Irene Rivero‐Calle
A5072981485- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Neonatal Respiratory Health Research
- Bacterial Infections and Vaccines
- Emergency and Acute Care Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Congenital Diaphragmatic Hernia Studies
- COVID-19 Impact on Reproduction
- Hematological disorders and diagnostics
- Pneumocystis jirovecii pneumonia detection and treatment
- Kawasaki Disease and Coronary Complications
- Hepatitis Viruses Studies and Epidemiology
- Tuberculosis Research and Epidemiology
- Orthopedic Infections and Treatments
- Child and Adolescent Health
- Animal Virus Infections Studies
- interferon and immune responses
- Viral Infections and Immunology Research
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2022-2025
Complejo Hospitalario Universitario de Santiago
2016-2025
Instituto de Investigación Sanitaria de Santiago
2016-2025
Universidade de Santiago de Compostela
2015-2025
Servicio Gallego de Salud
2018-2025
Fundación Pública Galega de Medicina Xenómica
2023-2025
Instituto de Salud Carlos III
2022-2024
Efacec (Portugal)
2024
Hospital Universitario La Paz
2023
Universidade da Coruña
2023
After the use of facemasks, other isolation measures enacted during SARS-CoV-2 pandemic were lifted, respiratory pathogens, such as RSV, reappeared, but until November 2023 WHO alert for China,
a b s t r c tRespiratory syncytial virus (RSV) is major cause of respiratory tract infections in adults, particularly older adults and those with underlying medical conditions.Vaccination has emerged as potential key strategy to prevent RSV-related morbidity mortality.This Neumoexperts Prevention (NEP) Group scientific paper aims provide an evidence-based positioning RSV vaccination recommendations for adult patients.We review the current literature on burden vaccine development...
Sepsis is one of the main reasons for non-elective admission to pediatric intensive care units (PICUs), but little known about determinants influencing outcome. We characterized children admitted with community-acquired sepsis European PICUs and studied risk factors mortality disability. Data were collected within collaborative Seventh Framework Programme (FP7)-funded EUCLIDS study, which a prospective multicenter cohort study aiming evaluate genetic susceptibility and/or severity in sepsis....
<sec><title>Background</title> Emerging evidence indicates a potential role for monocytes in COVID-19 immunopathology. We investigated two soluble markers of monocyte activation, sCD14 and sCD163, patients, with the aim characterizing their monocyte-macrophage disease To best our knowledge, this is first study its kind. </sec><sec><title>Methods</title> Fifty-nine SARS-Cov-2 positive hospitalized classified according to ICU or non-ICU admission requirement, were prospectively recruited...
Host genetics is a key determinant of COVID-19 outcomes. Previously, the Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with However, largest impact on outcomes are expected be rare in population. Hence, studying may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome whole-genome sequencing from 21 cohorts across 12 countries performed...
Appropriate treatment and management of children presenting with fever depend on accurate timely diagnosis, but current diagnostic tests lack sensitivity specificity are frequently too slow to inform initial treatment. As an alternative pathogen detection, host gene expression signatures in blood have shown promise discriminating several infectious inflammatory diseases a dichotomous manner. However, differential diagnosis requires simultaneous consideration multiple diseases. Here, we show...
Background Sepsis is defined as dysregulated host response to infection that leads life-threatening organ dysfunction. Biomarkers characterising the in sepsis are lacking. We aimed develop gene expression signatures predict dysfunction children with bacterial or viral infection. Methods This cohort study was done emergency departments and intensive care units of four hospitals Queensland, Australia, recruited aged 1 month 17 years who, upon admission, underwent a diagnostic test, including...
Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality in adults even developed countries. Several lifestyle factors comorbidities have been linked to an increased risk, although their prevalence has not well documented the primary care setting. The aim this study assess incidence, risk factor comorbid conditions distribution CAP Spain.Retrospective observational (>18 years-old) with diagnosed attended at Spain between 2009 2013, using Computerized Database for...
Our aim was to describe the clinical features of mothers with coronavirus disease 2019 (COVID-19) infection during gestation or delivery, and potential vertical transmission. We also wish evaluate possible horizontal transmission after hospital discharge, by means a follow-up all newborns included at 1 month age.This multicenter descriptive study involved 16 Spanish hospitals. reviewed medical records 242 pregnant women diagnosed COVID-19 from March 13 May 31, 2020, when they were in their...
Background Multiple viruses are often detected in children with respiratory infection but the significance of co-infection pathogenesis, severity and outcome is unclear. Objectives To correlate presence viral clinical phenotype admitted acute infections (ARI). Methods We collected detailed information on for ARI as part a Spanish prospective multicenter study (GENDRES network) between 2011–2013. A nested polymerase chain reaction (PCR) approach was used to detect secretions. Findings were...
Monitoring adverse reactions following immunisation is essential, particularly for new vaccines such as those against COVID-19. We describe 20 cases of acute onset a single supraclavicular lymphadenopathy manifesting between 24 h and 9 days after ipsilateral intramuscular administration an mRNA-based COVID-19 vaccine, referred to our WHO Collaborating Centre Vaccine Safety. Our results indicate that the swelling lymph nodes may constitute benign self-limited condition, related higher than...
Background: The limited diagnostic accuracy of biomarkers in children at risk a serious bacterial infection (SBI) might be due to the imperfect reference standard SBI. We aimed evaluate performance new classification algorithm for biomarker discovery Methods: used data from five previously published, prospective observational studies, which included patients aged 0– &lt;16 years: Alder Hey emergency department ( n = 1,120), pediatric intensive care unit 355), Erasmus 1,993), Maasstad...
Coronavirus Disease-19 (COVID-19) symptoms range from mild to severe illness; the cause for this differential response infection remains unknown. Unravelling immune mechanisms acting at different levels of colonization process might be key understand these differences. We carried out a multi-tissue (nasal, buccal and blood; n = 156) gene expression analysis immune-related genes patients affected by COVID-19 severities, healthy controls through nCounter technology. Mild asymptomatic cases...
Abstract Background The morbidity burden of respiratory syncytial virus (RSV) in infants extends beyond hospitalization. Defining the RSV before implementing prophylaxis programs is essential for evaluating any potential impact on short‐ to mid‐term and utilization primary healthcare (PHC) emergency services (ES). We established this reference data using a population‐based cohort approach. Methods Infants hospitalized from January 2016 March 2023 were matched with non‐hospitalized ones based...
Nirsevimab has been recently licensed for universal RSV prophylaxis in infants. NIRSE-GAL is a three-year population-based study initiated Galicia September 2023. It aims to evaluate nirsevimab effectiveness against RSV-related hospitalizations lower respiratory tract infections (LRTI), severe RSV, all-cause LRTI, and hospitalization. also estimate impact on primary healthcare use the short mid-term, children's wheezing asthma, medical prescriptions RSV. The immunization campaigns will be...
Background and Aims A properly validated scoring system allowing objective categorization of infants with acute respiratory infections (ARIs), avoiding the need for in-person assessment that could also be used by non-health professionals is currently not available. We aimed to develop a new clinical scale meeting these specifications. Methods designed (ReSVinet scale) based on seven parameters (feeding intolerance, medical intervention, difficulty, frequency, apnoea, general condition,...
Abstract Infection with SARS-CoV-2 has highly variable clinical manifestations, ranging from asymptomatic infection through to life-threatening disease. Host whole blood transcriptomics can offer unique insights into the biological processes underpinning and disease, as well severity. We performed RNA Sequencing of individuals varying degrees COVID-19 used differential expression analysis pathway enrichment explore how transcriptome differs between mild, moderate, severe COVID-19, performing...