A5064562730- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- Toxoplasma gondii Research Studies
- Neutropenia and Cancer Infections
- Renal Transplantation Outcomes and Treatments
- Herpesvirus Infections and Treatments
- Neonatal Respiratory Health Research
- Pleural and Pulmonary Diseases
- Transplantation: Methods and Outcomes
- Neuroblastoma Research and Treatments
- Parasitic Infections and Diagnostics
- Cardiac Arrest and Resuscitation
- Insects and Parasite Interactions
- Congenital Diaphragmatic Hernia Studies
- Management of metastatic bone disease
- Cancer therapeutics and mechanisms
- Complement system in diseases
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Vascular Malformations and Hemangiomas
- Spinal Hematomas and Complications
Hospital Infantil Universitario Niño Jesús
2012-2024
Hospital del Niño
2024
Menéndez Pelayo International University
2023
Hospital Universitario HM Madrid
2011
May Institute
2011
Georgetown University Medical Center
1986-1989
Georgetown University
1984-1989
Background Standard treatment for osteosarcoma patients consists of a combination cisplatin, adriamycin, and methotrexate before surgical resection the primary tumour, followed by postoperative chemotherapy including vincristine cyclophosphamide. Unfortunately, many still relapse or suffer adverse events. We examined whether common germline polymorphisms in chemotherapeutic transporter metabolic pathway genes drugs used standard may predict response. Methodology/Principal Findings In this...
Ruxolitinib is a promising treatment for steroid refractory graft-vs-host disease (GvHD). However, data concerning effects on T cells are probably involved in increased risk of opportunistic infections. We analyzed clinical and immunological changes children with GvHD taking ruxolitinib. Twenty-two that underwent transplantation received ruxolitinib were included. indication was acute chronic 13 9 patients, respectively. Overall response rate (ORR) high, 77% 89%, associated an increase CD4...
We retrospectively analyzed outcomes in 67 children with acute leukemia who received hematopoietic stem cell transplantation from alternative allogeneic donors: 29 a haploidentical family donor and 38, an unrelated cord blood donor. All transplantations were performed 1996 through 2010 our center. Neutrophil platelet engraftment significantly delayed after transplantation. The median times to neutrophil recovery 13 d (7–34) 11 (5–70) transplant 20 (9–125) 56 (12–200) (P < 0.001). supportive...
Traditional lung management during extracorporeal membrane oxygenation (ECMO) calls for low inspiratory and expiratory pressures with ventilator rate to achieve rest. However, rapid weaning of severely injured lungs commonly leads marked increase in pulmonary opacification as seen on chest x-ray loss volume. We postulated that a sufficiently high level PEEP could prevent this deterioration. Forty-six newborns, who required ECMO therapy refractory respiratory failure, were maintained 8 14 cm...
We prospectively analyzed outcomes of haploidentical hematopoietic stem cell transplantation using T-cell receptor /CD19+ depleted grafts. Sixty-three transplantations were performed in 60 patients. Twenty-eight patients diagnosed ALL, 27 AML and 8 other hematological malignancies. At time 23 first CR, 20 second beyond CR. Four developed graft failure. Among engrafted patients, the median to neutrophil platelet recovery was 14 (range 9–25) 10 days 7–30), respectively. The probability...
We analyzed the outcome in 22 children with refractory or relapsed non-Hodgkin lymphoma who underwent autologous peripheral blood progenitor cell transplantation between 1994 and 2009. The conditioning regimen used all patients consisted of busulfan cyclophosphamide. Median age was 6 years (range 2 to 16 y). most common histologic subtype Burkitt lymphoma. Ten were complete remission 12 partial at time transplant. median dose CD34+ cells that infused 4.6 × 10/kg 2.1 58.7 10/kg). All...
