information Technology
- Pulsars and Gravitational Waves Research
- Numerical methods in engineering
- Geotechnical Engineering and Analysis
- Advanced Differential Geometry Research
- Geotechnical Engineering and Underground Structures
- Advanced Thermodynamics and Statistical Mechanics
- Advanced Numerical Methods in Computational Mathematics
- Quantum Mechanics and Applications
- Viral Infections and Immunology Research
- Quantum Electrodynamics and Casimir Effect
- Concrete Corrosion and Durability
- Infrastructure Maintenance and Monitoring
Universidad Autónoma de Madrid
2015-2024
Hospital General Universitario Gregorio Marañón
2024
Universidad Nacional Autónoma de México
2024
University of Colorado System
2023
Neurology, Inc
2023
Instituto de Salud Carlos III
2023
Centro de Investigación Biomédica en Red
2023
Instituto de Física Teórica
2022
University of Colorado Denver
2022
Universidad Autónoma Metropolitana
2021
A deletion mutant of severe acute respiratory syndrome coronavirus (SARS-CoV) has been engineered by deleting the structural E gene in an infectious cDNA clone that was constructed as a bacterial artificial chromosome (BAC). The recombinant virus lacking (rSARS-CoV-DeltaE) rescued Vero E6 cells. recovered grew E6, Huh-7, and CaCo-2 cells to titers 20-, 200-, 200-fold lower than wild-type virus, respectively, indicating although protein effect on growth, it is not essential for replication....
The engineering of a full-length infectious cDNA clone and functional replicon the severe acute respiratory syndrome coronavirus (SARS-CoV) Urbani strain as bacterial artificial chromosomes (BACs) is described in this study. In system, viral RNA was expressed cell nucleus under control cytomegalovirus promoter further amplified cytoplasm by replicase. Both were fully stable Escherichia coli. Using SARS-CoV replicon, we have shown that recently RNA-processing enzymes exoribonuclease,...
Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo. To identify factors contribute to rSARS-CoV-ΔE attenuation, expression cells infected by SARS-CoV with or without E was compared. Twenty-five stress response genes were preferentially upregulated during infection absence of gene. In addition, involved signal transduction, transcription, cell metabolism, immunoregulation, inflammation, apoptosis and cycle differentiation...
The phenomenon of "dynamical compactification" in a universe with $4+{n}_{c}$ dimensions is studied, and it found that if the whole process adiabatic, entropy pumped into effective four-dimensional universe. Some cosmological consequences this fact are discussed.
This article presents a general overview of the problems involved in application quantum principle to theory gravitation. The ultraviolet divergences that appear any perturbative computation are reviewed some detail, and it is argued unlikely based on local fields could be consistent. leads natural way supersymmetric extended objects as next candidate study. An elementary introduction superstrings closes review, speculations about most promising avenues research offered.
ABSTRACT The immunogenicity and protective efficacy of a live attenuated vaccine consisting recombinant severe acute respiratory syndrome (SARS) coronavirus lacking the E gene (rSARS-CoV-ΔE) were studied using hamsters. Hamsters immunized with rSARS-CoV-ΔE developed high serum-neutralizing antibody titers protected from replication homologous (SARS-CoV Urbani) heterologous (GD03) SARS-CoV in upper lower tract. rSARS-CoV-ΔE-immunized hamsters remained active following wild-type virus...
The PABP [poly(A)-binding protein] is able to interact with the 3′ poly(A) tail of eukaryotic mRNA, promoting its translation. Cleavage by viral proteases encoded several picornaviruses and caliciviruses plays a role in abrogation cellular protein synthesis. We report that infection MT-2 cells HIV-1 leads efficient proteolysis PABP. Analysis integrity was carried out BHK-21 (baby-hamster kidney) COS-7 upon individual expression protease from members Retroviridae family, e.g. MoMLV (Moloney...
The free energy of the heterotic string is computed in one-loop approximation. Its infrared and ultraviolet behaviors are carefully analyzed, their physical meaning discussed. properties zero-temperature limit explored, as well possibility a phase transition at temperature order Planck mass.
Both $\ensuremath{\beta}$ duality and $R$ in the toroidal compactification of heterotic strings are shown to be symmetries contribution arbitrary genus free energy. This symmetry relates physics at radius coupling $\ensuremath{\kappa}$ with $\frac{{\ensuremath{\alpha}}^{\ensuremath{'}}}{R}$ $\ensuremath{\kappa}{(\frac{{\ensuremath{\alpha}}^{\ensuremath{'}}}{{R}^{2}})}^{\frac{d}{2}}$ where $d$ is number dimensions compactified. Some comments on possible breaking by nonperturbative effects...
The coronavirus nucleocapsid (N) protein is a viral RNA-binding with multiple functions in terms of virus replication and modulating cell signalling pathways. N composed three distinct regions containing motif(s), appropriate signals for signalling. subcellular localization severe acute respiratory syndrome (SARS-CoV) was studied. In infected cells, SARS-CoV localized exclusively to the cytoplasm. contrast avian protein, overexpressed remained principally cytoplasm, very few cells exhibiting...
After entry into animal cells, most viruses hijack essential components involved in gene expression. This is the case of poliovirus, which abrogates cellular translation soon after virus internalization. Abrogation achieved by cleavage both eIF4GI and eIF4GII viral protease 2A. Apart from interference poliovirus with protein synthesis, other expression steps such as RNA trafficking between nucleus cytoplasm are also altered. Poliovirus 2A pro capable hydrolyzing nuclear pore, thus preventing...
The problem of the comological constant appears in a new light Unimodular Gravity. In particular, zero momentum piece potential (that is, independent matter fields) does not automatically produce cosmological proportional to it. aim this paper is give some details on calculation showing that quantum corrections do renormalize classical value observable.