A5028970724- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Virus-based gene therapy research
- COVID-19 and healthcare impacts
- Acute Myeloid Leukemia Research
- Histiocytic Disorders and Treatments
- Respiratory Support and Mechanisms
- Neuroblastoma Research and Treatments
- CRISPR and Genetic Engineering
- Biosimilars and Bioanalytical Methods
- Sepsis Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- RNA Interference and Gene Delivery
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Infectious Disease Case Reports and Treatments
- Adrenal and Paraganglionic Tumors
- Peripheral Nerve Disorders
- Viral-associated cancers and disorders
- Cancer-related cognitive impairment studies
- Sarcoma Diagnosis and Treatment
- Shoulder Injury and Treatment
- Pluripotent Stem Cells Research
Hospital Universitario La Paz
2020-2025
Hospital La Paz Institute for Health Research
2023-2025
Centre for Biomedical Network Research on Rare Diseases
2025
Instituto de Salud Carlos III
2025
Universidad Autónoma de Madrid
2024
Introduction Loss of B-cell aplasia (BCA) is a well-known marker functional loss CD19 CAR-T. Most relapses and BCA occur in the first months after CAR-T infusion. In addition, high tumor burden (HTB) has shown to have strong impact on relapse, especially CD19-negative. However, little known about late or relationship between pre-infusion patients infused with tisagenlecleucel for relapsed/refractory acute lymphoblastic leukemia. Therefore, optimal management yet be defined. Methods We...
Neuroblastoma causes 15% of cancer mortality in children. High risk neuroblastoma has poor prognosis, with high relapse rate and despite multimodal treatment. 123-I-meta-iodo-benzyl-guanidine (mIBG) scintigraphy is one the current standard diagnostic procedures neuroblastoma. mIBG can also be used therapeutically, labeled 131-I, as a radiopharmaceutical agent, delivering targeted radiotherapy to tumoral sites. But published data this strategy show heterogeneous results. One concern that most...
Background: Nerve compression syndromes of the upper extremity are a common cause neuropathic pain and functional impairment. Recently, platelet-rich plasma (PRP) infiltrations have emerged as an effective biological approach to treatment this type injury. The objectives retrospective observational study were assess clinical improvement in patients with median ulnar nerve entrapment syndrome after undergoing biologically-assisted release surgery plasma-rich-in-growth-factors (PRGF)...
Introduction Natural killer (NK) cells are lymphocytes from the innate immune system part of first defense barrier against infected and transformed cells, representing 5%-15% peripheral blood lymphocytes. The cytotoxic capacity NK is controlled by a balance between inhibitory activating receptors expressed on their surface, which recognize interact with ligands stressed cells. cytokines involved in cell activation, proliferation, survival, cytotoxicity signaled mainly through Janus kinase...
Abstract Background Hematopoietic stem cell transplantation (HSCT) is a procedure with high morbidity and mortality. Identifying patients for maximum benefit risk assessment crucial in the decision‐making process. This has led to development of predictive models HSCT adults, which have limitations when applied pediatric population. Our goal was develop an automatic learning algorithm predict survival children malignant disorders undergoing HSCT. Methods We studied allogenic HSCTs performed...
Treatment targeting CD19 by a chimeric antigen receptor expressed on T cells (anti-CD19 CAR-T) has led to breakthrough in the management and treatment of relapsed refractory B- cell acute lymphoblastic leukemia (B-ALL). After infusion, efficacy anti-CD19 CAR-T is monitored bone marrow negative minimal residual disease absence peripheral CD19+ B lymphocytes (B-cell aplasia). In patients who have received an allogenic Hematopoietic Stem Cell Transplantation (HSCT) prior with CAR-T, monitoring...
We report the case of a 7-month-old female patient who developed acute megakaryoblastic leukemia 6 months after appearance skull bone lesions. Initial evaluation and diagnosis this were challenging only achieved thanks to genomic analysis by NGS (next generation sequencing). It is unusual for initial manifestation be lesion. Extramedullary myeloid (eAML), also known as sarcoma (MS), often occurs simultaneously with (AML), although it may precede AML. Genomic based on panel (Oncomine...
La irradiación corporal total (ICT) forma parte del acondicionamiento mieloablativo trasplante de progenitores hematopoyéticos (TPH) en hemopatías malignas. Esta terapia ha demostrado recientemente mayor supervivencia leucemia linfoblástica aguda (LLA) frente a regímenes basados quimioterapia. Sin embargo, los efectos secundarios son una limitación importante, especialmente la población pediátrica. Analizamos retrospectivamente pacientes con LLA que recibieron un TPH hospital terciario entre...
The EPICO-SEHOP platform gathers data from children with SARS-CoV-2 in Spain, allowing comparison between cancer or allogeneic hematopoietic stem cell transplantation (alloHSCT) and those without. infection is milder the cancer/alloHSCT group than without comorbidities (7.1% vs. 15%), except recent alloHSCT (less 300 days), of which 35.7% experienced severe COVID-19. These have been shared SEHOP members to support treatment isolation policies akin for cancer, additional comorbidities. This...
Total body irradiation (TBI) is part of the myeloablative conditioning for hematopoietic stem cell transplantation (HSCT) in malignant hematologic disorders. This therapy has recently shown improved survival acute lymphoblastic leukemia (ALL) compared to chemotherapy-based regimens. However, side effects are a significant limitation, especially pediatric population. We retrospectively analyzed patients with ALL who underwent an HSCT at tertiary hospital between 1996 and 2009 (N = 69 57...
Abstract The EPICO (Spanish general registry of COVID‐19 in children)‐SEHOP Society Pediatric Hematology and Oncology) platform gathers data from children with SARS‐CoV‐2 Spain, allowing comparison between cancer or allogeneic hematopoietic stem cell transplantation (alloHSCT) those without. infection is milder the cancer/alloHSCT group than without comorbidities (7.1% vs. 14.7%), except recent alloHSCT (less 300 days), which 35.7% experienced severe COVID‐19. These have been shared SEHOP...
<title>Abstract</title> Hematological toxicity is the most common long-term adverse event after CAR T-cell therapy. Severe cytopenias not resolving over time may result in life-threatening infection or bleeding and best clinical practice to treat this persisting CAR-T well established. Eleven heavily pretreated patients with B-ALL prolonged cytopenia therapy were successfully treated an allogeneic CD34<sup>+</sup> hematopoietic stem cell (HSC) boost. The median from infusion donor HSC boost...
Objectives This study aimed to evaluate the characteristics and outcomes of infant patients with leukemia. Methods A retrospective analysis was conducted in a cohort 39 diagnosed leukemia from 1990 2020 who underwent treatment at pediatric hemato-oncology department tertiary hospital Madrid, Spain. Results Of 588 cases childhood leukemia, (6.6%) were The 5-year event-free survival overall 43.6% (SE 4.1) 46.5% (SD 24.08), respectively. In univariate analysis, younger age diagnosis associated...
Increasing data on treosulfan-based conditioning regimens before hematopoietic stem cell transplantation (HSCT) demonstrate the consistent benefits of this approach, particularly regarding acute toxicity. This study aimed to describe results in children, focusing toxicity and outcomes when used treat both malignant nonmalignant diseases. retrospective observational pediatric patients treated Spain with HSCT was based collection from electronic clinical records. We studied a total 160 HSCTs...