To evaluate the effectiveness of high-frequency jet ventilation (HFJV) in treatment meconium aspiration, 28 puppies were assigned randomly to one three ventilator techniques. After aspiration 4 ml/kg 20% and baseline measurements on conventional (CV), animals ventilated for 6 h with either CV, HFJV, or HFJV combined slow (combined HFJV). Arterial mixed venous blood gases, systemic pulmonary arterial pressures, capillary wedge pressure, cardiac output measured. Combined proved superior other...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment for high-risk hematological malignancies in the pediatric population, but relapse remains leading cause of death. We analyzed risk factors associated with relapse.Data from 353 allo-HSCTs 1989 to 2015 our center were studied retrospectively. performed a multivariate analysis pre- and postransplantation variables developed predictive score using significant this training cohort. The results confirmed...
The aim of this retrospective study was to analyze the outcome and identify risk factors associated with progression-free survival (PFS) in 36 children high-risk neuroblastoma who underwent autologous peripheral blood progenitor cell (PBPC) transplantation between 1994 2010. conditioning regimen used all cases consisted high-dose busulfan melphalan. Median age at 3 years (range: 0.7-14 years). median times neutrophil platelet engraftment were 11 days 9.16 days) 13 9.33), respectively....
The authors report a case of peritoneal and chest wall metastases in 17-year-old boy previously diagnosed femur osteosarcoma with the lung bones. Although patient achieved complete remission after initial treatment, he presented metastasis 15 months diagnosis. They were resected 3 times received second-line chemotherapy gemcitabine docetaxel. However, 31 diagnosis abdominal masses. In this discuss clinical outcomes how unusual sites are being increasingly reported use new treatments.
We report our results using once-daily intravenous (IV) busulfan (Bu)-based conditioning adjusted by weight without drug monitoring as myeloablative in 47 pediatric patients undergoing first autologous hematopoietic transplantation from 2006 to 2010. Median age was 4 years (range, 1 22 y). There were 35 boys and 12 girls. Conditioning Bu-based all patients. In medulloblastoma (n=12), IV thiotepa at 5 mg/kg/d×2 days associated with Bu. solid tumors other than medulloblastoma, melphalan used...
Abstract Epidural spinal cord compression as the initial presentation of acute lymphoblastic leukemia (ALL) is a rare and serious complication. Extramedullary disease rarely reported in patients with ALL. The most common sites are bone, followed by soft tissue, skin lymph nodes. We describe child B—lineage ALL who presented mass epidural space. She was initially treated intrathecal chemotherapy intravenous dexamethasone total resolution her clinical symptoms but persistent mass. An open...
In the last few decades, survival of children with haematology-oncological malignancies has increased due to more aggressive chemotherapy regimens. This led an increase fungal infections causing significant morbidity and mortality in these patients. Hepatosplenic candidiasis is a disseminated candida infection that affects most commonly liver spleen, although other organs may be involved.We performed retrospective study 13 paediatric patients diagnosed hepatosplenic from January 2002...
T-cell depleted (TCD) haploidentical transplantation using CD3+/CD19+ and TCRαβ+/CD19+ depletion techniques has been increasingly used in children with hematological malignancies. We present a retrospective study aimed to compare transplant outcomes leukemia receiving TCD either or platforms.A total of 159 (ALL=80) (AML=79) that received (n=79) (n=80) platforms between 2005 2020 were included. Median age was 9 years both groups. There no differences patient, donor, characteristics groups...
Abstract Introduction In order to propose risk‐adapted mobilization algorithms, several authors have tried look for predictive factors of the CD34 + yield in healthy pediatric donors. Donor recipient body weight ratio (D/R ratio) was identified as one main variables related with success achieve target cell dose transplantation. According this variable we modified schedule. Material and methods We report results 46 mobilizations apheresis procedures performed our center unfavorable D/R ratio....
Isolated central nervous system (CNS) relapse in acute myeloid leukemia (AML) rarely occurs later than 2 years after remission. We present a child diagnosed with AML (FAB M5) without CNS involvement at diagnosis who was treated chemotherapy and consolidated autologous hematopoietic stem cell transplantation. He complete remission for >6 until he had an isolated relapse. only intrathecal achieved second remission, but relapsed the bone marrow 5 months Treatment of late is discussed.